Published in Br J Pharmacol on December 05, 2015
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res (2013) 9.61
Small-conductance, calcium-activated potassium channels from mammalian brain. Science (1996) 5.88
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
Mechanism of calcium gating in small-conductance calcium-activated potassium channels. Nature (1998) 4.94
Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet (2000) 3.87
Choosing the right cell line for breast cancer research. Breast Cancer Res (2011) 3.57
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology (2003) 3.17
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci U S A (2006) 2.85
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Small-conductance Ca2+-activated K+ channels: form and function. Annu Rev Physiol (2011) 2.41
SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala. Nat Neurosci (2005) 2.28
Quantifying Western blots: pitfalls of densitometry. Electrophoresis (2009) 2.25
Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci (2004) 2.08
Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity. J Neurosci (2006) 2.03
Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms. Oncogene (2001) 1.91
Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases. Cancer Res (2013) 1.70
The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors. Br J Pharmacol (2013) 1.70
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev (2012) 1.64
Small conductance Ca2+-activated K+ channels and calmodulin. J Physiol (2003) 1.59
Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: a supporting role to the epidermal growth factor receptor. Endocrinology (2005) 1.53
Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity. Mol Cancer Ther (2008) 1.53
The roles of K(+) channels in cancer. Nat Rev Cancer (2013) 1.46
Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br J Pharmacol (2007) 1.45
Ion channels and transporters in cancer: pathophysiology, regulation, and clinical potential. Cancer Res (2013) 1.45
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J Biol Chem (2001) 1.41
Potassium channels in cell cycle and cell proliferation. Philos Trans R Soc Lond B Biol Sci (2014) 1.29
Small conductance Ca2+-activated K+ channels formed by the expression of rat SK1 and SK2 genes in HEK 293 cells. J Physiol (2003) 1.22
Modulation of SK channel trafficking by beta adrenoceptors enhances excitatory synaptic transmission and plasticity in the amygdala. J Neurosci (2008) 1.22
Cell cycle-related changes in the conducting properties of r-eag K+ channels. J Cell Biol (1998) 1.15
EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK-calmodulin interaction. J Gen Physiol (2009) 1.09
Growth factor signalling and resistance to selective oestrogen receptor modulators and pure anti-oestrogens: the use of anti-growth factor therapies to treat or delay endocrine resistance in breast cancer. Endocr Relat Cancer (2005) 1.09
Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Proc Natl Acad Sci U S A (2006) 1.05
Identification of SK3 channel as a new mediator of breast cancer cell migration. Mol Cancer Ther (2006) 1.04
Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion. Oncogene (2001) 1.03
The SK2-long isoform directs synaptic localization and function of SK2-containing channels. Nat Neurosci (2011) 0.99
UCL 1684: a potent blocker of Ca2+ -activated K+ channels in rat adrenal chromaffin cells in culture. Eur J Pharmacol (1999) 0.96
KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell Death Dis (2011) 0.95
Interactions of ion transporters and channels with cancer cell metabolism and the tumour microenvironment. Philos Trans R Soc Lond B Biol Sci (2014) 0.92
A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts. Am J Physiol Cell Physiol (2009) 0.92
Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein. J Physiol (2006) 0.91
Targeting SKCa channels in cancer: potential new therapeutic approaches. Curr Med Chem (2012) 0.88
Protective Roles for Potassium SK/K(Ca)2 Channels in Microglia and Neurons. Front Pharmacol (2012) 0.86
Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. J Biol Chem (2013) 0.84
Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. Glia (2012) 0.83
Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons. Cell Death Dis (2014) 0.81
Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells. Biochem Biophys Res Commun (2010) 0.80
Calcium-dependent stoichiometries of the KCa2.2 (SK) intracellular domain/calmodulin complex in solution. J Gen Physiol (2014) 0.79
SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2. Neurochem Int (2015) 0.79
Differential regulation of synaptic transmission by pre- and postsynaptic SK channels in the spinal locomotor network. J Neurophysiol (2013) 0.78
Comparison of S-nitrosoglutathione- and staurosporine-induced apoptosis in human neural cells. Can J Physiol Pharmacol (2014) 0.76