Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 26457621)

Published in Environ Res on October 19, 2015

Authors

Shilpa Narayan1, Janet S Sinsheimer2, Kimberly C Paul1, Zeyan Liew1, Myles Cockburn3, Jeff M Bronstein4, Beate Ritz5

Author Affiliations

1: Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
2: Departments of Human Genetics and Biomathematics, David Geffen School of Medicine, and Department of Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.
3: Department of Preventative Medicine, University of Southern California (USC) Keck School of Medicine and Department of Geography, USC, Los Angeles, CA, USA.
4: Department of Neurology, School of Medicine, UCLA, Los Angeles, CA, USA.
5: Department of Epidemiology, Fielding School of Public Health, UCLA, Los Angeles, CA, USA; Department of Neurology, School of Medicine, UCLA, Los Angeles, CA, USA. Electronic address: britz@ucla.edu.

Articles cited by this

A "silent" polymorphism in the MDR1 gene changes substrate specificity. Science (2006) 15.18

Why most discovered true associations are inflated. Epidemiology (2008) 11.22

What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. Neurology (1992) 6.03

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell (1994) 6.02

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci U S A (1989) 4.66

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nat Genet (2014) 4.60

Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California. Am J Epidemiol (2009) 3.02

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin Pharmacol Ther (2004) 2.81

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics (2005) 2.68

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects. Clin Pharmacol Ther (2001) 2.62

Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease. Neurology (2014) 2.24

Clinical characteristics in early Parkinson's disease in a central California population-based study. Mov Disord (2005) 2.19

Historical pesticide exposure in California using pesticide use reports and land-use surveys: an assessment of misclassification error and bias. Environ Health Perspect (2003) 2.03

Pesticides and Parkinson's disease--is there a link? Environ Health Perspect (2006) 2.01

An effective and efficient approach for manually improving geocoded data. Int J Health Geogr (2008) 1.91

Parkinson's disease and brain levels of organochlorine pesticides. Ann Neurol (1994) 1.84

Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Hum Mol Genet (2006) 1.83

Well-water consumption and Parkinson's disease in rural California. Environ Health Perspect (2009) 1.81

Parkinson's disease risk from ambient exposure to pesticides. Eur J Epidemiol (2011) 1.70

Validation of a 26-point telephone version of the Mini-Mental State Examination. J Geriatr Psychiatry Neurol (2004) 1.65

Detection of gene-environment interaction by case-only studies. Jpn J Clin Oncol (1999) 1.53

Organochlorine insecticides in substantia nigra in Parkinson's disease. J Toxicol Environ Health A (2000) 1.48

In situ localization of P-glycoprotein (ABCB1) in human and rat brain. J Histochem Cytochem (2006) 1.25

Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results. Environ Health Perspect (2012) 1.22

Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. Hum Genet (2008) 1.14

Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics (2003) 1.04

MDR1 haplotypes significantly minimize intracellular uptake and transcellular P-gp substrate transport in recombinant LLC-PK1 cells. J Pharm Sci (2006) 1.03

Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease. Pharmacogenetics (2002) 1.02

Job exposure matrix (JEM)-derived estimates of lifetime occupational pesticide exposure and the risk of Parkinson's disease. Arch Environ Occup Health (2014) 1.00

Household organophosphorus pesticide use and Parkinson's disease. Int J Epidemiol (2013) 0.98

Effect of MDR1 haplotype on risk of Parkinson disease. Arch Neurol (2005) 0.95

Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein. Environ Health Perspect (1997) 0.94

MDR1, the blood-brain barrier transporter, is associated with Parkinson's disease in ethnic Chinese. J Med Genet (2004) 0.92

Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1). Pharmacogenetics (2004) 0.91

Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease. Arch Neurol (2010) 0.90

Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure. Environ Int (2013) 0.88

Toward identification of susceptibility genes for sporadic Parkinson's disease. J Neurol (2003) 0.86

Functional evidence for P-glycoprotein at the nose-brain barrier. Pharm Res (2005) 0.85

MDR1 variants and risk of Parkinson disease. Association with pesticide exposure? J Neurol (2009) 0.85

Association of a polymorphism in the ABCB1 gene with Parkinson's disease. Parkinsonism Relat Disord (2009) 0.85

Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in SKP1 in Parkinson׳s disease. Environ Res (2013) 0.85

The ABC of the blood-brain barrier - regulation of drug efflux pumps. Curr Pharm Des (2011) 0.84

Analysis of MDR1 haplotypes in Parkinson's disease in a white population. Neurosci Lett (2004) 0.83

Interaction of insecticides with mammalian P-glycoprotein and their effect on its transport function. Biochim Biophys Acta (2007) 0.83

The association between ambient exposure to organophosphates and Parkinson's disease risk. Occup Environ Med (2014) 0.82

Effects of benzo(e)pyrene and benzo(a)pyrene on P-glycoprotein-mediated transport in Caco-2 cell monolayer: a comparative approach. Toxicol In Vitro (2007) 0.81

Effect of organophosphate pesticide diazinon on expression and activity of intestinal P-glycoprotein. Toxicol Lett (2005) 0.80

Chlorpyrifos alters functional integrity and structure of an in vitro BBB model: co-cultures of bovine endothelial cells and neonatal rat astrocytes. Neurotoxicology (2005) 0.79

Genetic analysis of coding SNPs in blood-brain barrier transporter MDR1 in European Parkinson's disease patients. J Neural Transm (Vienna) (2009) 0.79

MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson's disease: a case-control study in Japan. Drug Metab Pharmacokinet (2012) 0.78

Permeability and toxicological profile estimation of organochlorine compounds by biopartitioning micellar chromatography. Biomed Chromatogr (2009) 0.78