Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.

PubWeight™: 0.75^‹?›

🔗 View Article (PMC 4604200)

Published in PLoS One on October 13, 2015

Authors

Yangchen Dhondup¹, Ivar Sjaastad², Helge Scott³, Øystein Sandanger¹, Lili Zhang², Solveig Bjærum Haugstad², Jan Magnus Aronsen⁴, Trine Ranheim⁵, Sigve Dhondup Holmen⁶, Katrine Alfsnes⁵, Muhammad Shakil Ahmed⁷, Håvard Attramadal⁸, Lars Gullestad⁹, Pål Aukrust¹⁰, Geir Christensen², Arne Yndestad¹¹, Leif Erik Vinge¹²

Author Affiliations

1: Research Institute of Internal medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway.
2: Center for Heart failure Research, University of Oslo, Oslo, Norway; Institute for Experimental Medical Research, Oslo University Hospital, Ullevaal, Oslo, Norway.
3: K.G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway; Department of Pathology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
4: Institute for Experimental Medical Research, Oslo University Hospital, Ullevaal, Oslo, Norway; Bjørknes college, Oslo, Norway.
5: Research Institute of Internal medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway.
6: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital, Ulleval, Oslo, Norway.
7: K.G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway; Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
8: K.G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
9: Center for Heart failure Research, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
10: Research Institute of Internal medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
11: Research Institute of Internal medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammation Research Center, University of Oslo, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
12: Research Institute of Internal medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Center for Heart failure Research, University of Oslo, Oslo, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway.