Published in Arterioscler Thromb Vasc Biol on October 15, 2015
Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. PLoS One (2016) 0.77
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation. Arterioscler Thromb Vasc Biol (2016) 0.77
Intranasal BMP9 Ameliorates Alzheimer Disease-Like Pathology and Cognitive Deficits in APP/PS1 Transgenic Mice. Front Mol Neurosci (2017) 0.75
Activin receptor-like kinases: a diverse family playing an important role in cancer. Am J Cancer Res (2016) 0.75
ALK1 signaling in development and disease: new paradigms. Cell Mol Life Sci (2017) 0.75
Mechanisms of Smooth Muscle Cell Differentiation Are Distinctly Altered in Thoracic Aortic Aneurysms Associated with Bicuspid or Tricuspid Aortic Valves. Front Physiol (2017) 0.75
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature (2007) 9.09
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med (2002) 5.25
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med (2002) 4.69
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61
Chronic DLL4 blockade induces vascular neoplasms. Nature (2010) 3.14
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood (2005) 2.91
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 2.47
Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ Res (2008) 2.43
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development (2003) 2.21
ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway. Dev Cell (2012) 2.14
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature (2012) 2.13
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
Thrombospondins 1 and 2 function as inhibitors of angiogenesis. Matrix Biol (2003) 1.76
Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability. J Biol Chem (2000) 1.68
Molecular basis for the regulation of angiogenesis by thrombospondin-1 and -2. Cold Spring Harb Perspect Med (2012) 1.68
Delta-like 4 induces notch signaling in macrophages: implications for inflammation. Circulation (2007) 1.67
Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia. Am J Pathol (2001) 1.61
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res (2011) 1.55
Thrombospondin-1-deficient mice exhibit increased vascular density during retinal vascular development and are less sensitive to hyperoxia-mediated vessel obliteration. Dev Dyn (2003) 1.53
Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev Cell (2012) 1.53
BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood (2012) 1.53
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol Cancer Ther (2010) 1.38
Thrombospondin-1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor-related protein-1 (LRP-1). J Cell Physiol (2007) 1.35
Laminin-binding integrins induce Dll4 expression and Notch signaling in endothelial cells. Circ Res (2011) 1.30
Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J (2009) 1.29
Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci U S A (2012) 1.26
Enhanced gene activation by Notch and BMP signaling cross-talk. Nucleic Acids Res (2003) 1.20
Endogenous thrombospondin-1 is a cell-surface ligand for regulation of integrin-dependent T-lymphocyte adhesion. Blood (2006) 1.17
Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development (2013) 1.07
Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development. Proc Natl Acad Sci U S A (2013) 1.07
Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell (2013) 1.04
BMP9 regulates endoglin-dependent chemokine responses in endothelial cells. Blood (2012) 1.01
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength. J Exp Med (2013) 1.00
Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch. Nat Commun (2015) 0.99
Therapeutic promise and challenges of targeting DLL4/NOTCH1. Vasc Cell (2011) 0.98
Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells. Blood (2013) 0.96
Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet (2012) 0.94
Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds. J Biol Chem (2010) 0.94
Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence. Development (2013) 0.94
The role of extracellular matrix in vascular branching morphogenesis. Cell Adh Migr (2012) 0.93
Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression. PLoS One (2014) 0.92
Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1. Arterioscler Thromb Vasc Biol (2015) 0.90
Targeting BMP9-promoted human osteosarcoma growth by inactivation of notch signaling. Curr Cancer Drug Targets (2014) 0.89
Molecular pathways: can activin-like kinase pathway inhibition enhance the limited efficacy of VEGF inhibitors? Clin Cancer Res (2014) 0.85
A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis (2015) 0.84
Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis. PLoS One (2012) 0.84
Transforming growth factor-β-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-α1 and redox balance in endothelial cells. Arterioscler Thromb Vasc Biol (2013) 0.84
Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS One (2015) 0.83
Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations. Cardiovasc Res (2015) 0.78
Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway. PLoS One (2014) 0.77
Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model. World J Gastroenterol (2015) 0.76
Pathological Conversion of Mouse Perivascular Adipose Tissue by Notch Activation. Arterioscler Thromb Vasc Biol (2020) 0.75