Published in Evid Based Complement Alternat Med on October 15, 2015
The different expressed serum proteins in rhCygb treated rat model of liver fibrosis by the optimized two-dimensional gel electrophoresis. PLoS One (2017) 0.75
Plumbagin suppresses chronic periodontitis in rats via down-regulation of TNF-α, IL-1β and IL-6 expression. Acta Pharmacol Sin (2017) 0.75
Plumbagin Alleviates Capillarization of Hepatic Sinusoids In Vitro by Downregulating ET-1, VEGF, LN, and Type IV Collagen. Biomed Res Int (2017) 0.75
Mechanisms of hepatic fibrogenesis. Gastroenterology (2008) 11.98
Liver cirrhosis. Lancet (2008) 6.11
Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med (2000) 3.97
Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma. Hepatology (2014) 2.40
Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies. Ann Intern Med (2010) 2.00
Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res (2008) 1.96
Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology (2014) 1.91
Fibrosis-dependent mechanisms of hepatocarcinogenesis. Hepatology (2012) 1.91
EGFR signaling promotes TGFβ-dependent renal fibrosis. J Am Soc Nephrol (2011) 1.64
Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex. Am J Physiol Gastrointest Liver Physiol (2000) 1.58
The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology. Exp Cell Res (2008) 1.53
Proteasome inhibition induces hepatic stellate cell apoptosis. Hepatology (2006) 1.42
A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: comparison with morphometric studies. Hepatology (1994) 1.36
Cirrhosis reversal: a duel between dogma and myth. J Hepatol (2004) 1.34
An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circ Res (2006) 1.30
STAT3 Target Genes Relevant to Human Cancers. Cancers (Basel) (2014) 1.29
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Cell Signal (2013) 1.29
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology (2003) 1.28
Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes. Int Immunopharmacol (2009) 1.24
Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Biochem Biophys Res Commun (2004) 1.22
Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. J Am Soc Nephrol (2012) 1.19
Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol (2010) 1.18
Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia (2008) 1.12
The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. Inflammation (2007) 1.10
Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo. Leuk Res (2009) 1.02
Pathogenesis of liver cirrhosis. World J Gastroenterol (2014) 0.99
Effect of Plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma. Mol Cell Biochem (1993) 0.98
Excess iron modulates endoplasmic reticulum stress-associated pathways in a mouse model of alcohol and high-fat diet-induced liver injury. Lab Invest (2013) 0.96
Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivo. Int J Cancer (2012) 0.95
Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice. Lab Invest (2012) 0.93
Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis. Biochim Biophys Acta (2014) 0.92
Development of a new animal model of liver cirrhosis in swine. Eur Surg Res (2008) 0.89
Inhibitory effect of glycyrrhizin on NF-kappaB binding activity in CCl4- plus ethanol-induced liver cirrhosis in rats. Liver (1998) 0.88
Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-κB signaling pathways. PLoS One (2011) 0.87
Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling. PLoS One (2013) 0.87
Cytotoxicity and apoptosis induced by a plumbagin derivative in estrogen positive MCF-7 breast cancer cells. Anticancer Agents Med Chem (2014) 0.85
Preventive effect of halofuginone on concanavalin A-induced liver fibrosis. PLoS One (2013) 0.84
Plumbagin, a vitamin K3 analogue, abrogates lipopolysaccharide-induced oxidative stress, inflammation and endotoxic shock via NF-κB suppression. Inflammation (2014) 0.83
Effect of losartan on early liver fibrosis development in a rat model of nonalcoholic steatohepatitis. J Gastroenterol Hepatol (2007) 0.83
Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice. Biochem Biophys Res Commun (2013) 0.82
The effect of resveratrol and its methylthio-derivatives on EGFR and Stat3 activation in human HaCaT and A431 cells. Mol Cell Biochem (2014) 0.82
Plumbagin from Plumbago Zeylanica L induces apoptosis in human non-small cell lung cancer cell lines through NF- κB inactivation. Asian Pac J Cancer Prev (2013) 0.82
Expression of heparin-binding epidermal growth factor-like growth factor in the hepatocytes of fibrotic rat liver during hepatocarcinogenesis. J Gastroenterol Hepatol (1999) 0.82
Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-β/Smad interference. J Ethnopharmacol (2014) 0.82
Advanced glycation end-products activate extracellular signal-regulated kinase via the oxidative stress-EGF receptor pathway in renal fibroblasts. J Cell Biochem (2010) 0.81
Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-beta1 gene. Comp Hepatol (2007) 0.80
Treatment of pig serum-induced rat liver fibrosis with Boschniakia rossica, oxymatrine and interferon-alpha. World J Gastroenterol (2005) 0.79
Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis. Dig Dis Sci (2009) 0.79
Plumbagin downregulates Wnt signaling independent of p53 in human colorectal cancer cells. J Nat Prod (2014) 0.79
Heparin-binding epidermal growth factor-like growth factor: a hepatic stellate cell proliferation inducer via ErbB receptors. J Gastroenterol Hepatol (2014) 0.79
Expression of epidermal growth factor receptor and related phosphorylation proteins in hypertrophic scars and normal skin. Chin Med J (Engl) (2002) 0.78
BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor. Int J Clin Exp Pathol (2014) 0.78
Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats. Food Chem (2012) 0.78