Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 4638102)

Published in Mol Brain on November 09, 2015

Authors

Naomi Mamada1,2, Daisuke Tanokashira1, Ai Hosaka1,2, Fuyuki Kametani3, Akira Tamaoka2, Wataru Araki4

Author Affiliations

1: Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, 187-8502, Japan.
2: Department of Neurology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
3: Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, 156-8506, Japan.
4: Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, 187-8502, Japan. araki@ncnp.go.jp.

Articles cited by this

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (1999) 13.19

Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res (1993) 9.81

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch Neurol (2002) 4.42

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron (2007) 3.98

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med (2003) 3.78

The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol (2010) 3.32

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann Neurol (2002) 3.30

Classification and basic pathology of Alzheimer disease. Acta Neuropathol (2009) 3.24

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc Natl Acad Sci U S A (2004) 2.88

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. J Neurosci (2007) 2.49

The eIF2α kinases: their structures and functions. Cell Mol Life Sci (2013) 2.37

Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci (2013) 2.35

GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem (2004) 1.99

Antigen-antibody interaction. Synthetic peptides define linear antigenic determinants recognized by monoclonal antibodies directed to the cytoplasmic carboxyl terminus of rhodopsin. J Biol Chem (1988) 1.82

Two distinct mechanisms target membrane proteins to the axonal surface. Neuron (2003) 1.82

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc Natl Acad Sci U S A (2000) 1.64

Increased beta-secretase activity and expression in rats following transient cerebral ischemia. Brain Res (2004) 1.59

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport (2002) 1.55

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J Neuroinflammation (2009) 1.46

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem (2014) 1.37

Caspase-3 activation as a bifurcation point between plasticity and cell death. Neurosci Bull (2012) 1.32

The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathol (2013) 1.27

Preparing synthetic Aβ in different aggregation states. Methods Mol Biol (2011) 1.26

Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis. J Neurochem (2012) 1.26

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease. Mol Neurodegener (2014) 1.24

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron (2013) 1.21

Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42: involvement of endoplasmic reticulum calcium release in oligomer-induced cell death. Neuroscience (2008) 1.18

Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway. J Biol Chem (2005) 1.14

Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathol (2015) 1.11

Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. PLoS One (2010) 1.11

The increased activity of BACE1 correlates with oxidative stress in Alzheimer's disease. Neurobiol Aging (2007) 1.09

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. FASEB J (2010) 1.06

The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities. Apoptosis (2010) 1.06

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway. Biochim Biophys Acta (2012) 1.05

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease. Neurobiol Aging (2014) 1.00

BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. J Biol Chem (2011) 0.98

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. J Neurosci Res (2010) 0.98

A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production. Cell Rep (2013) 0.96

Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci (2012) 0.95

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. J Neurosci (2015) 0.95

Secretory form of Alzheimer amyloid precursor protein 695 in human brain lacks beta/A4 amyloid immunoreactivity. Biochem Biophys Res Commun (1993) 0.93

Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease. J Biol Chem (2012) 0.92

ER-stress in Alzheimer's disease: turning the scale? Am J Neurodegener Dis (2013) 0.91

Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression. PLoS One (2011) 0.90

Extracellular release of BACE1 holoproteins from human neuronal cells. Biochem Biophys Res Commun (2005) 0.89

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. PLoS One (2014) 0.88

Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons. Cell Rep (2013) 0.86

Therapeutic targeting of the endoplasmic reticulum in Alzheimer's disease. Curr Alzheimer Res (2012) 0.86

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation. Aging Cell (2012) 0.85

Amyloid-β₄₂ activates the expression of BACE1 through the JNK pathway. J Alzheimers Dis (2011) 0.83

Transcriptional and post-transcriptional regulation of β-secretase. IUBMB Life (2012) 0.81

β-amyloid 1-42 induces physiological transcriptional regulation of BACE1. J Neurochem (2012) 0.81

Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant. Brain Behav (2012) 0.80

LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3). eNeuro (2015) 0.78