Published in Curr Med Chem on January 01, 2016
Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J Biol Chem (2002) 2.87
Increased levels of serum S100B protein in critically ill patients without brain injury. Shock (2006) 2.21
Vascular-specific growth factor mRNA levels in the human diaphragm. Respiration (2005) 1.42
Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors. Methods Enzymol (2002) 1.21
Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies. Bioorg Med Chem (2007) 1.12
A structural characterization of human SCO2. Structure (2007) 1.11
Identification of the major constituents of Hypericum perforatum by LC/SPE/NMR and/or LC/MS. Phytochemistry (2006) 1.10
Phenolic compounds and antioxidant activity of olive leaf extracts. Nat Prod Res (2011) 1.05
Structure and organization of drug-target networks: insights from genomic approaches for drug discovery. Mol Biosyst (2009) 1.05
Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs. Bioorg Med Chem (2009) 0.98
LC-UV-solid-phase extraction-NMR-MS combined with a cryogenic flow probe and its application to the identification of compounds present in Greek oregano. Anal Chem (2003) 0.98
Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding. Mol Pharmacol (2009) 0.97
Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res (2009) 0.95
Nature promises new anticancer agents: Interplay with the apoptosis-related BCL2 gene family. Anticancer Agents Med Chem (2014) 0.94
Structural refinement of the hERG1 pore and voltage-sensing domains with ROSETTA-membrane and molecular dynamics simulations. Proteins (2010) 0.92
Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets. Onco Targets Ther (2011) 0.91
Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex. Structure (2012) 0.91
Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases. Eur J Med Chem (2009) 0.90
Novel dehydroepiandrosterone derivatives with antiapoptotic, neuroprotective activity. J Med Chem (2009) 0.89
LC-NMR coupling technology: recent advancements and applications in natural products analysis. Magn Reson Chem (2005) 0.89
Structure and function of the myelin proteins: current status and perspectives in relation to multiple sclerosis. Curr Med Chem (2005) 0.88
Development of accurate binding affinity predictions of novel renin inhibitors through molecular docking studies. J Mol Graph Model (2010) 0.88
Differential effect of Pistacia vera extracts on experimental atherosclerosis in the rabbit animal model: an experimental study. Lipids Health Dis (2010) 0.87
Current concerns and challenges regarding tailored anti-angiogenic therapy in cancer. Expert Rev Anticancer Ther (2009) 0.86
Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata. J Nat Prod (2012) 0.86
AT1 antagonists: a patent review (2008 - 2012). Expert Opin Ther Pat (2013) 0.86
Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem (2012) 0.86
Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry. Angew Chem Int Ed Engl (2014) 0.85
Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity. ACS Chem Biol (2014) 0.85
Antihypertensive drug valsartan in solution and at the AT1 receptor: conformational analysis, dynamic NMR spectroscopy, in silico docking, and molecular dynamics simulations. J Chem Inf Model (2009) 0.84
Binding of novel fullerene inhibitors to HIV-1 protease: insight through molecular dynamics and molecular mechanics Poisson-Boltzmann surface area calculations. J Comput Aided Mol Des (2011) 0.84
Structure-function discrimination of the N- and C- catalytic domains of human angiotensin-converting enzyme: implications for Cl- activation and peptide hydrolysis mechanisms. Protein Eng (2003) 0.84
5alpha,8alpha-Epidioxysterols from the gorgonian Eunicella cavolini and the ascidian Trididemnum inarmatum: isolation and evaluation of their antiproliferative activity. Steroids (2008) 0.84
New concepts, experimental approaches, and dereplication strategies for the discovery of novel phytoestrogens from natural sources. Planta Med (2013) 0.84
The low-dose corticotropin stimulation test in acute traumatic and non-traumatic brain injury: incidence of hypo-responsiveness and relationship to outcome. Intensive Care Med (2004) 0.84
Unprecedented ultra-high-resolution hydroxy group (1)H NMR spectroscopic analysis of plant extracts. J Nat Prod (2011) 0.83
Identification of novel cholesterol-binding regions in Kir2 channels. J Biol Chem (2013) 0.83
Influence of extraction procedures on phenolic content and antioxidant activity of Cretan barberry herb. Food Chem (2012) 0.83
Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis. Eur J Nutr (2013) 0.83
Microsatellite DNA instability in benign lung diseases. Respir Med (2005) 0.83
Structure-oriented UHPLC-LTQ Orbitrap-based approach as a dereplication strategy for the identification of isoflavonoids from Amphimas pterocarpoides crude extract. J Mass Spectrom (2013) 0.82
In silico drug screening approach for the design of magic bullets: a successful example with anti-HIV fullerene derivatized amino acids. J Chem Inf Model (2009) 0.82
Comparison of the solution structures of angiotensin I & II. Implication for structure-function relationship. Eur J Biochem (2003) 0.82
Exploring the "forgotten"-OH NMR spectral region in natural products. Chem Commun (Camb) (2010) 0.82
Comparative biophysical studies of sartan class drug molecules losartan and candesartan (CV-11974) with membrane bilayers. J Phys Chem B (2011) 0.82
The antioxidant effects of a polyphenol-rich grape pomace extract in vitro do not correspond in vivo using exercise as an oxidant stimulus. Oxid Med Cell Longev (2012) 0.81
New insights into the chemical and isotopic composition of human-body biominerals. I: Cholesterol gallstones from England and Greece. J Trace Elem Med Biol (2012) 0.81
Rapid and novel discrimination and quantification of oleanolic and ursolic acids in complex plant extracts using two-dimensional nuclear magnetic resonance spectroscopy-Comparison with HPLC methods. Anal Chim Acta (2009) 0.81
Sesquiterpene lactones from Anthemis melanolepis and their antibacterial and cytotoxic activities. Prediction of their pharmacokinetic profile. J Nat Prod (2010) 0.81
On the molecular basis of the recognition of angiotensin II (AII). NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131. Eur J Biochem (2003) 0.81
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers. Eur J Med Chem (2013) 0.81
G protein-coupled receptor signaling to Kir channels in Xenopus oocytes. Curr Pharm Biotechnol (2014) 0.81
NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations. Eur J Biochem (2004) 0.81
One-step isolation of γ-oryzanol from rice bran oil by non-aqueous hydrostatic countercurrent chromatography. J Sep Sci (2011) 0.81
Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II. ACS Chem Biol (2014) 0.80
Contribution of flavonoids to the overall radical scavenging activity of olive (Olea europaea L.) leaf polar extracts. J Agric Food Chem (2010) 0.80
Estrogenic properties of naturally occurring prenylated isoflavones in U2OS human osteosarcoma cells: Structure-activity relationships. J Steroid Biochem Mol Biol (2010) 0.80
Endocrine abnormalities in critical care patients with moderate-to-severe head trauma: incidence, pattern and predisposing factors. Intensive Care Med (2004) 0.80
New drug delivery nanosystem combining liposomal and dendrimeric technology (liposomal locked-in dendrimers) for cancer therapy. J Pharm Sci (2010) 0.80
Domain architecture of the DRpp29 protein and its interaction with the RNA subunit of Dictyostelium discoideum RNase P. Biochemistry (2010) 0.80
Mapping structural determinants within third intracellular loop that direct signaling specificity of type 1 corticotropin-releasing hormone receptor. J Biol Chem (2012) 0.80
Comparison of different tandem mass spectrometric techniques (ESI-IT, ESI- and IP-MALDI-QRTOF and vMALDI-TOF/RTOF) for the analysis of crocins and picrocrocin from the stigmas of Crocus sativus L. Rapid Commun Mass Spectrom (2012) 0.80
Sulfonamide-1,2,4-thiadiazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies. Chem Pharm Bull (Tokyo) (2010) 0.80
Authenticity of the traditional cypriot spirit "zivania" on the basis of 1h NMR spectroscopy diagnostic parameters and statistical analysis. J Agric Food Chem (2005) 0.80
14N NMR relaxation times of several protein amino acids in aqueous solution--comparison with 17O NMR data and estimation of the relative hydration numbers in the cationic and zwitterionic forms. J Magn Reson (2003) 0.80
Nanoscale enzyme inhibitors: fullerenes inhibit carbonic anhydrase by occluding the active site entrance. Bioorg Med Chem (2010) 0.80
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor. J Nat Prod (2014) 0.80
Insights into AT1 receptor activation through AngII binding studies. J Chem Inf Model (2013) 0.79
Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: the quantitative and temporal interrogation of chemically induced cell death at the protein level. J Proteome Res (2013) 0.79
On the structural basis of the hypertensive properties of angiotensin II: a solved mystery or a controversial issue? Curr Top Med Chem (2004) 0.79
Phytochemical composition of "mountain tea" from Sideritis clandestina subsp. clandestina and evaluation of its behavioral and oxidant/antioxidant effects on adult mice. Eur J Nutr (2011) 0.79
Constituents from Cistus salvifolius (Cistaceae) activate peroxisome proliferator-activated receptor-γ but not -δ and stimulate glucose uptake by adipocytes. Planta Med (2010) 0.79
Interactions of the dipeptide paralysin beta-Ala-Tyr and the aminoacid Glu with phospholipid bilayers. Biochim Biophys Acta (2007) 0.78
A novel role of peripheral corticotropin-releasing hormone (CRH) on dermal fibroblasts. PLoS One (2011) 0.78
Effects of Millettia macrophylla (Fabaceae) extracts on estrogen target organs of female wistar rat. J Pharmacol Sci (2013) 0.78
The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme. Bioorg Med Chem Lett (2006) 0.78
From olive drupes to olive oil. An HPLC-orbitrap-based qualitative and quantitative exploration of olive key metabolites. Planta Med (2013) 0.78
Olive leaf extracts are a natural source of advanced glycation end product inhibitors. J Med Food (2013) 0.78
Diorganotin complexes of a thiosemicarbazone, synthesis: properties, x-ray crystal structure, and antiproliferative activity of diorganotin complexes. Bioinorg Chem Appl (2010) 0.78
Synthetic methodologies in organic chemistry involving incorporation of [¹⁷O] and [¹⁸O] isotopes. J Labelled Comp Radiopharm (2014) 0.77
Rational drug design and synthesis of molecules targeting the angiotensin II type 1 and type 2 receptors. Molecules (2015) 0.77
Domain-selective ligand-binding modes and atomic level pharmacophore refinement in angiotensin I converting enzyme (ACE) inhibitors. Chembiochem (2005) 0.77
Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor. Mol Pharmacol (2010) 0.77
The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives. Eur J Med Chem (2012) 0.77
Comparative study of the AT₁ receptor prodrug antagonist candesartan cilexetil with other sartans on the interactions with membrane bilayers. Biochim Biophys Acta (2012) 0.77
Zinc binding in peptide models of angiotensin-I converting enzyme active sites studied through 1H-NMR and chemical shift perturbation mapping. Biopolymers (2003) 0.77
Investigation of IL-18 and IL-12 in induced sputum of patients with IPF before and after treatment with interferon gamma-1b. Sarcoidosis Vasc Diffuse Lung Dis (2005) 0.77
Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp Hematol (2006) 0.77
Dynamic changes in composition of extracts of natural products as monitored by in situ NMR. Magn Reson Chem (2014) 0.77