Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors.

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🔗 View Article (PMID 26604681)

Published in Biologics on November 06, 2015

Authors

Leslie A Fecher1, William H Sharfman2

Author Affiliations

1: Department of Internal Medicine and Dermatology, Indiana University Health Simon Cancer Center, Indianapolis, IN, USA ; Department of Internal Medicine and Dermatology, University of Michigan, MI, USA.
2: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

Associated clinical trials:

A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449) in Operable Basal Cell Carcinoma | NCT01201915

STEVIE: A Study of Vismodegib in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma | NCT01367665

Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas (Vismodegib) | NCT01556009

Vismodegib for Treatment of Basal Cell Carcinoma (Erivedge) | NCT01543581

Vismodegib in Treating Patients With Basal Cell Carcinoma | NCT01631331

Topical Vitamin D3, Diclofenac or a Combination of Both to Treat Basal Cell Carcinoma | NCT01358045

A Study of Vismodegib With Surgery in Patients With Previously Untreated Basal Cell Carcinoma | NCT01898598

A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas | NCT01815840

Arsenic Trioxide in Treating Patients With Basal Cell Carcinoma (ATO) | NCT01791894

Topical Itraconazole in the Treatment of Basal Cell Carcinoma | NCT02120677

Vismodegib in Basal Cell Carcinomas (BCC) Chemoprevention | NCT02067104

Study Evaluating the Efficacy of Oral Vismodegib in Various Histologic Subtypes | NCT01700049

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