Published in Oncotarget on January 05, 2016
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state. Aging (Albany NY) (2016) 0.75
Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models. Oncotarget (2017) 0.75
Friends-Enemies: Endogenous Retroviruses Are Major Transcriptional Regulators of Human DNA. Front Chem (2017) 0.75
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
Ontological analysis of gene expression data: current tools, limitations, and open problems. Bioinformatics (2005) 22.22
Discovering statistically significant pathways in expression profiling studies. Proc Natl Acad Sci U S A (2005) 8.75
Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77
Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol (2012) 6.38
Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer (2004) 4.70
A review of human carcinogens--part D: radiation. Lancet Oncol (2009) 4.22
Cancer cell metabolism: one hallmark, many faces. Cancer Discov (2012) 3.03
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol (2003) 2.96
Estimating the human mutation rate using autozygosity in a founder population. Nat Genet (2012) 2.44
Early detection and treatment of skin cancer. Am Fam Physician (2000) 2.03
Merging two gene-expression studies via cross-platform normalization. Bioinformatics (2008) 1.93
Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc Natl Acad Sci U S A (2004) 1.87
Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma. Mol Cell (2010) 1.86
Arginine deprivation as a targeted therapy for cancer. Curr Pharm Des (2008) 1.82
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun (2008) 1.55
Methods and approaches in the topology-based analysis of biological pathways. Front Physiol (2013) 1.48
Differential variability analysis of gene expression and its application to human diseases. Bioinformatics (2008) 1.46
Identifying tightly regulated and variably expressed networks by Differential Rank Conservation (DIRAC). PLoS Comput Biol (2010) 1.38
Analysis of the genome to personalize therapy for melanoma. Oncogene (2010) 1.33
The biphasic nature of nitric oxide responses in tumor biology. Antioxid Redox Signal (2006) 1.32
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene (2011) 1.30
Oncofinder, a new method for the analysis of intracellular signaling pathway activation using transcriptomic data. Front Genet (2014) 1.22
Interaction between polyamines and nucleic acids or phospholipids. Arch Biochem Biophys (1982) 1.20
Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells. Aging (Albany NY) (2015) 1.08
The genetics of hereditary melanoma and nevi. 1998 update. Cancer (1999) 1.07
Signaling pathways activation profiles make better markers of cancer than expression of individual genes. Oncotarget (2014) 1.05
Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling. Leukemia (2014) 1.04
Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions. Aging (Albany NY) (2014) 1.04
UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan. Chem Biol Interact (1999) 1.04
The OncoFinder algorithm for minimizing the errors introduced by the high-throughput methods of transcriptome analysis. Front Mol Biosci (2014) 1.04
Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice. Mol Carcinog (2006) 1.04
Novel robust biomarkers for human bladder cancer based on activation of intracellular signaling pathways. Oncotarget (2014) 1.00
Tumor progression, early diagnosis and prognosis of melanoma. Acta Oncol (1999) 0.97
Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis. Clin Cancer Res (2007) 0.96
Learning dysregulated pathways in cancers from differential variability analysis. Cancer Inform (2014) 0.94
Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma. PLoS One (2011) 0.94
Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation. Pigment Cell Melanoma Res (2014) 0.94
Polyamines and nonmelanoma skin cancer. Toxicol Appl Pharmacol (2006) 0.92
Interactome analysis of myeloid-derived suppressor cells in murine models of colon and breast cancer. Oncotarget (2014) 0.91
Pro-survival role of MITF in melanoma. J Invest Dermatol (2014) 0.91
Cyclic AMP (cAMP) signaling in melanocytes and melanoma. Arch Biochem Biophys (2014) 0.89
Update on genetic events in the pathogenesis of melanoma. Curr Opin Oncol (2001) 0.88
Molecular drivers of cellular metabolic reprogramming in melanoma. Trends Mol Med (2015) 0.84
Functional analysis of TMLH variants and definition of domains required for catalytic activity and mitochondrial targeting. J Cell Physiol (2005) 0.84
Clinical Development of Immune Checkpoint Inhibitors. Biomed Res Int (2015) 0.82
A comprehensive view of polyamine and histamine metabolism to the light of new technologies. J Cell Mol Med (2005) 0.80
Submitochondrial localization of 6-N-trimethyllysine dioxygenase - implications for carnitine biosynthesis. FEBS J (2007) 0.78
A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors. Protein Sci (2015) 0.77
Combinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs. Oncotarget (2015) 0.82
A method for predicting target drug efficiency in cancer based on the analysis of signaling pathway activation. Oncotarget (2015) 0.82