Safety, Feasibility, and Efficacy of Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Ischemic Stroke.

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Published in Stroke on December 08, 2015

Authors

Jesse Dawson1, David Pierce2, Anand Dixit2, Teresa J Kimberley2, Michele Robertson2, Brent Tarver2, Omar Hilmi2, John McLean2, Kirsten Forbes2, Michael P Kilgard2, Robert L Rennaker2, Steven C Cramer2, Matthew Walters2, Navzer Engineer2

Author Affiliations

1: From the Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (J.D., M.W.) and Robertson Centre for Biostatistics (M.R.), University of Glasgow, Western Infirmary, Glasgow, United Kingdom; MicroTransponder, Inc., Austin, TX (D.P.); University of Texas at Dallas, Richardson (D.P., B.T., N.E.); Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom (A.D.); Programs in Physical Therapy and Rehabilitation Science, Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis (T.J.K.); Department of Otolaryngology, Glasgow Royal Infirmary (O.H.) and Neuroradiology, Institute of Neurological Sciences, NHS (J.M., K.F.), Greater Glasgow and Clyde, Glasgow, United Kingdom; School of Behavioral and Brain Sciences (M.P.K., R.L.R.) and Department of Bioengineering, Erik Jonsson School of Engineering and Computer Science (M.P.K.), University of Texas at Dallas, Richardson; and the Sue & Bill Gross Stem Cell Research Center, and Departments of Neurology, Anatomy & Neurobiology, and Physical Medicine & Rehabilitation, University of California, Irvine (S.C.C.). jesse.dawson@glasgow.ac.uk.
2: From the Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences (J.D., M.W.) and Robertson Centre for Biostatistics (M.R.), University of Glasgow, Western Infirmary, Glasgow, United Kingdom; MicroTransponder, Inc., Austin, TX (D.P.); University of Texas at Dallas, Richardson (D.P., B.T., N.E.); Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom (A.D.); Programs in Physical Therapy and Rehabilitation Science, Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis (T.J.K.); Department of Otolaryngology, Glasgow Royal Infirmary (O.H.) and Neuroradiology, Institute of Neurological Sciences, NHS (J.M., K.F.), Greater Glasgow and Clyde, Glasgow, United Kingdom; School of Behavioral and Brain Sciences (M.P.K., R.L.R.) and Department of Bioengineering, Erik Jonsson School of Engineering and Computer Science (M.P.K.), University of Texas at Dallas, Richardson; and the Sue & Bill Gross Stem Cell Research Center, and Departments of Neurology, Anatomy & Neurobiology, and Physical Medicine & Rehabilitation, University of California, Irvine (S.C.C.).

Associated clinical trials:

Paired Vagus Nerve Stimulation (VNS) With Rehabilitation for Upper Limb Function Improvement After Stroke | NCT01669161

Pivotal Study of VNS During Rehab After Stroke (VNS-REHAB) (VNS-REHAB) | NCT03131960

Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Arm Function After Stroke (tVNS) | NCT03592745

VNS-induced Corticospinal Plasticity | NCT04088565

VNS-supplemented Motor Retraining After Stroke | NCT04088578

Wireless Nerve Stimulation Device To Enhance Recovery After Stroke | NCT04534556

Combining PAS to Non-invasive VNS | NCT04938284

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