Phase II/III weekly nab-paclitaxel plus gemcitabine or carboplatin versus gemcitabine/carboplatin as first-line treatment of patients with metastatic triple-negative breast cancer (the tnAcity study): study protocol for a randomized controlled trial.

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Published in Trials on December 16, 2015

Authors

Denise A Yardley1, Adam Brufsky2, Robert E Coleman3, Pierfranco F Conte4, Javier Cortes5, Stefan Glück6, Jean-Mark A Nabholtz7, Joyce O'Shaughnessy8, Robert M Beck9, Amy Ko10, Markus F Renschler11, Debora Barton12, Nadia Harbeck13

Author Affiliations

1: Sarah Cannon Research Institute and the Tennessee Oncology, PLLC, 250 25th Avenue North, Suite 100, Nashville, TN, 37203, USA. dyardley@tnonc.com.
2: University of Pittsburgh Medical Center, Pittsburgh, PA, USA. brufskyam@upmc.edu.
3: Weston Park Hospital, Sheffield Cancer Research Center, Sheffield, England. r.e.coleman@sheffield.ac.uk.
4: Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, and Istituto Oncologico Veneto IRCCS, Padova, Italy. pierfranco.conte@unipd.it.
5: Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain. jacortes@vhio.net.
6: Celgene Corporation, Summit, NJ, USA. sgluck@celgene.com.
7: Centre de Lutte Contre le Cancer d'Auvergne, Clermont Ferrand, France. Jean-Marc.NABHOLTZ@cjp.fr.
8: Texas Oncology-Baylor Charles A. Sammons Center; US Oncology, Dallas, TX, USA. Joyce.OShaughnessy@USONCOLOGY.COM.
9: Celgene Corporation, Summit, NJ, USA. rbeck@celgene.com.
10: Celgene Corporation, Summit, NJ, USA. ako@celgene.com.
11: Celgene Corporation, Summit, NJ, USA.
12: Celgene Corporation, Summit, NJ, USA. dbarton@celgene.com.
13: Breast Center, University of Munich, Munich, Germany. Nadia.Harbeck@med.uni-muenchen.de.

Associated clinical trials:

Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer) (tnAcity) | NCT01881230

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