A novel PAD4/SOX4/PU.1 signaling pathway is involved in the committed differentiation of acute promyelocytic leukemia cells into granulocytic cells.

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science (1994) 7.60

Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46

Histone deimination antagonizes arginine methylation. Cell (2004) 5.19

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood (2001) 3.07

Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry (2006) 2.92

High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood (2008) 2.86

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation. Nat Med (2008) 2.85

Regulation of p53 target gene expression by peptidylarginine deiminase 4. Mol Cell Biol (2008) 2.27

Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J Biol Chem (2008) 1.93

Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1alpha,25-dihydroxyvitamin D(3). J Biol Chem (1999) 1.93

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J (1998) 1.84

Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature (2014) 1.81

Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors. Mol Carcinog (2006) 1.70

HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood (2004) 1.52

Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells. Apoptosis (2006) 1.36

Curing APL through PML/RARA degradation by As2O3. Trends Mol Med (2011) 1.27

Regulation of histone modification and chromatin structure by the p53-PADI4 pathway. Nat Commun (2012) 1.20

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2013) 1.17

BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget (2015) 1.12

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. Biochem Pharmacol (2013) 1.05

Clonal remissions in acute nonlymphocytic leukemia: evidence for a multistep pathogenesis of the malignancy. Blood (1991) 1.03

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia. Blood (2013) 0.99

PU.1 is regulated by NF-kappaB through a novel binding site in a 17 kb upstream enhancer element. Oncogene (2009) 0.99

Stat3 promotes the development of erythroleukemia by inducing Pu.1 expression and inhibiting erythroid differentiation. Oncogene (2009) 0.97

C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis. Proc Natl Acad Sci U S A (2014) 0.95

Expression of peptidylarginine deiminase type 4 in ovarian tumors. Int J Biol Sci (2010) 0.94

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia. Blood (2011) 0.92

Overexpression of Wilms tumor 1 gene as a negative prognostic indicator in acute myeloid leukemia. PLoS One (2014) 0.92

Dual regulation of SPI1/PU.1 transcription factor by heat shock factor 1 (HSF1) during macrophage differentiation of monocytes. Leukemia (2014) 0.88

HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia. J Clin Invest (2014) 0.88

PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun (2013) 0.87

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood (2014) 0.87

C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia. Oncotarget (2015) 0.87

TIS21/BTG2/PC3 enhances downregulation of c-Myc during differentiation of HL-60 cells by activating Erk1/2 and inhibiting Akt in response to all-trans-retinoic acid. Eur J Cancer (2012) 0.86

PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation. Nat Commun (2014) 0.85

Epigenetics in acute promyelocytic leukaemia pathogenesis and treatment response: a TRAnsition to targeted therapies. Br J Cancer (2014) 0.82

Krüppel like factor 4 promoter undergoes active demethylation during monocyte/macrophage differentiation. PLoS One (2014) 0.82

Over-expression of Mcl-1 impairs the ability of ATRA to induce growth arrest and differentiation in acute promyelocytic leukemia cells. Apoptosis (2013) 0.81

The limited contribution of DNA methylation to PML-RARα induced leukemia. Oncotarget (2013) 0.78

PADI4 haplotypes in association with RA Mexican patients, a new prospect for antigen modulation. Clin Dev Immunol (2013) 0.76