Published in Sci Rep on December 18, 2015
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (1998) 39.86
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature (2001) 13.76
Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature (1993) 8.20
Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature (1994) 6.45
Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature (2001) 5.45
Ohmic conductance through the inwardly rectifying K channel and blocking by internal Mg2+. Nature (1987) 5.44
Inward rectification of a potassium channel in cardiac ventricular cells depends on internal magnesium ions. Proc Natl Acad Sci U S A (1987) 5.12
Spermine and spermidine as gating molecules for inward rectifier K+ channels. Science (1994) 4.82
Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel. Neuron (1995) 3.70
Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science (2009) 3.48
Voltage-dependent magnesium block of adenosine-triphosphate-sensitive potassium channel in guinea-pig ventricular cells. J Physiol (1987) 3.29
Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell (1998) 3.22
The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J Mol Biol (2003) 3.08
Number of water molecules coupled to the transport of sodium, potassium and hydrogen ions via gramicidin, nonactin or valinomycin. Biochim Biophys Acta (1978) 2.99
Gating of inwardly rectifying K+ channels localized to a single negatively charged residue. Nature (1994) 2.91
Interaction of ions and water in gramicidin A channels: streaming potentials across lipid bilayer membranes. J Gen Physiol (1978) 2.73
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1. J Physiol (1994) 2.55
Ionic basis of the different action potential configurations of single guinea-pig atrial and ventricular myocytes. J Physiol (1985) 2.07
Control of rectification and permeation by two distinct sites after the second transmembrane region in Kir2.1 K+ channel. J Physiol (2001) 2.05
Fast inward-rectifying current accounts for anomalous rectification in olfactory cortex neurones. J Physiol (1983) 2.00
A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification. Proc Natl Acad Sci U S A (2003) 1.99
A structural determinant of differential sensitivity of cloned inward rectifier K+ channels to intracellular spermine. FEBS Lett (1994) 1.94
Electrostatic tuning of ion conductance in potassium channels. Biochemistry (2003) 1.93
Unique Kir2.x properties determine regional and species differences in the cardiac inward rectifier K+ current. Circ Res (2004) 1.70
Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels. J Neurosci (2005) 1.67
Electrostatics of the intracellular vestibule of K+ channels. J Mol Biol (2005) 1.48
A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. J Mol Biol (2004) 1.46
Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel. Proc Natl Acad Sci U S A (1999) 1.26
Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1. J Gen Physiol (1999) 1.22
The polyamine binding site in inward rectifier K+ channels. J Gen Physiol (2006) 1.22
Kinetics of inward-rectifier K+ channel block by quaternary alkylammonium ions. dimension and properties of the inner pore. J Gen Physiol (2001) 1.21
Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1. J Gen Physiol (2006) 1.20
Coupled K+-water flux through the HERG potassium channel measured by an osmotic pulse method. J Gen Physiol (2005) 1.10
Temperature dependence of proton permeation through a voltage-gated proton channel. J Gen Physiol (2009) 1.05
The effects of spermine on the accessibility of residues in the M2 segment of Kir2.1 channels expressed in Xenopus oocytes. J Physiol (2003) 0.99
Mechanism of inward rectification in Kir channels. J Gen Physiol (2004) 0.94
Channel function reconstitution and re-animation: a single-channel strategy in the postcrystal age. J Physiol (2015) 0.92
Counting ion and water molecules in a streaming file through the open-filter structure of the K channel. J Neurosci (2011) 0.92
A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation. Biophys J (2004) 0.90
Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1. J Gen Physiol (2010) 0.84
Cycle flux algebra for ion and water flux through the KcsA channel single-file pore links microscopic trajectories and macroscopic observables. PLoS One (2011) 0.84
A mesoscopic approach to understanding the mechanisms underlying the ion permeation on the discrete-state diagram. J Gen Physiol (2010) 0.83
Electrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels. J Gen Physiol (2005) 0.82
The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel. Pflugers Arch (2013) 0.80
Charges in the cytoplasmic pore control intrinsic inward rectification and single-channel properties in Kir1.1 and Kir2.1 channels. J Membr Biol (2007) 0.79