Published in Biophys J on December 15, 2015
Experimentally Increasing the Compliance of Titin Through RNA Binding Motif-20 (RBM20) Inhibition Improves Diastolic Function In a Mouse Model of Heart Failure With Preserved Ejection Fraction. Circulation (2016) 0.96
Two Kinases to Soften the Heart. Biophys J (2016) 0.75
Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes. Biophys Rev (2017) 0.75
Entropic elasticity of lambda-phage DNA. Science (1994) 15.40
The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line. J Cell Biol (1988) 3.86
Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments. Biophys J (1995) 3.71
The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res (2001) 3.68
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J (2010) 3.62
Control of cardiac growth by histone acetylation/deacetylation. Circ Res (2006) 3.25
Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs. Circ Res (2008) 2.73
CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65
Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity. Circ Res (2000) 2.39
Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res (2002) 2.35
Regulation of skeletal muscle stiffness and elasticity by titin isoforms: a test of the segmental extension model of resting tension. Proc Natl Acad Sci U S A (1991) 2.31
Differential expression of cardiac titin isoforms and modulation of cellular stiffness. Circ Res (2000) 2.28
Atomic force microscopy captures length phenotypes in single proteins. Proc Natl Acad Sci U S A (1999) 2.28
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest (2008) 2.19
Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes. Circ Res (2002) 2.07
Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titin. Circulation (2015) 1.96
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res (2009) 1.91
Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction. Circulation (2013) 1.83
Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. J Cell Sci (2002) 1.77
Titin/connectin and nebulin: giant protein rulers of muscle structure and function. Adv Biophys (1996) 1.76
Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring. Circ Res (1999) 1.75
Fluctuations and supercoiling of DNA. Science (1994) 1.71
Passive and active tension in single cardiac myofibrils. Biophys J (1994) 1.70
Phosphorylation of purified cardiac muscle C-protein by purified cAMP-dependent and endogenous Ca2+-calmodulin-dependent protein kinases. J Biol Chem (1984) 1.67
Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J Biol Chem (2002) 1.61
Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner. J Gen Physiol (2005) 1.61
Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload. Circulation (2004) 1.59
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med (2008) 1.56
The role of calmodulin kinase II in myocardial physiology and disease. Physiology (Bethesda) (2008) 1.52
Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodeling. J Mol Cell Cardiol (2014) 1.48
Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. J Biol Chem (2000) 1.44
Molecular dissection of N2B cardiac titin's extensibility. Biophys J (1999) 1.39
Extensibility of isoforms of cardiac titin: variation in contour length of molecular subsegments provides a basis for cellular passive stiffness diversity. Biophys J (2000) 1.35
Calmodulin kinase is a molecular switch for cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A (2001) 1.34
The mechanically active domain of titin in cardiac muscle. Circ Res (1995) 1.34
Gigantic business: titin properties and function through thick and thin. Circ Res (2014) 1.33
Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease. J Mol Cell Cardiol (2009) 1.30
Titin is a major human disease gene. Circulation (2013) 1.29
Mechanical fatigue in repetitively stretched single molecules of titin. Biophys J (2001) 1.28
Titin: physiological function and role in cardiomyopathy and failure. Heart Fail Rev (2005) 1.22
Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. Circ Res (2013) 1.20
Complete unfolding of the titin molecule under external force. J Struct Biol (1998) 1.19
Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function. Proc Natl Acad Sci U S A (2014) 1.18
Retracted Cytoskeletal disrupting agents prevent calmodulin kinase, IQ domain and voltage-dependent facilitation of L-type Ca2+ channels. J Physiol (2002) 1.16
Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle. J Mol Cell Cardiol (2011) 1.15
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. J Biol Chem (2012) 1.12
Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction. Cardiovasc Res (2012) 1.11
Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice. J Mol Cell Cardiol (2010) 1.08
Cardiac titin and heart disease. J Cardiovasc Pharmacol (2014) 1.08
The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements. J Mol Cell Cardiol (2012) 1.06
Phospholamban phosphorylation by CaMKII under pathophysiological conditions. Front Biosci (2008) 0.99
Tuning the molecular giant titin through phosphorylation: role in health and disease. Trends Cardiovasc Med (2013) 0.97
Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle. Biophys J (2011) 0.95
The effects of PKCalpha phosphorylation on the extensibility of titin's PEVK element. J Struct Biol (2010) 0.94
Mechanical properties of cardiac titin's N2B-region by single-molecule atomic force spectroscopy. J Struct Biol (2006) 0.89
CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol (2012) 0.86
Chasing cardiac physiology and pathology down the CaMKII cascade. Am J Physiol Heart Circ Physiol (2015) 0.83
A site phosphorylated in bovine cardiac troponin T by cardiac CaM kinase II. Biochim Biophys Acta (1995) 0.79