Published in J Neuroinflammation on December 18, 2015
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies. Nat Med (2017) 0.76
Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations. Int J Mol Sci (2017) 0.75
Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril. Sci Rep (2016) 0.75
Animal models of α-synucleinopathy for Parkinson disease drug development. Nat Rev Neurosci (2017) 0.75
Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci (2007) 11.11
Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol (2009) 4.88
Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol (1996) 4.54
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease. J Neurosci (2002) 4.38
Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci (2005) 3.93
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J (2005) 3.60
T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity (2007) 3.26
Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res (2002) 2.96
Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem (2010) 2.67
Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. J Neurosci (2004) 2.64
Neuroinflammatory processes in Parkinson's disease. Ann Neurol (2003) 2.10
Autophagy and cytokines. Cytokine (2011) 1.73
Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging (2007) 1.63
Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem (2010) 1.60
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nat Commun (2013) 1.55
Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci (2012) 1.49
The influence of microglia on the pathogenesis of Parkinson's disease. Prog Neurobiol (2009) 1.39
Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease. J Neurochem (2007) 1.35
Controlling the mass action of alpha-synuclein in Parkinson's disease. J Neurochem (2008) 1.34
Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect (2011) 1.30
Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev (2007) 1.24
IL-10 inhibits the starvation induced autophagy in macrophages via class I phosphatidylinositol 3-kinase (PI3K) pathway. Mol Immunol (2010) 1.20
HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3. PLoS One (2010) 1.14
Dopamine promotes formation and secretion of non-fibrillar alpha-synuclein oligomers. Exp Mol Med (2011) 1.12
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein. Exp Mol Med (2013) 1.12
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models. J Neurosci (2014) 1.11
ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo. Mol Ther (2014) 1.08
Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease. Glia (2008) 1.05
Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse. Behav Brain Res (2012) 1.03
Endotoxin induces a delayed loss of TH-IR neurons in substantia nigra and motor behavioral deficits. Neurotoxicology (2008) 1.03
Autophagy in the immune response to tuberculosis: clinical perspectives. Clin Exp Immunol (2011) 1.00
Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal (2012) 0.93
The relation between α-synuclein and microglia in Parkinson's disease: Recent developments. Neuroscience (2015) 0.89
Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice. J Neuroinflammation (2012) 0.88
Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cell Immunol (2001) 0.86
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Rep (2015) 0.85
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. J Neuroinflammation (2015) 0.84
Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Res (2002) 0.84
Quantitative assessment of microglial morphology and density reveals remarkable consistency in the distribution and morphology of cells within the healthy prefrontal cortex of the rat. J Neuroinflammation (2014) 0.82
β1-integrin-dependent migration of microglia in response to neuron-released α-synuclein. Exp Mol Med (2014) 0.82