Published in PLoS One on January 11, 2016
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc (2012) 35.75
Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast (1998) 23.00
Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe. Yeast (1998) 18.47
Elevated recombination rates in transcriptionally active DNA. Cell (1989) 17.42
Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat Biotechnol (2012) 14.01
Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res (2011) 8.57
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature (2007) 7.12
Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev (1998) 6.75
The petite mutation in yeast. Loss of mitochondrial deoxyribonucleic acid during induction of petites with ethidium bromide. J Mol Biol (1970) 6.44
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A (2002) 5.93
Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J Cell Biol (1999) 5.53
Matrix2png: a utility for visualizing matrix data. Bioinformatics (2003) 5.31
Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature (1990) 5.12
Recombination-mediated PCR-directed plasmid construction in vivo in yeast. Nucleic Acids Res (1997) 5.03
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev (1996) 4.92
Prevalence of mitochondrial DNA disease in adults. Ann Neurol (2008) 4.72
A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods (2008) 3.79
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science (2013) 3.41
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 3.19
RTG1 and RTG2: two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell (1993) 3.13
Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. Cell (2005) 3.05
Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell (2009) 3.00
SNF1/AMPK pathways in yeast. Front Biosci (2008) 2.70
Role of vacuolar acidification in protein sorting and zymogen activation: a genetic analysis of the yeast vacuolar proton-translocating ATPase. Mol Cell Biol (1990) 2.69
Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell (2001) 2.55
Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor. EMBO J (2002) 2.41
GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway. EMBO J (1998) 2.37
Analysis of P-body assembly in Saccharomyces cerevisiae. Mol Biol Cell (2007) 2.37
Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase. Genes Dev (1989) 2.36
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal (2010) 2.36
Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci (2009) 2.35
Import of proteins into mitochondria. Yeast cells grown in the presence of carbonyl cyanide m-chlorophenylhydrazone accumulate massive amounts of some mitochondrial precursor polypeptides. J Biol Chem (1982) 2.34
Nutritional control of growth and development in yeast. Genetics (2012) 2.33
Transport of F1-ATPase subunit beta into mitochondria depends on both a membrane potential and nucleoside triphosphates. FEBS Lett (1986) 2.33
Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription. Mol Cell (2002) 2.29
Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. J Cell Biol (2001) 2.28
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature (2014) 2.27
Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted rho degrees cells. J Biol Chem (1998) 2.25
Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett (2000) 2.22
Harnessing cloud computing with Galaxy Cloud. Nat Biotechnol (2011) 2.19
Cloning and sequencing of the nuclear gene MIP1 encoding the catalytic subunit of the yeast mitochondrial DNA polymerase. J Biol Chem (1989) 2.18
The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics (2011) 2.16
Disruption of genes encoding subunits of yeast vacuolar H(+)-ATPase causes conditional lethality. Proc Natl Acad Sci U S A (1990) 2.14
The role of mitochondria in cellular iron-sulfur protein biogenesis and iron metabolism. Biochim Biophys Acta (2012) 2.09
Arginine metabolism in Saccharomyces cerevisiae: subcellular localization of the enzymes. J Bacteriol (1978) 2.07
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell (2015) 2.03
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature (2012) 2.00
Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations. Nat Genet (2011) 1.92
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. Cell (2015) 1.90
Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae. Mol Cell Biol (2001) 1.89
A dynamic interface between vacuoles and mitochondria in yeast. Dev Cell (2014) 1.87
Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria. EMBO J (2005) 1.87
Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem (2003) 1.86
A 'natural' mutation in Saccharomyces cerevisiae strains derived from S288c affects the complex regulatory gene HAP1 (CYP1). Curr Genet (1999) 1.80
Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications. Leukemia (2003) 1.76
Genome-wide consequences of deleting any single gene. Mol Cell (2013) 1.76
Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.74
Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1. Proc Natl Acad Sci U S A (2006) 1.74
Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J (2000) 1.74
The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda) (2014) 1.68
Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes Dev (1998) 1.68
Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae. Genetics (2012) 1.64
The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria. EMBO J (2001) 1.60
A petite positive strain of Kluyveromyces lactis has a 300 kb deletion in the rDNA cluster. Curr Genet (1989) 1.58
A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. J Cell Biol (2013) 1.56
Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J Biol Chem (2000) 1.54
Prohibitin and mitochondrial biology. Trends Endocrinol Metab (2009) 1.54
Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane. J Biol Chem (1999) 1.52
Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Mol Cell (2014) 1.52
Quantitation and origin of the mitochondrial membrane potential in human cells lacking mitochondrial DNA. Eur J Biochem (1999) 1.51
Hsf1p and Msn2/4p cooperate in the expression of Saccharomyces cerevisiae genes HSP26 and HSP104 in a gene- and stress type-dependent manner. Mol Microbiol (2001) 1.47
Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae. Cell Div (2006) 1.45
Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae. J Biol Chem (2005) 1.44
System of centromeric, episomal, and integrative vectors based on drug resistance markers for Saccharomyces cerevisiae. Biotechniques (2006) 1.43
Regulation of mitochondrial protein import by cytosolic kinases. Cell (2011) 1.42
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L. EMBO J (2011) 1.40
The petite mutation in yeasts: 50 years on. Int Rev Cytol (2000) 1.39
Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics (2009) 1.38
Principles and properties of eukaryotic mRNPs. Mol Cell (2014) 1.37
Using substrate-binding variants of the cAMP-dependent protein kinase to identify novel targets and a kinase domain important for substrate interactions in Saccharomyces cerevisiae. Genetics (2006) 1.35
The Ras/cAMP/protein kinase A pathway regulates glucose-dependent assembly of the vacuolar (H+)-ATPase in yeast. J Biol Chem (2008) 1.33
Oxidative phosphorylatiion in yeast. IV. Combination of a nuclear mutation affecting oxidative phosphorylation with cytoplasmic mutation to respiratory deficiency. Biochim Biophys Acta (1968) 1.32
LETHALITY OF THE PETITE MUTATION IN PETITE NEGATIVE YEASTS. Antonie Van Leeuwenhoek (1964) 1.31
Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane. Mol Biol Cell (2000) 1.31
The absence of the mitochondrial ATP synthase delta subunit promotes a slow growth phenotype of rho- yeast cells by a lack of assembly of the catalytic sector F1. Eur J Biochem (1997) 1.30
Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae. Genetics (2004) 1.30
New treatments for mitochondrial disease-no time to drop our standards. Nat Rev Neurol (2013) 1.26
Molecular pathology of MELAS and L-arginine effects. Biochim Biophys Acta (2011) 1.26
Cyclic AMP-dependent protein kinase regulates the subcellular localization of Snf1-Sip1 protein kinase. Mol Cell Biol (2004) 1.23
An artificial transcription activator mimics the genome-wide properties of the yeast Pdr1 transcription factor. EMBO Rep (2001) 1.21
Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6. Proc Natl Acad Sci U S A (2009) 1.20
Sal1p, a calcium-dependent carrier protein that suppresses an essential cellular function associated With the Aac2 isoform of ADP/ATP translocase in Saccharomyces cerevisiae. Genetics (2004) 1.17
A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Mol Biol Cell (2005) 1.17
Role of mtDNA lesions in anthracycline cardiotoxicity. Cardiovasc Toxicol (2007) 1.14
The cAMP-dependent protein kinase signaling pathway is a key regulator of P body foci formation. Mol Cell (2011) 1.14
Reduced cytosolic protein synthesis suppresses mitochondrial degeneration. Nat Cell Biol (2008) 1.13
Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae. PLoS One (2011) 1.13
Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor. Genes Cells (2009) 1.11