Nonparalytic botulinum molecules for the control of pain.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26761389)

Published in Pain on May 01, 2016

Authors

Antonina S Mangione1, Ilona Obara, Maria Maiarú, Sandrine M Geranton, Cristina Tassorelli, Enrico Ferrari, Charlotte Leese, Bazbek Davletov, Stephen P Hunt

Author Affiliations

1: aCell and Developmental Biology, University College London, London, United KingdombLaboratory of Neurophysiology of Integrative Autonomic System, Headache Sci. Ctr., "C. Mondino" Natl. Neurological Inst, Pavia, ItalycSchool of Medicine, Pharmacy and Health., Durham Univ., Stockton-on-Tees, United KingdomdDepartment of Brain and Behavior, University of Pavia, Pavia, ItalyeSchool of Life Science, University of Lincoln, Lincoln, United KingdomfDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

Articles cited by this

The formalin test: an evaluation of the method. Pain (1992) 7.29

Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain (2000) 6.21

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol (2015) 5.57

Neurotoxins affecting neuroexocytosis. Physiol Rev (2000) 5.42

Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature (1987) 4.59

Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial. Neurology (2009) 2.63

Botulinum neurotoxin: a marvel of protein design. Annu Rev Biochem (2010) 2.54

Attacking pain at its source: new perspectives on opioids. Nat Med (2003) 2.53

Botulinum toxin A for prophylactic treatment of migraine and tension headaches in adults: a meta-analysis. JAMA (2012) 2.40

Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors. J Neurosci (2006) 2.32

Nociceptor sensitization in pain pathogenesis. Nat Med (2010) 2.13

Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins. Toxicon (2000) 1.93

Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia. Brain (2001) 1.72

Local translation in primary afferent fibers regulates nociception. PLoS One (2008) 1.70

Epidermal nerve fibers modulate keratinocyte growth via neuropeptide signaling in an innervated skin model. J Invest Dermatol (2013) 1.67

Long-distance retrograde effects of botulinum neurotoxin A. J Neurosci (2008) 1.66

A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states. J Neurosci (2009) 1.58

The structure and mode of action of different botulinum toxins. Eur J Neurol (2006) 1.51

Botulinum toxin type A reduces histamine-induced itch and vasomotor responses in human skin. Br J Dermatol (2009) 1.45

The concept of neurogenic inflammation. BJU Int (2008) 1.41

A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins. Nat Rev Microbiol (2010) 1.39

Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission. J Physiol Paris (2001) 1.36

Behavioral and immunohistochemical evidence for central antinociceptive activity of botulinum toxin A. Neuroscience (2011) 1.29

Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J Biol Chem (2004) 1.23

Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. Traffic (2006) 1.21

Capsaicin-stimulated release of substance P from cultured dorsal root ganglion neurons: involvement of two distinct mechanisms. Biochem Pharmacol (2000) 1.18

Translating nociceptor sensitivity: the role of axonal protein synthesis in nociceptor physiology. Eur J Neurosci (2009) 1.14

Botulinum toxin A and chronic low back pain: a randomized, double-blind study. Neurology (2001) 1.11

Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A). J Neurosci (2011) 1.11

Botulinum toxin A, brain and pain. Prog Neurobiol (2014) 1.05

Subcutaneous Botulinum toxin type A reduces capsaicin-induced trigeminal pain and vasomotor reactions in human skin. Pain (2008) 0.99

SNARE tagging allows stepwise assembly of a multimodular medicinal toxin. Proc Natl Acad Sci U S A (2010) 0.98

Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice. Pain (2011) 0.98

Botulinum Toxin A reduces neurogenic flare but has almost no effect on pain and hyperalgesia in human skin. J Neurol (2003) 0.98

Axonal protein synthesis: a potential target for pain relief? Curr Opin Pharmacol (2011) 0.97

Pathophysiology of postoperative pain. Pain (2011) 0.96

Clostridial neurotoxins: mechanism of SNARE cleavage and outlook on potential substrate specificity reengineering. Toxins (Basel) (2010) 0.95

Botulinum toxin type A reduces capsaicin-evoked pain and neurogenic vasodilatation in human skin. Pain (2006) 0.92

Therapeutic use of botulinum toxin in migraine: mechanisms of action. Br J Pharmacol (2014) 0.88

Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity. Toxins (Basel) (2011) 0.87

Modulation of keratinocyte proliferation by skin innervation. J Invest Dermatol (1999) 0.87

Lack of anti-inflammatory effect of botulinum toxin type A in experimental models of inflammation. Fundam Clin Pharmacol (2008) 0.87

Genome-wide transcriptional profiling of skin and dorsal root ganglia after ultraviolet-B-induced inflammation. PLoS One (2014) 0.86

Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 present. Biochemistry (1997) 0.85

Assembly of protein building blocks using a short synthetic peptide. Bioconjug Chem (2012) 0.85

Influence of cutaneous nerves on keratinocyte proliferation and epidermal thickness in mice. Neuroscience (1999) 0.85

Synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjug Chem (2013) 0.85

Toll like receptor (TLR)-4 as a regulator of peripheral endogenous opioid-mediated analgesia in inflammation. Mol Pain (2014) 0.85

Botulinum toxin type A reduces hyperalgesia and TRPV1 expression in rats with neuropathic pain. Pain Med (2013) 0.84

Botulinum toxin-A treatment reduces human mechanical pain sensitivity and mechanotransduction. Ann Neurol (2014) 0.82

Articles by these authors

Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci (2002) 2.94

Illicit drug use in cluster headache patients and in the general population: a comparative cross-sectional survey. Cephalalgia (2012) 2.48

Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nat Neurosci (2002) 2.24

Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion. Nature (2002) 2.11

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Lett (2006) 2.04

Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. Neuron (2009) 2.03

Aortic biological valve prosthesis in patients younger than 65 years of age: transition to a flexible age limit? Interact Cardiovasc Thorac Surg (2013) 1.92

Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature (2006) 1.86

Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science (2008) 1.77

Local translation in primary afferent fibers regulates nociception. PLoS One (2008) 1.70

Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice. J Invest Dermatol (2007) 1.67

Arachidonic acid allows SNARE complex formation in the presence of Munc18. Chem Biol (2005) 1.65

Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. Hepatology (2006) 1.61

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein. FEBS Lett (2004) 1.60

A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states. J Neurosci (2009) 1.58

Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur J Hum Genet (2006) 1.56

Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain (2005) 1.54

Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells. J Neurochem (2014) 1.49

Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain (2005) 1.49

Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci (2009) 1.47

The transventricular-transseptal access to the aortic root: a new route for extrapleural trans-catheter aortic stent-valve implantation. Eur J Cardiothorac Surg (2011) 1.46

Development and validation of the EUROLIGHT questionnaire to evaluate the burden of primary headache disorders in Europe. Cephalalgia (2010) 1.40

Towards no-scar cardiac surgery - minimally invasive access through umbilicus for aortic valve replacement. Eur J Cardiothorac Surg (2009) 1.40

Therapy of acute massive pulmonary embolism associated with Klippel-Trenaunay syndrome. Ann Vasc Surg (2010) 1.39

A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. J Neurosci (2007) 1.38

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission. Nat Neurosci (2012) 1.30

Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. J Biol Chem (2004) 1.30

Mechanism of calcium-independent synaptotagmin binding to target SNAREs. J Biol Chem (2002) 1.27

Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. Synapse (2009) 1.27

Descending facilitatory control of mechanically evoked responses is enhanced in deep dorsal horn neurones following peripheral nerve injury. Brain Res (2004) 1.26

Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells. Mol Biol Cell (2007) 1.26

Alpha-synuclein, lipids and Parkinson's disease. Prog Lipid Res (2010) 1.24

Properties of the force exerted by filopodia and lamellipodia and the involvement of cytoskeletal components. PLoS One (2007) 1.23

High affinity interaction of syntaxin and SNAP-25 on the plasma membrane is abolished by botulinum toxin E. J Biol Chem (2003) 1.23

Conserved prefusion protein assembly in regulated exocytosis. Mol Biol Cell (2005) 1.20

Relationship between hallucinations, delusions, and rapid eye movement sleep behavior disorder in Parkinson's disease. Mov Disord (2005) 1.20

Action of complexin on SNARE complex. J Biol Chem (2002) 1.19

Influence of deep sternal wound infection on long-term survival after cardiac surgery. Med Sci Monit (2013) 1.19

Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO Rep (2010) 1.17

Depletion of endogenous spinal 5-HT attenuates the behavioural hypersensitivity to mechanical and cooling stimuli induced by spinal nerve ligation. Pain (2006) 1.17

The impact of headache in Europe: principal results of the Eurolight project. J Headache Pain (2014) 1.17

Diagnostic and therapeutic errors in trigeminal autonomic cephalalgias and hemicrania continua: a systematic review. J Headache Pain (2013) 1.16

Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptors. Neuropharmacology (2002) 1.16

Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse. J Neurosci (2003) 1.15

The differential contribution of tumour necrosis factor to thermal and mechanical hyperalgesia during chronic inflammation. Arthritis Res Ther (2005) 1.13

Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury. J Neurosci (2009) 1.13

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system. Arthritis Rheum (2008) 1.12

Italian guidelines for primary headaches: 2012 revised version. J Headache Pain (2012) 1.10

Descending serotonergic controls regulate inflammation-induced mechanical sensitivity and methyl-CpG-binding protein 2 phosphorylation in the rat superficial dorsal horn. Mol Pain (2008) 1.10

Mechanism of arachidonic acid action on syntaxin-Munc18. EMBO Rep (2007) 1.09

Experimental acute pancreatitis in PAP/HIP knock-out mice. Gut (2007) 1.08

Wave front engineering for microscopy of living cells. Opt Express (2005) 1.08

Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses. J Neurochem (2007) 1.07

Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury. Exp Neurol (2004) 1.07

Delayed primary versus late secondary wound closure in the treatment of postsurgical sternum osteomyelitis. Interact Cardiovasc Thorac Surg (2011) 1.07

Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects. Circulation (2012) 1.07

Getting muscles moving again after botulinum toxin: novel therapeutic challenges. Trends Mol Med (2003) 1.05

The murine neurokinin NK1 receptor gene contributes to the adult hypoxic facilitation of ventilation. Eur J Neurosci (2002) 1.05

Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation. Biochemistry (2006) 1.04

Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent. Radiology (2008) 1.04

DOC2B acts as a calcium switch and enhances vesicle fusion. J Neurosci (2008) 1.02

Clinical and neuroinflammatory responses to meningoencephalitis in substance P receptor knockout mice. Brain (2003) 1.02

A molecular basis underlying differences in the toxicity of botulinum serotypes A and E. EMBO Rep (2004) 1.01

Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition. J Mol Med (Berl) (2005) 1.01

Dynamic pattern of reg-2 expression in rat sensory neurons after peripheral nerve injury. J Neurosci (2002) 1.01

The expression of spinal methyl-CpG-binding protein 2, DNA methyltransferases and histone deacetylases is modulated in persistent pain states. Mol Pain (2012) 1.00

Cross-linking of phospholipid membranes is a conserved property of calcium-sensitive synaptotagmins. J Mol Biol (2008) 0.99

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering. J Neurosci (2013) 0.99

Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family. Biochem J (2004) 0.99

Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell. Biochem J (2005) 0.99

Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice. Pain (2011) 0.98

Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity. Trends Neurosci (2004) 0.98

SNARE tagging allows stepwise assembly of a multimodular medicinal toxin. Proc Natl Acad Sci U S A (2010) 0.98

Self-assembly of SNARE fusion proteins into star-shaped oligomers. Biochem J (2005) 0.98

Axonal protein synthesis: a potential target for pain relief? Curr Opin Pharmacol (2011) 0.97

The Headache Under-Response to Treatment (HURT) Questionnaire: assessment of utility in headache specialist care. Cephalalgia (2012) 0.97

Sexual function and distress in women treated for primary headaches in a tertiary university center. J Sex Med (2012) 0.96

Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond. Alcohol (2009) 0.96

Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice. Psychopharmacology (Berl) (2010) 0.96

Botulinum toxin type-A in the prophylactic treatment of medication-overuse headache: a multicenter, double-blind, randomized, placebo-controlled, parallel group study. J Headache Pain (2011) 0.95

Electrophysiological evidence for trigeminal neuron sensitization in patients with migraine. Neurosci Lett (2002) 0.95

Performance deficits of NK1 receptor knockout mice in the 5-choice serial reaction-time task: effects of d-amphetamine, stress and time of day. PLoS One (2011) 0.95

Antagonism of L-type Ca(v) channels with nifedipine differentially affects performance of wildtype and NK1R-/- mice in the 5-Choice Serial Reaction-Time Task. Neuropharmacology (2012) 0.94

Force generation in lamellipodia is a probabilistic process with fast growth and retraction events. Biophys J (2010) 0.94

Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- mice. Eur J Neurosci (2007) 0.93

Absence of Whisker-related pattern formation in mice with NMDA receptors lacking coincidence detection properties and calcium signaling. J Neurosci (2003) 0.93

Oral nitric-oxide donor glyceryl-trinitrate induces sensitization in spinal cord pain processing in migraineurs: a double-blind, placebo-controlled, cross-over study. Eur J Pain (2010) 0.93

Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood (2007) 0.92

Inhibition of inflammation and hyperalgesia in NK-1 receptor knock-out mice. Neuroreport (2003) 0.92

Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus. Eur J Neurosci (2003) 0.92

The effects of local pentoxifylline and propentofylline treatment on formalin-induced pain and tumor necrosis factor-alpha messenger RNA levels in the inflamed tissue of the rat paw. Anesth Analg (2004) 0.91

Temporal profile of vascular changes induced by systemic nitroglycerin in the meningeal and cortical districts. Cephalalgia (2010) 0.91

Identification of novel pharmacological targets to minimize excitotoxic retinal damage. Int Rev Neurobiol (2009) 0.90

A comparison of neurokinin 1 receptor knock-out (NK1-/-) and wildtype mice: exploratory behaviour and extracellular noradrenaline concentration in the cerebral cortex of anaesthetised subjects. Neuropharmacology (2005) 0.90

Focus on therapy: hemicrania continua and new daily persistent headache. J Headache Pain (2010) 0.89