PubRank

Leendert H J Looijenga

Author PubWeight™ 132.10‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006 11.01
2 Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 2004 8.35
3 Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005 7.66
4 A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 2005 6.70
5 Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 2005 3.75
6 Noninvasive detection of testicular carcinoma in situ in semen using OCT3/4. Eur Urol 2007 3.34
7 Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. Genes Chromosomes Cancer 2006 2.50
8 Germ cell tumors in the intersex gonad: old paths, new directions, moving frontiers. Endocr Rev 2006 2.40
9 Role of P53 and MDM2 in treatment response of human germ cell tumors. J Clin Oncol 2002 2.36
10 The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Am J Hum Genet 2005 2.26
11 Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. J Clin Oncol 2009 2.11
12 Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. Oncogene 2002 2.03
13 The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Proc Natl Acad Sci U S A 2009 1.59
14 CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells. Nat Biotechnol 2006 1.58
15 The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer 2005 1.51
16 Testicular microlithiasis in boys and young men with congenital or acquired undescended (ascending) testis. J Urol 2010 1.48
17 Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol 2004 1.47
18 Successful treatment of low-grade oligodendroglial tumors with a chemotherapy regimen of procarbazine, lomustine, and vincristine. Cancer 2005 1.45
19 Lessons from human teratomas to guide development of safe stem cell therapies. Nat Biotechnol 2012 1.43
20 Histopathological and molecular features of late relapses in non-seminomas. BJU Int 2010 1.40
21 Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. Hum Pathol 2005 1.36
22 Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features. Cancer 2003 1.32
23 Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance. Biol Reprod 2009 1.26
24 Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance. J Pathol 2010 1.24
25 Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. Cancer Res 2005 1.23
26 Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives. Int J Androl 2007 1.22
27 Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours. J Pathol 2005 1.22
28 New insights into type II germ cell tumor pathogenesis based on studies of patients with various forms of disorders of sex development (DSD). Mol Cell Endocrinol 2008 1.19
29 Gonadoblastoma arising in undifferentiated gonadal tissue within dysgenetic gonads. J Clin Endocrinol Metab 2006 1.19
30 12p-amplicon structure analysis in testicular germ cell tumors of adolescents and adults by array CGH. Oncogene 2003 1.18
31 Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus. Gut 2012 1.18
32 Stem cell marker OCT3/4 in tumor biology and germ cell tumor diagnostics: history and future. Crit Rev Oncog 2006 1.16
33 A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Adv Exp Med Biol 2007 1.15
34 Further characterization of the first seminoma cell line TCam-2. Genes Chromosomes Cancer 2008 1.09
35 Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC Dev Biol 2008 1.08
36 Morphological and immunohistochemical differences between gonadal maturation delay and early germ cell neoplasia in patients with undervirilization syndromes. J Clin Endocrinol Metab 2005 1.04
37 Molecular markers predict outcome in squamous cell carcinoma of the head and neck after concomitant cisplatin-based chemoradiation. Int J Cancer 2009 1.04
38 Genetic aspects of testicular germ cell tumors. Cell Cycle 2008 1.04
39 Molecular determinants of treatment response in human germ cell tumors. Clin Cancer Res 2003 1.03
40 IGF2/H19 imprinting analysis of human germ cell tumors (GCTs) using the methylation-sensitive single-nucleotide primer extension method reflects the origin of GCTs in different stages of primordial germ cell development. Genes Chromosomes Cancer 2005 1.00
41 Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline. Proc Natl Acad Sci U S A 2013 1.00
42 Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care. Horm Res Paediatr 2016 0.97
43 Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment. Cancer Res 2002 0.97
44 The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors. Hum Pathol 2007 0.97
45 Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle. Mol Oncol 2013 0.96
46 Current views on the pathogenesis of testicular germ cell tumours and perspectives for future research: highlights of the 5th Copenhagen Workshop on Carcinoma in situ and Cancer of the Testis. APMIS 2003 0.95
47 The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression. Genes Chromosomes Cancer 2011 0.95
48 NANOG promoter methylation and expression correlation during normal and malignant human germ cell development. Epigenetics 2011 0.94
49 Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. Development 2012 0.94
50 Characteristics of testicular dysgenesis syndrome and decreased expression of SRY and SOX9 in Frasier syndrome. Mol Reprod Dev 2008 0.93
51 Recent developments in testicular germ cell tumor research. Birth Defects Res C Embryo Today 2009 0.93
52 Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis. J Mol Cell Biol 2010 0.92
53 JKT-1 is not a human seminoma cell line. Int J Androl 2007 0.90
54 Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis. Eur J Endocrinol 2013 0.90
55 DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours. BMC Res Notes 2012 0.90
56 A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation. J Exp Med 2011 0.89
57 Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors. Int J Endocrinol 2012 0.89
58 Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes. Oncogene 2003 0.89
59 VASA is a specific marker for both normal and malignant human germ cells. Lab Invest 2002 0.88
60 New insights into the pathology and molecular biology of human germ cell tumors. World J Urol 2004 0.88
61 Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. Cancer Res 2002 0.88
62 Mutation analysis of the LH receptor gene in Leydig cell adenoma and hyperplasia and functional and biochemical studies of activating mutations of the LH receptor gene. J Clin Endocrinol Metab 2011 0.88
63 Germ cell lineage differentiation in non-seminomatous germ cell tumours. J Pathol 2006 0.87
64 Mutations in LRRC50 predispose zebrafish and humans to seminomas. PLoS Genet 2013 0.87
65 Involvement of E-cadherin and beta-catenin in germ cell tumours and in normal male fetal germ cell development. J Pathol 2004 0.86
66 Comparative proteome, transcriptome, and genome analysis of a gonadal and an extragonadal germ cell tumor cell line. J Proteome Res 2008 0.86
67 Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors. Hum Pathol 2006 0.85
68 Gene expression profiling and gene copy-number changes in malignant mesothelioma cell lines. Genes Chromosomes Cancer 2007 0.85
69 Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1. Neoplasia 2004 0.85
70 A novel SRY missense mutation affecting nuclear import in a 46,XY female patient with bilateral gonadoblastoma. Eur J Hum Genet 2009 0.84
71 Cord blood for tissue regeneration. J Cell Biochem 2009 0.84
72 Value of α-methylacyl-CoA racemase immunochemistry for predicting neoplastic progression in Barrett's oesophagus. Histopathology 2013 0.83
73 Managing the risk of germ cell tumourigenesis in disorders of sex development patients. Endocr Dev 2014 0.83
74 Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer. Int J Dev Biol 2013 0.83
75 Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays. Genomics 2011 0.82
76 Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads. Clin Endocrinol (Oxf) 2007 0.82
77 Role of epigenetics in the etiology of germ cell cancer. Int J Dev Biol 2013 0.81
78 Xeroderma pigmentosum group a protein and chemotherapy resistance in human germ cell tumors. Lab Invest 2003 0.81
79 Disorders of sex development: update on the genetic background, terminology and risk for the development of germ cell tumors. World J Pediatr 2009 0.81
80 Testicular germ cell tumors. Pediatr Endocrinol Rev 2014 0.81
81 Differential methylation of the OCT3/4 upstream region in primary human testicular germ cell tumors. Oncol Rep 2007 0.80
82 Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness. J Pathol 2009 0.80
83 Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas. PLoS One 2012 0.80
84 Diagnosis of testicular carcinoma in situ '(intratubular and microinvasive)' seminoma and embryonal carcinoma using direct enzymatic alkaline phosphatase reactivity on frozen histological sections. Histopathology 2011 0.80
85 Establishment and characterization of a new human extragonadal germ cell line, SEM-1, and its comparison with TCam-2 and JKT-1. Urology 2013 0.79
86 Germ cell tumours in neonates and infants: a distinct subgroup? APMIS 2003 0.78
87 Heterogeneous distribution of ITGCNU in an adult testis: consequences for biopsy-based diagnosis. Int J Surg Pathol 2008 0.78
88 Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Hum Mol Genet 2005 0.78
89 Involvement of the Fas/FasL pathway in the pathogenesis of germ cell tumours of the adult testis. J Pathol 2002 0.78
90 A 46,XY female DSD patient with bilateral gonadoblastoma, a novel SRY missense mutation combined with a WT1 KTS splice-site mutation. PLoS One 2012 0.77
91 P53 and SOX2 Protein Expression Predicts Esophageal Adenocarcinoma in Response to Neoadjuvant Chemoradiotherapy. Ann Surg 2017 0.76
92 Are all testicular seminomas of animals in fact spermatocytic seminomas? Vet Pathol 2007 0.76
93 A pure triphasic testicular wilms tumor of primordial germ cell origin. Urology 2008 0.75
94 Value of cyclin A immunohistochemistry for cancer risk stratification in Barrett esophagus surveillance: A multicenter case-control study. Medicine (Baltimore) 2016 0.75
95 Application of the new classification on patients with a disorder of sex development in indonesia. Int J Endocrinol 2011 0.75
96 VASA mRNA (DDX4) detection is more specific than immunohistochemistry using poly- or monoclonal antibodies for germ cells in the male urogenital tract. Medicine (Baltimore) 2017 0.75
97 Multiparameter Investigation of a 46,XX/46,XY Tetragametic Chimeric Phenotypical Male Patient with Bilateral Scrotal Ovotestes and Ovulatory Activity. Sex Dev 2017 0.75
98 P53 and SOX2 Protein Expression Predicts Esophageal Adenocarcinoma in Response to Neoadjuvant Chemoradiotherapy. Ann Surg 2016 0.75
99 Aberrant SOX2 expression in colorectal cancers does not correlate with mucinous differentiation and gastric mucin MUC5AC expression. Virchows Arch 2014 0.75
100 Histological Assessment of Gonads in DSD: Relevance for Clinical Management. Sex Dev 2017 0.75
101 Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept. Int J Dev Biol 2013 0.75
102 Gonadal malignancy in 13 consecutive collected patients with disorders of sex development (DSD) from Semarang (Indonesia). J Clin Pathol 2012 0.75
103 A Rare Case of Embryonal Carcinoma in a Patient with Turner Syndrome without Y Chromosomal Material but Mutations in KIT, AKT1, and ZNF358 Demonstrated Using Exome Sequencing. Sex Dev 2017 0.75
104 Advances in molecular markers of germ cell cancer in patients with disorders of sex development. Endocr Dev 2014 0.75
105 A 40-year-old woman with a progressive periventricular white matter lesion. Brain Pathol 2008 0.75
106 miMsg: a target enrichment algorithm for predicted miR-mRNA interactions based on relative ranking of matched expression data. Bioinformatics 2013 0.75