Tropomyosin diffusion over actin subunits facilitates thin filament assembly.

PubWeight™: 0.86‹?›

🔗 View Article (PMID 26798831)

Published in Struct Dyn on January 14, 2016

Authors

Stefan Fischer1, Michael J Rynkiewicz2, Jeffrey R Moore3, William Lehman2

Author Affiliations

1: Computational Biochemistry Group, Interdisciplinary Center for Scientific Computing (IWR), University of Heidelberg , Im Neuenheimer Feld 368, D69120 Heidelberg, Germany.
2: Department of Physiology and Biophysics, Boston University School of Medicine , 72 East Concord Street, Boston, Massachusetts 02118, USA.
3: Department of Biological Sciences, University of Massachusetts Lowell , One University Avenue, Lowell, Massachusetts 01854, USA.

Articles cited by this

How do site-specific DNA-binding proteins find their targets? Nucleic Acids Res (2004) 6.17

Structural role of tropomyosin in muscle regulation: analysis of the x-ray diffraction patterns from relaxed and contracting muscles. J Mol Biol (1973) 4.10

The 14-fold periodicity in alpha-tropomyosin and the interaction with actin. J Mol Biol (1976) 3.23

Molecular structure of F-actin and location of surface binding sites. Nature (1990) 3.18

Tropomyosin crystal structure and muscle regulation. J Mol Biol (1986) 2.65

Ca(2+)-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction. Nature (1994) 2.34

Regulation of skeletal muscle contraction. II. Structural studies of the interaction of the tropomyosin-troponin complex with actin. J Mol Biol (1972) 2.17

Deciphering the design of the tropomyosin molecule. Proc Natl Acad Sci U S A (2001) 2.14

Gestalt-binding of tropomyosin to actin filaments. J Muscle Res Cell Motil (2008) 1.86

An atomic model of the unregulated thin filament obtained by X-ray fiber diffraction on oriented actin-tropomyosin gels. J Mol Biol (1995) 1.83

Crystal structure of tropomyosin at 7 Angstroms resolution. Proteins (2000) 1.76

Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry. Biophys J (2011) 1.76

The shape and flexibility of tropomyosin coiled coils: implications for actin filament assembly and regulation. J Mol Biol (2009) 1.75

Analysis of the primary sequence of alpha-tropomyosin from rabbit skeletal muscle. J Mol Biol (1975) 1.74

X-ray diffraction evidence for alpha-helical coiled-coils in native muscle. J Mol Biol (1963) 1.71

Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function. Adv Protein Chem (2005) 1.66

Structure of the F-actin-tropomyosin complex. Nature (2014) 1.61

Solution NMR structure of the junction between tropomyosin molecules: implications for actin binding and regulation. J Mol Biol (2006) 1.52

Troponin and its interactions with tropomyosin. An electron microscope study. J Mol Biol (1982) 1.48

Role of proline in polypeptide chain configuration of proteins. Science (1957) 1.39

Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding. Biochemistry (2003) 1.38

Conserved Asp-137 imparts flexibility to tropomyosin and affects function. J Biol Chem (2007) 1.30

The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coil. J Struct Biol (2010) 1.27

Semirational design of Jun-Fos coiled coils with increased affinity: Universal implications for leucine zipper prediction and design. Proc Natl Acad Sci U S A (2006) 1.27

X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle. Proc Natl Acad Sci U S A (2010) 1.25

THE STRUCTURE OF ACTIN FILAMENTS AND THE ORIGIN OF THE AXIAL PERIODICITY IN THE I-SUBSTANCE OF VERTEBRATE STRIATED MUSCLE. Proc R Soc Lond B Biol Sci (1964) 1.25

Crystal structures of tropomyosin: flexible coiled-coil. Adv Exp Med Biol (2007) 1.23

Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands. Biophys J (2010) 1.22

Tropomyosin: function follows structure. Adv Exp Med Biol (2008) 1.14

Tropomyosin - master regulator of actin filament function in the cytoskeleton. J Cell Sci (2015) 1.13

Tropomyosin: a new asymmetric protein component of muscle. Nature (1946) 1.06

A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin. J Biol Chem (2013) 1.04

Three-dimensional reconstruction of caldesmon-containing smooth muscle thin filaments. J Cell Biol (1993) 1.02

Formins determine the functional properties of actin filaments in yeast. Curr Biol (2014) 1.01

Persistence length of human cardiac α-tropomyosin measured by single molecule direct probe microscopy. PLoS One (2012) 0.99

Tropomyosin: double helix from the protein world. Biochemistry (Mosc) (2011) 0.97

Curvature variation along the tropomyosin molecule. J Struct Biol (2009) 0.97

The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules. Arch Biochem Biophys (2013) 0.93

Generalized facilitated diffusion model for DNA-binding proteins with search and recognition states. Biophys J (2012) 0.93

An atomic model of the tropomyosin cable on F-actin. Biophys J (2014) 0.91

The interaction of alpha, alpha- and alpha , beta-tropomyosin with actin filaments. FEBS Lett (1980) 0.89

The binding dynamics of tropomyosin on actin. Biophys J (2001) 0.88

Arp2/3 complex and cofilin modulate binding of tropomyosin to branched actin networks. Curr Biol (2015) 0.87

Visualization of monoclonal antibody binding to tropomyosin on native smooth muscle thin filaments by electron microscopy. J Mol Biol (1982) 0.87

Probing the flexibility of tropomyosin and its binding to filamentous actin using molecular dynamics simulations. Biophys J (2013) 0.85

Selectional and mutational scope of peptides sequestering the Jun-Fos coiled-coil domain. J Mol Biol (2008) 0.83

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. J Muscle Res Cell Motil (2015) 0.83

Direct observation of tropomyosin binding to actin filaments. Cytoskeleton (Hoboken) (2015) 0.81