Lipid metabolic reprogramming in cancer cells.

Oxygen availability and metabolic reprogramming in cancer. J Biol Chem (2017) 0.92

Functional role of extracellular vesicles and lipoproteins in the tumour microenvironment. Philos Trans R Soc Lond B Biol Sci (2018) 0.80

Preoperative blood-routine markers and prognosis of esophageal squamous cell carcinoma: The Fujian prospective investigation of cancer (FIESTA) study. Oncotarget (2016) 0.80

Potential of Diffusion-Weighted Imaging in the Characterization of Malignant, Benign, and Healthy Breast Tissues and Molecular Subtypes of Breast Cancer. Front Oncol (2016) 0.80

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat Rev Endocrinol (2017) 0.80

p53 as a Regulator of Lipid Metabolism in Cancer. Int J Mol Sci (2016) 0.79

Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab (2016) 0.77

Lipid Droplets: A Key Cellular Organelle Associated with Cancer Cell Survival under Normoxia and Hypoxia. Int J Mol Sci (2016) 0.76

Aberrant Lipid Metabolism Promotes Prostate Cancer: Role in Cell Survival under Hypoxia and Extracellular Vesicles Biogenesis. Int J Mol Sci (2016) 0.76

Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells. Metabolites (2016) 0.76

Drug Repurposing of the Anthelmintic Niclosamide to Treat Multidrug-Resistant Leukemia. Front Pharmacol (2017) 0.75

The Effect of Immunonutrition on the Postoperative Complications in Thymoma with Myasthenia Gravis. Mediators Inflamm (2016) 0.75

Unsaturated fatty acids regulate stemness of ovarian cancer cells through NF-κB. Stem Cell Investig (2017) 0.75

Integrating a prospective pilot trial and patient-derived xenografts to trace metabolic changes associated with acute myeloid leukemia. J Hematol Oncol (2016) 0.75

Lipid Osteoclastokines Regulate Breast Cancer Bone Metastasis. Endocrinology (2016) 0.75

Targeting the Metabolic Reprogramming That Controls Epithelial-to-Mesenchymal Transition in Aggressive Tumors. Front Oncol (2017) 0.75

Extracellular Proton Concentrations Impacts LN229 Glioblastoma Tumor Cell Fate via Differential Modulation of Surface Lipids. Front Oncol (2017) 0.75

Lipidomic Profiling of Lung Pleural Effusion Identifies Unique Metabotype for EGFR Mutants in Non-Small Cell Lung Cancer. Sci Rep (2016) 0.75

Insights into the Regulatory Role of Non-coding RNAs in Cancer Metabolism. Front Physiol (2016) 0.75

Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133. Sci Rep (2017) 0.75

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy. Front Oncol (2017) 0.75

Three serum metabolite signatures for diagnosing low-grade and high-grade bladder cancer. Sci Rep (2017) 0.75

Loss-of-function screens of druggable targetome against cancer stem-like cells. FASEB J (2016) 0.75

Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging. J Am Soc Mass Spectrom (2016) 0.75

Influence of Cholesterol on the Oxygen Permeability of Membranes: Insight from Atomistic Simulations. Biophys J (2017) 0.75

Addressing metabolic heterogeneity in clear cell renal cell carcinoma with quantitative Dixon MRI. JCI Insight (2017) 0.75

The 9th Conference on Metal Toxicity and Carcinogenesis: The conference overview. Toxicol Appl Pharmacol (2017) 0.75

The Role of miRNAs in Angiogenesis, Invasion and Metabolism and Their Therapeutic Implications in Gliomas. Cancers (Basel) (2017) 0.75

Endothelial cell metabolism in health and disease: impact of hypoxia. EMBO J (2017) 0.75

Molecular features that predict the response to antimetabolite chemotherapies. Cancer Metab (2017) 0.75

Increased utilization of fructose has a positive effect on the development of breast cancer. PeerJ (2017) 0.75

Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism. Metab Eng (2017) 0.75

"Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. Int J Mol Sci (2017) 0.75

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy. Cell Metab (2017) 0.75

Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer. Redox Biol (2017) 0.75

Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer. Breast Cancer (Auckl) (2017) 0.75

Multicellular tumor spheroids of human uveal melanoma induce genes associated with anoikis resistance, lipogenesis, and SSXs. Mol Vis (2017) 0.75

Repurposing itraconazole as an anticancer agent. Oncol Lett (2017) 0.75

Cancer: Untethering Mitochondria from the Endoplasmic Reticulum? Front Oncol (2017) 0.75

Significance of long chain polyunsaturated fatty acids in human health. Clin Transl Med (2017) 0.75

Hallmarks of cancer: the next generation. Cell (2011) 140.01

On the origin of cancer cells. Science (1956) 49.55

Lipid rafts as a membrane-organizing principle. Science (2010) 13.48

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer (2007) 10.20

Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell (2012) 8.71

ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell (2005) 7.65

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell (2012) 7.36

Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell (1998) 7.25

The PI3K pathway as drug target in human cancer. J Clin Oncol (2010) 6.83

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature (2013) 6.53

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15

Eicosanoids and cancer. Nat Rev Cancer (2010) 5.96

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood (2006) 5.21

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature (2013) 4.71

Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res (2007) 4.69

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell (2006) 4.13

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res (2006) 3.64

Fatty acid synthase and cancer: new application of an old pathway. Cancer Res (2006) 3.37

Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell (2012) 3.24

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J Clin Invest (2009) 3.23

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth. Mol Syst Biol (2011) 3.15

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97

Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest (2005) 2.89

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J Clin Invest (2009) 2.80

The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene (2009) 2.72

Induction of myeloid-derived suppressor cells by tumor exosomes. Int J Cancer (2009) 2.64

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A (2013) 2.57

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature (2014) 2.52

Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol (2015) 2.35

Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. Cell Metab (2014) 2.35

Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A (2003) 2.23

Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. Am J Pathol (2006) 2.21

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. Cancer Cell (2015) 2.21

Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells. Endocrinology (2015) 2.14

Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res (2011) 2.07

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol (2011) 2.02

Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol (2010) 2.00

Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion. Int J Cancer (2007) 2.00

Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res (2013) 2.00

Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res (2006) 1.98

Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell (2012) 1.98

The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells. Cancer Cell (2006) 1.85

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins. J Lipid Res (2010) 1.82

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell (2015) 1.81

An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov (2011) 1.77

Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem Cells (2015) 1.75

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci U S A (2013) 1.73

Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci U S A (2015) 1.69

Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Res (2006) 1.66

Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. Nat Rev Drug Discov (2013) 1.66

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res (2007) 1.64

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma. Cancer Discov (2015) 1.62

Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies. Biochim Biophys Acta (2013) 1.62

Lipid rafts: signaling and sorting platforms of cells and their roles in cancer. Expert Rev Proteomics (2011) 1.60

De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res (2010) 1.59

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. Curr Biol (2002) 1.56

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis Model Mech (2013) 1.55

Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther (2007) 1.55

Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer (2008) 1.55

Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncol (2010) 1.53

Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. Clin Cancer Res (2015) 1.53

Lipid droplets in inflammation and cancer. Prostaglandins Leukot Essent Fatty Acids (2010) 1.52

Targeting the leukemia cell metabolism by the CPT1a inhibition: functional preclinical effects in leukemias. Blood (2015) 1.51

Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts. Blood (2006) 1.49

Decrease in membrane phospholipid unsaturation induces unfolded protein response. J Biol Chem (2010) 1.48

ATP-citrate lyase: a key player in cancer metabolism. Cancer Res (2012) 1.48

Targeting tumor cell metabolism with statins. Oncogene (2012) 1.46

Cannabinoids for cancer treatment: progress and promise. Cancer Res (2008) 1.46

Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Cancer Res (2008) 1.45

Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res (2007) 1.45

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. J Lipid Res (2008) 1.44

Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy. J Lipid Res (2010) 1.35

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim Biophys Acta (2013) 1.35

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab (2013) 1.35

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. Trends Cell Biol (2014) 1.34

Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Cancer Res (2007) 1.31

Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells. Oncogene (2010) 1.31

Multifaceted roles of PGE2 in inflammation and cancer. Semin Immunopathol (2012) 1.29

Aspirin and COX-2 inhibitor use in patients with stage III colon cancer. J Natl Cancer Inst (2014) 1.28

Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des (2013) 1.22

Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions. Mol Cancer Ther (2006) 1.22

Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. Cell Death Differ (2007) 1.21

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. Cancer Res (2008) 1.21

Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer. Cancer (1994) 1.20

Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene (2004) 1.19

COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models. Sci Transl Med (2014) 1.19

Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach. Anticancer Res (2010) 1.18

Biochemical changes in tumor tissues of oral cancer patients. Clin Biochem (2003) 1.18

A combined preclinical therapy of cannabinoids and temozolomide against glioma. Mol Cancer Ther (2011) 1.17

Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro. FASEB J (2010) 1.16

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res (2013) 1.12

Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles. J Phys Chem B (2007) 1.12

The role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics. Front Pharmacol (2013) 1.11

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism. Proc Natl Acad Sci U S A (2015) 1.07

Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer. Mol Cancer Ther (2003) 1.07

Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. PLoS One (2009) 1.05

Stress responses from the endoplasmic reticulum in cancer. Front Oncol (2015) 1.03

Lipid catabolism via CPT1 as a therapeutic target for prostate cancer. Mol Cancer Ther (2014) 1.03

Alteration of the lipid profile in lymphomas induced by MYC overexpression. Proc Natl Acad Sci U S A (2014) 1.00