Published in Mol Neurodegener on January 26, 2016
Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations. Int J Mol Sci (2016) 0.75
Trapping the oligomers: new promises in neurosciences. Oncotarget (2016) 0.75
Plasma cholesterol level determines in vivo prion propagation. J Lipid Res (2017) 0.75
Novel proteinaceous infectious particles cause scrapie. Science (1982) 24.09
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins. Proc Natl Acad Sci U S A (1993) 10.36
Eight prion strains have PrP(Sc) molecules with different conformations. Nat Med (1998) 9.01
Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu Rev Neurosci (2003) 8.44
Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay. Lancet (2001) 5.57
Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy. Biochemistry (1991) 5.53
The most infectious prion protein particles. Nature (2005) 5.37
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell (1989) 4.73
Linkage of prion protein and scrapie incubation time genes. Cell (1986) 3.69
A novel human disease with abnormal prion protein sensitive to protease. Ann Neurol (2008) 2.95
In vitro conversion of full-length mammalian prion protein produces amyloid form with physical properties of PrP(Sc). J Mol Biol (2004) 2.59
Protease-sensitive scrapie prion protein in aggregates of heterogeneous sizes. Biochemistry (2002) 2.36
Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J Virol (2000) 2.18
Diagnosis of human prion disease. Proc Natl Acad Sci U S A (2005) 2.13
Isolation and characterization of a proteinase K-sensitive PrPSc fraction. Biochemistry (2006) 1.86
Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein. Ann Neurol (2010) 1.66
Structure-based drug design identifies polythiophenes as antiprion compounds. Sci Transl Med (2015) 1.64
The same primary structure of the prion protein yields two distinct self-propagating states. J Biol Chem (2008) 1.64
In vitro and in vivo neurotoxicity of prion protein oligomers. PLoS Pathog (2007) 1.56
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
High yield purification and physico-chemical properties of full-length recombinant allelic variants of sheep prion protein linked to scrapie susceptibility. Eur J Biochem (2000) 1.35
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34
Two amyloid States of the prion protein display significantly different folding patterns. J Mol Biol (2010) 1.16
A case of protease sensitive prionopathy in a patient in the UK. Neuropathol Appl Neurobiol (2009) 1.10
Anti-PrP antibodies block PrPSc replication in prion-infected cell cultures by accelerating PrPC degradation. J Neurochem (2004) 1.04
The first case of protease-sensitive prionopathy (PSPr) in The Netherlands: a patient with an unusual GSS-like clinical phenotype. J Neurol Neurosurg Psychiatry (2010) 1.04
Molecular pathology of human prion diseases. Int J Mol Sci (2009) 0.94
Effective gene therapy in a mouse model of prion diseases. PLoS One (2008) 0.92
Therapeutic approaches for prion disorders. Expert Rev Anti Infect Ther (2007) 0.90
Oligomeric-induced activity by thienyl pyrimidine compounds traps prion infectivity. J Neurosci (2011) 0.88
Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts. Chemistry (2014) 0.85
Full-length prion protein aggregates to amyloid fibrils and spherical particles by distinct pathways. FEBS J (2008) 0.84
Ferulic acid inhibits the transition of amyloid-β42 monomers to oligomers but accelerates the transition from oligomers to fibrils. J Alzheimers Dis (2013) 0.80
Thienyl pyrimidine derivatives with PrP(Sc) oligomer-inducing activity are a promising tool to study prions. Curr Top Med Chem (2013) 0.78