Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi's Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 26814175)

Published in MBio on January 26, 2016

Authors

Myung-Shin Lee1, Hongfeng Yuan2, Hyungtaek Jeon3, Ying Zhu2, Seungmin Yoo3, Songtao Shi4, Brian Krueger5, Rolf Renne5, Chun Lu6, Jae U Jung2, Shou-Jiang Gao7

Author Affiliations

1: Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, Republic of Korea Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
2: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
3: Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon, Republic of Korea.
4: Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
5: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
6: Department of Microbiology, Nanjing Medical University, Nanjing, People's Republic of China.
7: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA shoujiag@usc.edu.

Articles cited by this

Multilineage potential of adult human mesenchymal stem cells. Science (1999) 66.19

Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J (1996) 16.68

Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci (2006) 8.09

Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet (2004) 7.84

SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A (2003) 6.80

Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell (2008) 6.26

The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med (2005) 5.95

Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells (2007) 5.83

PI3K/Akt signalling pathway and cancer. Cancer Treat Rev (2004) 5.46

Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res (2003) 5.23

Primary characterization of a herpesvirus agent associated with Kaposi's sarcomae. J Virol (1996) 5.05

Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res (2002) 4.83

Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells (2004) 4.79

Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol (1966) 4.55

Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med (1996) 4.13

Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood (2003) 4.09

Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther (2007) 3.97

Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. N Engl J Med (1996) 3.61

Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet (2004) 3.38

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets (2008) 3.36

Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone. J Cell Biol (1988) 2.73

Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells (2009) 2.68

KSHV and the pathogenesis of Kaposi sarcoma: listening to human biology and medicine. J Clin Invest (2010) 2.55

Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat Genet (2004) 2.47

Immunobiology of mesenchymal stem cells. Cell Death Differ (2013) 2.18

PI3K/AKT/mTOR Pathway in Angiogenesis. Front Mol Neurosci (2011) 2.06

Construction and manipulation of a new Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome clone. J Virol (2012) 1.89

Productive lytic replication of a recombinant Kaposi's sarcoma-associated herpesvirus in efficient primary infection of primary human endothelial cells. J Virol (2003) 1.70

Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Cancer Res (2008) 1.57

Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation. Virology (2004) 1.57

Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A (2004) 1.52

Early and sustained expression of latent and host modulating genes in coordinated transcriptional program of KSHV productive primary infection of human primary endothelial cells. Virology (2005) 1.42

Gammaherpesvirus and lymphoproliferative disorders in immunocompromised patients. Cancer Lett (2011) 1.41

Histological variants of cutaneous Kaposi sarcoma. Diagn Pathol (2008) 1.36

In vitro endothelial potential of human UC blood-derived mesenchymal stem cells. Cytotherapy (2006) 1.23

Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo. Circulation (2008) 1.22

Dilution of human mesenchymal stem cells with dermal fibroblasts and the effects on in vitro and in vivo osteochondrogenesis. Dev Dyn (2000) 1.21

Phosphorylation of AKT: a mutational analysis. Oncotarget (2011) 1.17

Human peripheral blood derived mesenchymal stem cells demonstrate similar characteristics and chondrogenic differentiation potential to bone marrow derived mesenchymal stem cells. J Orthop Res (2011) 1.16

Mesenchymal stem cell-secreted soluble signaling molecules potentiate tumor growth. Cell Cycle (2011) 1.12

γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis. Curr Opin Virol (2013) 1.10

Human oral mucosa and gingiva: a unique reservoir for mesenchymal stem cells. J Dent Res (2012) 1.09

KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways. PLoS Pathog (2013) 1.08

Bone marrow findings in HIV-positive patients with Kaposi sarcoma herpesvirus-associated multicentric Castleman disease. Am J Clin Pathol (2013) 1.06

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell (2011) 1.06

Human herpesvirus 8 seroprevalence and evaluation of nonsexual transmission routes by detection of DNA in clinical specimens from human immunodeficiency virus-seronegative patients from central and southern Italy, with and without Kaposi's sarcoma. J Clin Microbiol (1999) 1.05

Kaposi's sarcoma herpesvirus-like DNA sequences in the saliva of individuals infected with human immunodeficiency virus. Clin Infect Dis (1996) 1.05

Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells. J Dent Res (2013) 1.04

Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J Clin Invest (2012) 1.01

The wound healing, chronic fibrosis, and cancer progression triad. Physiol Genomics (2014) 0.99

Neural cell differentiation in vitro from adult human bone marrow mesenchymal stem cells. Stem Cells Dev (2005) 0.98

Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms. Stem Cells (2011) 0.98

Platelet-derived growth factor receptors regulate mesenchymal stem cell fate: implications for neovascularization. Expert Opin Biol Ther (2010) 0.97

Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. Am J Pathol (1994) 0.97

Mesenchymal-to-endothelial transition in Kaposi sarcoma: a histogenetic hypothesis based on a case series and literature review. PLoS One (2013) 0.97

Myogenic cells in Kaposi's sarcoma: an ultrastructural study. J Pathol (1978) 0.96

Susceptibility of human fetal mesenchymal stem cells to Kaposi sarcoma-associated herpesvirus. Blood (2004) 0.95

Phenotypic characteristics of Kaposi's sarcoma tumour cells derived from patch-, plaque- and nodular-stage lesions: analysis of cell cultures isolated from AIDS and non-AIDS patients and review of the literature. Br J Dermatol (2000) 0.94

Efficiently differentiating vascular endothelial cells from adipose tissue-derived mesenchymal stem cells in serum-free culture. Biochem Biophys Res Commun (2010) 0.94

Molecular and ultrastructural characterization of endothelial cells differentiated from human bone marrow mesenchymal stem cells. Cell Biol Int (2008) 0.93

Centrifugal enhancement of Kaposi's sarcoma-associated virus infection of human endothelial cells in vitro. J Virol Methods (2008) 0.91

Maintenance and proliferation control of primitive hemopoietic progenitors in long-term cultures of human marrow cells. Blood Cells (1988) 0.88

Oncostatin M promotes mesenchymal stem cell-stimulated tumor growth through a paracrine mechanism involving periostin and TGFBI. Int J Biochem Cell Biol (2013) 0.87

Oral malignancies in HIV disease: changes in disease presentation, increasing understanding of molecular pathogenesis, and current management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2005) 0.87

Immunocytochemical profile of Kaposi's sarcoma cells: their reactivity to a panel of antibodies directed against different tissue cell markers. Appl Pathol (1989) 0.86

Detection and characterization of human herpesvirus-8-infected cells in bone marrow biopsies of human immunodeficiency virus-positive patients. Hum Pathol (2001) 0.86

Exploitation of the complement system by oncogenic Kaposi's sarcoma-associated herpesvirus for cell survival and persistent infection. PLoS Pathog (2014) 0.86

KSHV miRNAs decrease expression of lytic genes in latently infected PEL and endothelial cells by targeting host transcription factors. Viruses (2014) 0.85

A KSHV microRNA Directly Targets G Protein-Coupled Receptor Kinase 2 to Promote the Migration and Invasion of Endothelial Cells by Inducing CXCR2 and Activating AKT Signaling. PLoS Pathog (2015) 0.84

Outlook in oral and cutaneous Kaposi's sarcoma. Lancet (2001) 0.84

Genotypic profile of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) in urine. J Clin Microbiol (2004) 0.83

Tumor promotion through the mesenchymal stem cell compartment in human hepatocellular carcinoma. Carcinogenesis (2013) 0.83

Mesenchymal stem cells from the oral cavity and their potential value in tissue engineering. Periodontol 2000 (2015) 0.81

Mesenchymal stem cell-tumor cell cooperation in breast cancer vasculogenesis. Mol Med Rep (2012) 0.81

Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth. Int J Biochem Cell Biol (2012) 0.81

Expression of the fibroblast/macrophage marker 1B10 by spindle cells in Kaposi's sarcoma lesions and by Kaposi's sarcoma-derived tumor cells. J Cutan Pathol (2002) 0.79

Kaposi's sarcoma-associated herpesvirus downregulates transforming growth factor β2 to promote enhanced stability of capillary-like tube formation. J Virol (2014) 0.79

Kaposi's sarcoma-associated herpesvirus microRNAs repress breakpoint cluster region protein expression, enhance Rac1 activity, and increase in vitro angiogenesis. J Virol (2015) 0.79

Induction of mesenchymal to endothelial transformation of adipose-derived stem cells. J Heart Valve Dis (2010) 0.78

Role of host microRNAs in Kaposi's sarcoma-associated herpesvirus pathogenesis. Viruses (2014) 0.78

Kaposi's sarcoma-associated herpesvirus infection of human bone-marrow-derived mesenchymal stem cells and their angiogenic potential. Arch Virol (2014) 0.76

Mixed haematopoietic colony formation via immature blast cell clusters on foetal mesenchymal cell layers distinguishes stem cells from peripheral blood, cord blood, bone marrow and blood stem cells mobilized by granulocyte-macrophage colony-stimulating factor. Eur J Haematol (1995) 0.75