Published in Arterioscler Thromb Vasc Biol on February 01, 2016
Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ. Nat Commun (2017) 0.75
Low-Density Lipoprotein Receptor-Related Protein-1 Signaling in Angiogenesis. Front Cardiovasc Med (2017) 0.75
Cell cycle checkpoints: preventing an identity crisis. Science (1996) 13.74
Molecular mechanisms and clinical applications of angiogenesis. Nature (2011) 13.36
Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol (2006) 9.58
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest (2000) 5.48
LRP: a multifunctional scavenger and signaling receptor. J Clin Invest (2001) 5.31
Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest (2000) 5.07
Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci (1995) 4.97
A family of human cdc2-related protein kinases. EMBO J (1992) 4.96
Retinal angiogenesis in development and disease. Nature (2005) 4.18
Angiogenesis: a team effort coordinated by notch. Dev Cell (2009) 4.05
LRP: role in vascular wall integrity and protection from atherosclerosis. Science (2003) 3.89
LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev (2008) 3.46
Poly(ADP-ribose) is required for spindle assembly and structure. Nature (2004) 3.11
The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders. Cell Mol Life Sci (2002) 2.61
Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest (2000) 2.11
PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol (2003) 2.08
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell (2010) 2.01
Candidate genes for the hypoxic tumor phenotype. Cancer Res (2000) 1.94
Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res (1992) 1.90
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem (2002) 1.83
Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc Natl Acad Sci U S A (1992) 1.72
Molecular mechanisms of lipoprotein receptor signalling. Cell Mol Life Sci (2005) 1.53
The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev (1994) 1.38
Gamma-secretase limits the inflammatory response through the processing of LRP1. Sci Signal (2008) 1.38
CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells. Genes Dev (2012) 1.24
Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process. Stroke (2005) 1.18
LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiol Dis (2008) 1.15
The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer Res (2007) 1.14
Correction: LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell (1993) 1.04
Signaling through LRP1: Protection from atherosclerosis and beyond. Biochem Pharmacol (2010) 1.03
PolyADP-ribosylation is required for long-term memory formation in mammals. J Neurochem (2009) 1.03
LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis. Circ Res (2012) 0.99
Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J Cell Sci (2004) 0.99
LRP1 protects the vasculature by regulating levels of connective tissue growth factor and HtrA1. Arterioscler Thromb Vasc Biol (2013) 0.96
Endothelial LRP1 transports amyloid-β1-42 across the blood-brain barrier. J Clin Invest (2015) 0.93
Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-beta peptide(1-40) in mouse: involvement of an LRP-1-independent pathway. J Neurochem (2010) 0.92
Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol (2006) 0.91
Hypoxia stimulates low-density lipoprotein receptor-related protein-1 expression through hypoxia-inducible factor-1α in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2011) 0.90
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. Development (2014) 0.86
LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation. Arterioscler Thromb Vasc Biol (2015) 0.82
Diversity is in my veins: role of bone morphogenetic protein signaling during venous morphogenesis in zebrafish illustrates the heterogeneity within endothelial cells. Arterioscler Thromb Vasc Biol (2014) 0.81