Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo.

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Published in Nat Biotechnol on February 01, 2016

Authors

Hao Yin1, Chun-Qing Song2,3, Joseph R Dorkin1,4, Lihua J Zhu3,5,6, Yingxiang Li7, Qiongqiong Wu1, Angela Park2, Junghoon Yang1, Sneha Suresh1, Aizhan Bizhanova2, Ankit Gupta5, Mehmet F Bolukbasi5,8, Stephen Walsh1, Roman L Bogorad1, Guangping Gao9, Zhiping Weng6, Yizhou Dong10, Victor Koteliansky11,12, Scot A Wolfe5,8, Robert Langer1,13,14,15, Wen Xue2,3,5, Daniel G Anderson1,13,14,15

Author Affiliations

1: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
2: RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
3: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
4: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
5: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
6: Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
7: Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, P.R. China.
8: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
9: Gene Therapy Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
10: College of Pharmacy, the Ohio State University, Columbus, Ohio, USA.
11: Skolkovo Institute of Science and Technology, Skolkovo, Russia.
12: Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory, Russia.
13: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
14: Harvard-MIT Division of Health Sciences &Technology, Cambridge, Massachusetts, USA.
15: Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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