Context-dependent mechanisms modulating aldosterone signaling in the kidney.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 26846783)

Published in Clin Exp Nephrol on February 05, 2016

Authors

Shigeru Shibata1,2

Author Affiliations

1: Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan. shigeru.shibata@med.teikyo-u.ac.jp.
2: Division of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. shigeru.shibata@med.teikyo-u.ac.jp.

Articles citing this

Clinical features and molecular basis of pseudohypoaldosteronism type 1. Clin Pediatr Endocrinol (2017) 0.75

Articles cited by this

Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med (2003) 13.25

Molecular mechanisms of human hypertension. Cell (2001) 11.17

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet (2015) 7.34

K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science (2011) 5.40

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial. JAMA (2015) 4.63

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature (2012) 4.26

Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Nat Genet (1999) 3.73

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58

Crystal structure of an ancient protein: evolution by conformational epistasis. Science (2007) 3.56

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. J Cell Sci (2008) 3.07

Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A (2001) 2.97

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet (2013) 2.83

The thiazide-sensitive Na-Cl cotransporter is an aldosterone-induced protein. Proc Natl Acad Sci U S A (1998) 2.79

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell (2011) 2.75

Functional interactions between Stat5 and the glucocorticoid receptor. Nature (1996) 2.64

Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension. Nat Genet (2013) 2.63

Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Physiol Rev (2004) 2.36

The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest (2010) 2.28

Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone. Kidney Int (2010) 2.27

Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat Med (2008) 2.25

Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nat Genet (2013) 2.09

Sites of regulated phosphorylation that control K-Cl cotransporter activity. Cell (2009) 1.93

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat Genet (2012) 1.93

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int (2008) 1.92

Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney Int (2013) 1.80

Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia. Cell Metab (2013) 1.72

Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha. J Clin Invest (2007) 1.69

Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride. Cell Metab (2015) 1.59

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci U S A (2013) 1.56

Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol (2014) 1.55

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep (2013) 1.52

The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A (2005) 1.51

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J (2013) 1.49

NaCl restriction upregulates renal Slc26a4 through subcellular redistribution: role in Cl- conservation. Hypertension (2004) 1.49

"Salt-sensitive" essential hypertension in men. Is the sodium ion alone important? N Engl J Med (1987) 1.48

SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A (2008) 1.46

Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport. Am J Physiol Renal Physiol (2002) 1.42

Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. Am J Physiol (1996) 1.37

Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension. Hypertension (2003) 1.36

Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci U S A (2010) 1.36

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway. J Clin Invest (2011) 1.35

Regulation of prostasin by aldosterone in the kidney. J Clin Invest (2002) 1.33

Chloride sensing by WNK1 involves inhibition of autophosphorylation. Sci Signal (2014) 1.33

Localization of thiazide-sensitive Na(+)-Cl(-) cotransport and associated gene products in mouse DCT. Am J Physiol Renal Physiol (2001) 1.29

Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol (2014) 1.18

Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure. Proc Natl Acad Sci U S A (2012) 1.16

Thiazide-sensitive NaCl absorption in rat cortical collecting duct. Am J Physiol (1990) 1.16

Renal β-intercalated cells maintain body fluid and electrolyte balance. J Clin Invest (2013) 1.13

The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride. J Am Soc Nephrol (2014) 1.12

In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. Am J Physiol Renal Physiol (2010) 1.10

Renal intercalated cells are rather energized by a proton than a sodium pump. Proc Natl Acad Sci U S A (2013) 1.09

Role of chloride in angiotensin II-induced salt-sensitive hypertension. Hypertension (1991) 1.08

Dietary chloride as a determinant of "sodium-dependent" hypertension. Science (1983) 1.07

Overexpression and characterization of the human mineralocorticoid receptor. J Biol Chem (1991) 1.06

Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators. J Clin Invest (2012) 1.05

Profound hypokalemia and hypochloremic metabolic alkalosis during thiazide therapy in a child with Pendred syndrome. Clin Nephrol (2008) 1.03

Salt-sensitive hypertension: contribution of chloride. Science (1984) 1.03

Modulation of NCC activity by low and high K(+) intake: insights into the signaling pathways involved. Am J Physiol Renal Physiol (2014) 1.02

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nat Genet (2015) 1.02

Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism. Elife (2015) 1.01

A randomized crossover study to compare the blood pressure response to sodium loading with and without chloride in patients with essential hypertension. J Hypertens (1988) 1.01

Overexpression of pendrin in intercalated cells produces chloride-sensitive hypertension. J Am Soc Nephrol (2013) 0.99

Mineralocorticoid receptor-associated hypertension and its organ damage: clinical relevance for resistant hypertension. Am J Hypertens (2012) 0.97

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation. FEBS Lett (2013) 0.97

Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport. J Am Soc Nephrol (2015) 0.96

Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor. Mol Endocrinol (2010) 0.96

Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proc Natl Acad Sci U S A (2014) 0.95

Effects of angiotensin II on kinase-mediated sodium and potassium transport in the distal nephron. Curr Opin Nephrol Hypertens (2013) 0.95

KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A (2015) 0.95

Principal cells of cortical collecting ducts of the rat are not a route of transepithelial Cl- transport. Pflugers Arch (1990) 0.93

Mechanisms of renal control of potassium homeostasis in complete aldosterone deficiency. J Am Soc Nephrol (2014) 0.93

Molecular cloning and characterization of Atp6v1b1, the murine vacuolar H+ -ATPase B1-subunit. Gene (2003) 0.93

Cortical distal nephron Cl(-) transport in volume homeostasis and blood pressure regulation. Am J Physiol Renal Physiol (2013) 0.92

Effects of aldosterone on NEM-sensitive ATPase in rabbit nephron segments. Kidney Int (1988) 0.89

A trail of research on potassium. Kidney Int (2002) 0.88

Differential ubiquitylation of the mineralocorticoid receptor is regulated by phosphorylation. FASEB J (2012) 0.87

Native rat kidney mineralocorticoid receptor is a phosphoprotein whose transformation to a DNA-binding form is induced by phosphatases. Biochem J (1998) 0.87

Immunolocalization of NAD-dependent 11 beta-hydroxysteroid dehydrogenase in human kidney and colon. Kidney Int (1996) 0.86

Aldosterone requires vasopressin V1a receptors on intercalated cells to mediate acid-base homeostasis. J Am Soc Nephrol (2011) 0.86

Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone. PLoS One (2013) 0.84

Mineralocorticoid receptors in the pathophysiology of chronic kidney diseases and the metabolic syndrome. Mol Cell Endocrinol (2011) 0.84

The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension. Curr Hypertens Rep (2011) 0.79

A mathematical model of rat collecting duct. III. Paradigms for distal acidification defects. Am J Physiol Renal Physiol (2002) 0.78

Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit. J Am Soc Nephrol (2015) 0.78

Effect of mineralocorticoids on acid-base balance. Nephron Physiol (2014) 0.76