GFI1 as a novel prognostic and therapeutic factor for AML/MDS.

Tobacco smoking differently influences cell types of the innate and adaptive immune system-indications from CpG site methylation. Clin Epigenetics (2016) 0.84

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome. Exp Hematol (2016) 0.75

Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1. PLoS One (2016) 0.75

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Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature (2003) 12.06

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90

Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med (2004) 11.61

Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. N Engl J Med (2004) 9.81

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Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med (2011) 5.24

Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell (2010) 5.05

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature (2004) 4.68

Histone deacetylase inhibitors in cancer therapy. J Clin Oncol (2009) 4.58

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet (2004) 4.45

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Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity (2003) 3.17

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Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica (2008) 3.06

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Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet (2002) 2.87

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood (2009) 2.86

Unraveling the molecular pathophysiology of myelodysplastic syndromes. J Clin Oncol (2011) 2.69

Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell (2007) 2.62

Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J (2004) 2.57

Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet (2003) 2.43

Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells. Cancer Cell (2008) 2.35

NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. Blood (2005) 2.03

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A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia. J Clin Invest (2007) 1.63

Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development. J Biol Chem (2004) 1.56

A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity (2009) 1.55

RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation. Leukemia (2009) 1.35

Gfi1 and Gfi1b: key regulators of hematopoiesis. Leukemia (2010) 1.32

Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion. Proc Natl Acad Sci U S A (2006) 1.32

Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. Immunity (2008) 1.27

Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. J Cell Biochem (2003) 1.26

High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells. Oncogene (2002) 1.26

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development. EMBO Rep (2006) 1.21

Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr Opin Hematol (2006) 1.21

Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood (2009) 1.11

Gfi1 integrates progenitor versus granulocytic transcriptional programming. Blood (2009) 1.11

Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. J Biol Chem (2008) 1.10

Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia. Cell Stem Cell (2015) 1.09

A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome. Br J Haematol (2014) 1.08

Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents. Cytogenet Cell Genet (1995) 1.05

Gfi1-cells and circuits: unraveling transcriptional networks of development and disease. Curr Opin Hematol (2010) 1.01

Vorinostat induces apoptosis and differentiation in myeloid malignancies: genetic and molecular mechanisms. PLoS One (2013) 0.95

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice. Blood (2012) 0.95

Progression of myelodysplastic syndrome: allelic loss on chromosomal arm 1p. Br J Haematol (2003) 0.92

Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia. Leukemia (2014) 0.92

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell (2013) 0.91

Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function. Eur J Immunol (2007) 0.91

Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1. Blood (2007) 0.89

Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A. Chem Biol (2010) 0.88

Retracted Transcriptional repressor Gfi1 integrates cytokine-receptor signals controlling B-cell differentiation. PLoS One (2007) 0.88

CD34, RAB20, PU.1 and GFI1 mRNA expression in myelodysplastic syndrome. Int J Lab Hematol (2008) 0.86

Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation. Leukemia (2013) 0.85

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors. PLoS Genet (2013) 0.83

Validation of the IPSS-R in lenalidomide-treated, lower-risk myelodysplastic syndrome patients with del(5q). Blood Cancer J (2014) 0.82

Epigenetic control of hematopoiesis: the PU.1 chromatin connection. Biol Chem (2014) 0.80

Gene expression profiles associated with pediatric relapsed AML. PLoS One (2015) 0.80

The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1. Biochim Biophys Acta (2011) 0.76

Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. Leukemia (2016) 1.45

Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis. Leukemia (2016) 0.77

Meis2 as a critical player in MN1-induced leukemia. Blood Cancer J (2017) 0.75

Epidemiological, genetic, and clinical characterization by age of newly diagnosed acute myeloid leukemia based on an academic population-based registry study (AMLSG BiO). Ann Hematol (2017) 0.75