Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.

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Published in J Allergy Clin Immunol on February 03, 2016

Authors

Timothy S C Hinks1, Tom Brown2, Laurie C K Lau3, Hitasha Rupani3, Clair Barber4, Scott Elliott2, Jon A Ward3, Junya Ono5, Shoichiro Ohta6, Kenji Izuhara7, Ratko Djukanović3, Ramesh J Kurukulaaratchy8, Anoop Chauhan2, Peter H Howarth3

Author Affiliations

1: Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom. Electronic address: t.hinks@soton.ac.uk.
2: Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom.
3: Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom.
4: NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom.
5: Shino-Test Corporation, Kanagawa, Japan.
6: Department of Laboratory Medicine, Saga Medical School, Saga, Japan.
7: Department of Biomolecular Sciences, Saga Medical School, Saga, Japan.
8: Department of Respiratory Medicine, Southampton General Hospital, Southampton, United Kingdom.

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