Published in Prog Brain Res on January 01, 1989
Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature (1998) 6.27
Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat Genet (1999) 4.74
Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease. Cell (1998) 4.41
Nicotinic receptors at the amino acid level. Annu Rev Pharmacol Toxicol (2000) 4.04
Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature (1991) 3.52
Use of a snake venom toxin to characterize the cholinergic receptor protein. Proc Natl Acad Sci U S A (1970) 3.48
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet (1999) 3.37
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature (1995) 3.28
A neuronal model of a global workspace in effortful cognitive tasks. Proc Natl Acad Sci U S A (1998) 3.25
Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs. Mol Pharmacol (1966) 3.17
On the nature of allosteric transitions: implications of non-exclusive ligand binding. J Mol Biol (1966) 3.11
Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci (2001) 3.05
Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature (1993) 2.99
Complete mRNA coding sequence of the acetylcholine binding alpha-subunit of Torpedo marmorata acetylcholine receptor: a model for the transmembrane organization of the polypeptide chain. Proc Natl Acad Sci U S A (1983) 2.98
Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks. Nature (1977) 2.95
Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature (1992) 2.88
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev (1999) 2.76
Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature (1993) 2.73
Acetylcholine receptor: an allosteric protein. Science (1984) 2.70
Large-scale purification of the acetylcholine-receptor protein in its membrane-bound and detergent-extracted forms from Torpedo marmorata electric organ. Eur J Biochem (1977) 2.59
Development of elementary numerical abilities: a neuronal model. J Cogn Neurosci (1993) 2.52
Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration. J Neurosci (2008) 2.52
The acetylcholine receptor: an "allosteric" membrane protein. Harvey Lect (1982) 2.42
Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia. Hum Mol Genet (2000) 2.40
Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor alpha-subunit gene. Nature (1990) 2.39
Requirement of the nicotinic acetylcholine receptor beta 2 subunit for the anatomical and functional development of the visual system. Proc Natl Acad Sci U S A (2001) 2.28
Structural and functional properties of the acetylcholine receptor protein in its purified and membrane-bound states. Annu Rev Biochem (1978) 2.19
Conductance increases produced by bath application of cholinergic agonists to Electrophorus electroplaques. J Gen Physiol (1975) 2.19
Identification of four classes of brain nicotinic receptors using beta2 mutant mice. J Neurosci (1998) 2.18
The primary periodic paralyses: diagnosis, pathogenesis and treatment. Brain (2005) 2.17
Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha 7 nicotinic receptor. Proc Natl Acad Sci U S A (1993) 2.14
Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature (1999) 2.13
Purification from Torpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor protein. FEBS Lett (1972) 2.09
Mutational analysis of the charge selectivity filter of the alpha7 nicotinic acetylcholine receptor. Neuron (1999) 2.08
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine. Proc Natl Acad Sci U S A (1986) 2.06
Differential role of nicotinic acetylcholine receptor subunits in physical and affective nicotine withdrawal signs. J Pharmacol Exp Ther (2008) 2.04
Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata. FEBS Lett (1973) 2.03
Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current. Proc Natl Acad Sci U S A (2000) 1.97
On the mode of action of colicins: a model of regulation at the membrane level. J Theor Biol (1967) 1.88
Functional architecture of the nicotinic acetylcholine receptor: from electric organ to brain. Annu Rev Pharmacol Toxicol (1991) 1.85
Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. Proc Natl Acad Sci U S A (1992) 1.84
Affinity labeling of the acetylcholine-receptor. Proc Natl Acad Sci U S A (1967) 1.83
Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein. Physiol Rev (1984) 1.83
Hypokalaemic periodic paralysis type 2 caused by mutations at codon 672 in the muscle sodium channel gene SCN4A. Brain (2001) 1.82
Detection of the nicotinic acetylcholine receptor alpha-subunit mRNA by in situ hybridization at neuromuscular junctions of 15-day-old chick striated muscles. EMBO J (1988) 1.81
Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry (1988) 1.80
Highly selective agonists for substance P receptor subtypes. EMBO J (1986) 1.80
Targeting transcription to the neuromuscular synapse. Neuron (2001) 1.79
Transmembrane orientation of proteins present in acetylcholine receptor-rich membranes from Torpedo marmorata studied by selective proteolysis. Eur J Biochem (1980) 1.79
Ivermectin: a positive allosteric effector of the alpha7 neuronal nicotinic acetylcholine receptor. Mol Pharmacol (1998) 1.78
Neuromyelitis optica in France: a multicenter study of 125 patients. Neurology (2010) 1.75
Activity regulates the levels of acetylcholine receptor alpha-subunit mRNA in cultured chicken myotubes. Proc Natl Acad Sci U S A (1985) 1.73
Allosteric interactions in aspartate transcarbamylase. I. Binding of specific ligands to the native enzyme and its isolated subunits. Biochemistry (1968) 1.71
Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin. Proc Natl Acad Sci U S A (1978) 1.71
On the excitability and cooperativity of the electroplax membrane. Proc Natl Acad Sci U S A (1968) 1.70
Calcium influx through nicotinic receptor in rat central neurons: its relevance to cellular regulation. Neuron (1992) 1.68
Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J Mol Evol (1995) 1.67
Nicotinic receptors in wonderland. Trends Biochem Sci (2001) 1.67
Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata. Proc Natl Acad Sci U S A (1975) 1.66
Golgi apparatus in chick skeletal muscle: changes in its distribution during end plate development and after denervation. Proc Natl Acad Sci U S A (1989) 1.66
The non-dystrophic myotonias: molecular pathogenesis, diagnosis and treatment. Brain (2009) 1.65
Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. Eur J Neurosci (1996) 1.65
Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from torpedo marmorata. Biochemistry (1983) 1.64
Differential activation of virulence gene expression by PrfA, the Listeria monocytogenes virulence regulator. J Bacteriol (1995) 1.64
Nicotinic receptor function: new perspectives from knockout mice. Trends Pharmacol Sci (2000) 1.64
[A theory of electric excitation of biological membranes]. C R Acad Sci Hebd Seances Acad Sci D (1970) 1.63
Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit. J Pharmacol Exp Ther (1999) 1.61
A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biol Cybern (1996) 1.61
A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form. J Cell Sci (1978) 1.59
Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). Nat Genet (2000) 1.58
A theory of the epigenesis of neuronal networks by selective stabilization of synapses. Proc Natl Acad Sci U S A (1973) 1.56
Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis. FEBS Lett (1991) 1.54
Potentiation of nicotinic receptor response by external calcium in rat central neurons. Neuron (1992) 1.54
Acetylcholine receptor gene expression at the developing neuromuscular junction. Physiol Rev (1995) 1.53
A 5'-flanking region of the chicken acetylcholine receptor alpha-subunit gene confers tissue specificity and developmental control of expression in transfected cells. Mol Cell Biol (1987) 1.52
Allosteric transitions of the acetylcholine receptor. Adv Protein Chem (1998) 1.50
Neuromyelitis optica and pregnancy. Neurology (2012) 1.49
Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes. Neurosci Lett (1986) 1.49
Consequences of tenotomy on the evolution of multiinnervation in developing rat soleus muscle. Brain Res (1975) 1.49
Linkage of a new locus for autosomal dominant familial spastic paraplegia to chromosome 2p. Hum Mol Genet (1994) 1.49
Ultraviolet light-induced labeling by noncompetitive blockers of the acetylcholine receptor from Torpedo marmorata. Proc Natl Acad Sci U S A (1981) 1.47
Progress in the purification of the cholinergic receptor protein from Electrophorus electricus by affinity chromatography. FEBS Lett (1972) 1.47
Immunosuppressive therapy is more effective than interferon in neuromyelitis optica. Mult Scler (2007) 1.45
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: [3H]chlorpromazine labels homologous residues in the beta and delta chains. Biochemistry (1987) 1.45
Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc Natl Acad Sci U S A (1985) 1.44
Human skeletal muscle sodium channelopathies. Neurol Sci (2005) 1.43
The noncompetitive blocker [3H]chlorpromazine labels three amino acids of the acetylcholine receptor gamma subunit: implications for the alpha-helical organization of regions MII and for the structure of the ion channel. Proc Natl Acad Sci U S A (1990) 1.43
Studies on the cholinergic receptor protein of Electrophorus electricus. I. An assay in vitro for the cholinergic receptor site and solubilization of the receptor protein from electric tissue. Mol Pharmacol (1971) 1.43
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes Immun (2008) 1.43
Some structural properties of the cholinergic receptor protein in its membrane environmental relevant to its function as a pharmacological receptor. Cold Spring Harb Symp Quant Biol (1976) 1.42
Hereditary thermosensitive neuropathy: an autosomal dominant disorder of the peripheral nervous system. Neurology (1997) 1.42
Binding of Naja nigricollis (3H)alpha-toxin to membrane fragments from Electrophorus and Torpedo electric organs. 3. Effects of local anaesthetics on the binding of the tritiated alpha-neurotoxin. Mol Pharmacol (1974) 1.41