Published in Pharmacol Rev on June 01, 1989
Systematic discovery of multicomponent therapeutics. Proc Natl Acad Sci U S A (2003) 3.86
Predicting selective drug targets in cancer through metabolic networks. Mol Syst Biol (2011) 3.65
Synergistic drug combinations tend to improve therapeutically relevant selectivity. Nat Biotechnol (2009) 3.49
Accelerated evolution of resistance in multidrug environments. Proc Natl Acad Sci U S A (2008) 2.45
TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. Antimicrob Agents Chemother (2009) 2.44
Chemical combination effects predict connectivity in biological systems. Mol Syst Biol (2007) 2.42
Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action. Environ Health Perspect (2002) 2.26
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel. Br J Cancer (2001) 2.14
Systematic exploration of synergistic drug pairs. Mol Syst Biol (2011) 1.89
In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates. Antimicrob Agents Chemother (2003) 1.85
Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol (2011) 1.81
Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci U S A (2004) 1.77
Prediction and assessment of the effects of mixtures of four xenoestrogens. Environ Health Perspect (2000) 1.74
Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci U S A (2012) 1.69
Interactions between drugs and occupied receptors. Pharmacol Ther (2006) 1.53
Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals. Environ Health Perspect (2007) 1.48
Comparison of methods for evaluating drug-drug interaction. Front Biosci (Elite Ed) (2010) 1.45
Spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test. Pain Res Manag (2015) 1.39
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine. Blood (2005) 1.38
Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli. J Clin Invest (1994) 1.34
Defining fractional inhibitory concentration index cutoffs for additive interactions based on self-drug additive combinations, Monte Carlo simulation analysis, and in vitro-in vivo correlation data for antifungal drug combinations against Aspergillus fumigatus. Antimicrob Agents Chemother (2009) 1.29
Synergistic interaction between cisplatin and taxol in human ovarian carcinoma cells in vitro. Br J Cancer (1994) 1.26
Optimal drug synergy in antimicrobial treatments. PLoS Comput Biol (2010) 1.23
Mixtures of four organochlorines enhance human breast cancer cell proliferation. Environ Health Perspect (2001) 1.22
In vivo efficacy of human immunodeficiency virus neutralizing antibodies: estimates for protective titers. J Virol (2007) 1.20
Revisiting the isobole and related quantitative methods for assessing drug synergism. J Pharmacol Exp Ther (2012) 1.20
Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor. Mol Cancer Ther (2008) 1.16
Counter-current chromatography based analysis of synergy in an anti-tuberculosis ethnobotanical. J Chromatogr A (2007) 1.14
Confidence Intervals of Interaction Index for Assessing Multiple Drug Interaction. Stat Biopharm Res (2009) 1.14
Reconceptualizing synergism and antagonism among multiple stressors. Ecol Evol (2015) 1.12
Use of pharmacodynamic indices to predict efficacy of combination therapy in vivo. Antimicrob Agents Chemother (1999) 1.11
Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Biochem J (1996) 1.10
In vitro interactions between tacrolimus and azoles against Candida albicans determined by different methods. Antimicrob Agents Chemother (2007) 1.09
Hindbrain leptin and glucagon-like-peptide-1 receptor signaling interact to suppress food intake in an additive manner. Int J Obes (Lond) (2012) 1.08
Analysis of drug combinations: current methodological landscape. Pharmacol Res Perspect (2015) 1.08
BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis. Mol Cancer Ther (2008) 1.07
A semiparametric response surface model for assessing drug interaction. Biometrics (2007) 1.07
The fractional maximal effect method: a new way to characterize the effect of antibiotic combinations and other nonlinear pharmacodynamic interactions. Antimicrob Agents Chemother (1993) 1.06
Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma. Virol J (2005) 1.04
Water contamination reduces the tolerance of coral larvae to thermal stress. PLoS One (2011) 1.03
Use of pharmacodynamic parameters to predict efficacy of combination therapy by using fractional inhibitory concentration kinetics. Antimicrob Agents Chemother (1998) 1.02
An enhanced Petri-net model to predict synergistic effects of pairwise drug combinations from gene microarray data. Bioinformatics (2011) 1.01
Synergistic anti-influenza virus A (H1N1) activities of PM-523 (polyoxometalate) and ribavirin in vitro and in vivo. Antimicrob Agents Chemother (1997) 1.01
Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro. Clin Cancer Res (2012) 1.01
In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir. Antimicrob Agents Chemother (2000) 1.01
Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro. Antimicrob Agents Chemother (2004) 1.00
Phytomedicine research in Germany. Environ Health Perspect (1999) 0.97
Analysis of the combined effect of two linear inhibitors on a single enzyme. Biochem J (1998) 0.97
Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis). J Nat Prod (2011) 0.97
Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Environ Health Perspect (2010) 0.96
Biguanide-atovaquone synergy against Plasmodium falciparum in vitro. Antimicrob Agents Chemother (2002) 0.96
Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children. Dev Psychopathol (2012) 0.95
Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrob Agents Chemother (2011) 0.94
Evaluating quantitative formulas for dose-response assessment of chemical mixtures. Environ Health Perspect (2002) 0.94
Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy. J Am Chem Soc (2010) 0.94
Contrasting theories of interaction in epidemiology and toxicology. Environ Health Perspect (2012) 0.94
Cytotoxic effects of histone deacetylase inhibitor FK228 (depsipeptide, formally named FR901228) in combination with conventional anti-leukemia/lymphoma agents against human leukemia/lymphoma cell lines. Invest New Drugs (2007) 0.93
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. PLoS One (2013) 0.93
At therapeutic concentration bupivacaine causes neuromuscular blockade and enhances rocuronium-induced blockade. Korean J Anesthesiol (2012) 0.93
What is synergy? The Saariselkä agreement revisited. Front Pharmacol (2015) 0.93
Searching for Drug Synergy in Complex Dose-Response Landscapes Using an Interaction Potency Model. Comput Struct Biotechnol J (2015) 0.93
Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83. PLoS One (2014) 0.91
Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer (2007) 0.91
Generalized concentration addition: a method for examining mixtures containing partial agonists. J Theor Biol (2009) 0.91
ras oncogene-dependent activation of the P4 promoter of minute virus of mice through a proximal P4 element interacting with the Ets family of transcription factors. J Virol (1996) 0.91
Drug interaction: focusing on response surface models. Korean J Anesthesiol (2010) 0.91
The antagonistic effect of neostigmine on rocuronium-, clindamycin-, or both-induced neuromuscular blocking in the rat phrenic nerve-hemidiaphragm. Korean J Anesthesiol (2011) 0.90
Emax model and interaction index for assessing drug interaction in combination studies. Front Biosci (Elite Ed) (2010) 0.89
Thermal potentiation of chemotherapy by magnetic nanoparticles. Nanomedicine (Lond) (2013) 0.89
A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula. Environ Health Perspect (2003) 0.89
Protein kinase Cbeta modulates ligand-induced cell surface death receptor accumulation: a mechanistic basis for enzastaurin-death ligand synergy. J Biol Chem (2009) 0.88
Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg (2008) 0.88
Mixture design and multivariate analysis in mixture research. Environ Health Perspect (1998) 0.88
Effects of neuropeptide Y and agonists selective for neuropeptide Y receptor sub-types on arterioles of the guinea-pig small intestine and the rat brain. Br J Pharmacol (1992) 0.88
Potent induction of antibody-secreting B cells by human dermal-derived CD14+ dendritic cells triggered by dual TLR ligation. J Immunol (2012) 0.88
In vitro interactions between amphotericin B, itraconazole, and flucytosine against 21 clinical Aspergillus isolates determined by two drug interaction models. Antimicrob Agents Chemother (2004) 0.88
Combination Drug Therapy for Pain following Chronic Spinal Cord Injury. Pain Res Treat (2012) 0.87
Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid. J Clin Invest (1997) 0.87
Propylene glycol produces excessive apoptosis in the developing mouse brain, alone and in combination with phenobarbital. Pediatr Res (2012) 0.87
Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.87
Isobolographic analysis of pharmacodynamic interactions between antifungal agents and ciprofloxacin against Candida albicans and Aspergillus fumigatus. Antimicrob Agents Chemother (2008) 0.86
Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation. J Nat Prod (2015) 0.86
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.85
Independent action between DvSnf7 RNA and Cry3Bb1 protein in southern corn rootworm, Diabrotica undecimpunctata howardi and Colorado potato beetle, Leptinotarsa decemlineata. PLoS One (2015) 0.85
Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics? BMC Neurol (2011) 0.85
Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling. PLoS One (2010) 0.85
NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning. PLoS Comput Biol (2016) 0.85
Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions. Neuro Oncol (2013) 0.84
Prediction of multidimensional drug dose responses based on measurements of drug pairs. Proc Natl Acad Sci U S A (2016) 0.84
Anti-hyperalgesic effects of imidazoline I2 receptor ligands in a rat model of inflammatory pain: interactions with oxycodone. Psychopharmacology (Berl) (2015) 0.84
Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.84
Antimicrobial combinations: Bliss independence and Loewe additivity derived from mechanistic multi-hit models. Philos Trans R Soc Lond B Biol Sci (2016) 0.84
Behavioral responses of the Iberian waterfrog, Pelophylax perezi (Seoane, 1885), to three nitrogenous compounds in laboratory conditions. Ecotoxicology (2011) 0.83
Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.83
Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis. Naunyn Schmiedebergs Arch Pharmacol (2006) 0.82
A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase. Sci Rep (2016) 0.82
Evaluation and modeling of synergy to pheromone and plant kairomone in American palm weevil. Chem Cent J (2011) 0.82
Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome. J Pharmacol Exp Ther (2013) 0.82
Synergy Maps: exploring compound combinations using network-based visualization. J Cheminform (2015) 0.82