Published in Drug Des Devel Ther on February 12, 2016
Fucoidans in Nanomedicine. Mar Drugs (2016) 0.75
Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial. Mar Drugs (2017) 0.75
Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways. Drug Des Devel Ther (2017) 0.75
TGFbeta signaling in growth control, cancer, and heritable disorders. Cell (2000) 12.38
Cytoplasmic components in hepatic cell lysosomes. J Cell Biol (1962) 6.57
Liver cirrhosis. Lancet (2008) 6.11
Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med (2006) 3.84
Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol (2011) 2.82
Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta (2013) 2.61
Activation of hepatic stellate cells--a key issue in liver fibrosis. Front Biosci (2002) 2.49
Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol (2012) 2.20
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology (2012) 2.11
Hepatic fibrosis -- overview. Toxicology (2008) 2.10
Mechanisms of liver fibrosis. Clin Chim Acta (2005) 2.09
Autophagy in human health and disease. N Engl J Med (2013) 2.04
The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology (2001) 1.88
Ethyl pyruvate ameliorates hepatic ischemia-reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy. Mediators Inflamm (2013) 1.80
Hepatic stellate cells and liver fibrosis. Compr Physiol (2013) 1.75
The global impact of hepatic fibrosis and end-stage liver disease. Clin Liver Dis (2008) 1.73
The crosstalk between autophagy and apoptosis: where does this lead? Protein Cell (2012) 1.60
Therapies from fucoidan; multifunctional marine polymers. Mar Drugs (2011) 1.34
Collagenase in experimental carbon tetrachloride cirrhosis of the liver. Am J Pathol (1978) 1.19
Fucoidan as a marine anticancer agent in preclinical development. Mar Drugs (2014) 1.14
Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer. Int J Biol Macromol (2013) 1.12
Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts. Cell Death Dis (2015) 1.07
Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis. World J Gastroenterol (2011) 1.06
Protective effect of astaxanthin on liver fibrosis through modulation of TGF-β1 expression and autophagy. Mediators Inflamm (2014) 1.05
Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis. J Vis Exp (2015) 1.04
N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway. PLoS One (2014) 1.03
Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression. PLoS One (2011) 1.00
Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction. Mol Med (2010) 0.97
Hydrogen sulfide, a potential novel drug, attenuates concanavalin A-induced hepatitis. Drug Des Devel Ther (2014) 0.95
Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis. PLoS One (2015) 0.92
Hydrogen sulfide ameliorates ischemia/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways. Mediators Inflamm (2014) 0.91
Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression. Autophagy (2014) 0.91
Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia-reperfusion injury in rats via regulating the inflammation response. Food Chem Toxicol (2011) 0.90
Autophagy: a new player in hepatic stellate cell activation. Autophagy (2012) 0.90
Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice. Mar Drugs (2015) 0.87
Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: a controversial issue. World J Gastroenterol (2014) 0.86
Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy. J Biol Chem (2015) 0.85
Autophagy: a housekeeper in cardiorenal metabolic health and disease. Biochim Biophys Acta (2014) 0.85
[Hepatic fibrosis: role of matrix metalloproteases and TGFbeta]. Gac Med Mex (2005) 0.84
Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress. Biosci Biotechnol Biochem (2011) 0.84
Fucoidan partly prevents CCl4-induced liver fibrosis. Eur J Pharmacol (2007) 0.84
[Effect of autophagy inhibitor 3-methyladenine on proliferation and activation of hepatic stellate cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2013) 0.82
Chloroquine improved carbon tetrachloride-induced liver fibrosis through its inhibition of the activation of hepatic stellate cells: role of autophagy. Biol Pharm Bull (2014) 0.82
Combination therapy of ursodeoxycholic acid and budesonide for PBC-AIH overlap syndrome: a meta-analysis. Drug Des Devel Ther (2015) 0.82
Low-molecular-weight fibroblast growth factor 2 attenuates hepatic fibrosis by epigenetic down-regulation of Delta-like1. Hepatology (2015) 0.82
Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts. Eur J Dermatol (2009) 0.82
Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis. Drug Des Devel Ther (2015) 0.82
A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis. J Gastroenterol (2015) 0.82
Strategies to prevent and reverse liver fibrosis in humans and laboratory animals. Arch Toxicol (2015) 0.79
Ghrelin reduces liver impairment in a model of concanavalin A-induced acute hepatitis in mice. Drug Des Devel Ther (2015) 0.79
Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis. Chin Med (2014) 0.78
The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis. PLoS One (2015) 0.78
Advanced glycation end product (AGE)-induced hepatic stellate cell activation via autophagy contributes to hepatitis C-related fibrosis. Acta Diabetol (2015) 0.78
Losartan alleviates renal fibrosis by down-regulating HIF-1α and up-regulating MMP-9/TIMP-1 in rats with 5/6 nephrectomy. Ren Fail (2012) 0.78
Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells. Mar Drugs (2015) 0.78
High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-β and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner. PLoS One (2014) 0.77
Liver fibrosis. Foreword. Semin Liver Dis (2015) 0.76
Combination therapy of fenofibrate and ursodeoxycholic acid in patients with primary biliary cirrhosis who respond incompletely to UDCA monotherapy: a meta-analysis. Drug Des Devel Ther (2015) 0.82
Combination therapy of ursodeoxycholic acid and budesonide for PBC-AIH overlap syndrome: a meta-analysis. Drug Des Devel Ther (2015) 0.82
Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3. Drug Des Devel Ther (2016) 0.79
Inhibitive effects of 15-deoxy-Δ(12),(14)-prostaglandin J2 on hepatoma-cell proliferation through reactive oxygen species-mediated apoptosis. Onco Targets Ther (2015) 0.76
Systematic review and meta-analysis: bezafibrate in patients with primary biliary cirrhosis. Drug Des Devel Ther (2015) 0.76