Published in RNA Biol on March 01, 2016
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression. Nature (2002) 8.14
Genetic control by a metabolite binding mRNA. Chem Biol (2002) 4.85
Sensing small molecules by nascent RNA: a mechanism to control transcription in bacteria. Cell (2002) 4.67
Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms. J Biol Chem (2002) 4.33
The structural and functional diversity of metabolite-binding riboswitches. Annu Rev Biochem (2009) 4.20
SAFA: semi-automated footprinting analysis software for high-throughput quantification of nucleic acid footprinting experiments. RNA (2005) 3.95
The distributions, mechanisms, and structures of metabolite-binding riboswitches. Genome Biol (2007) 3.80
The speed of RNA transcription and metabolite binding kinetics operate an FMN riboswitch. Mol Cell (2005) 3.62
Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals. Proc Natl Acad Sci U S A (2000) 3.59
A decade of riboswitches. Cell (2013) 3.26
Structure of the eukaryotic thiamine pyrophosphate riboswitch with its regulatory ligand. Science (2006) 3.24
The kinetics of ligand binding by an adenine-sensing riboswitch. Biochemistry (2005) 2.98
A conserved RNA structure (thi box) is involved in regulation of thiamin biosynthetic gene expression in bacteria. Proc Natl Acad Sci U S A (2001) 2.88
Crystal structures of the thi-box riboswitch bound to thiamine pyrophosphate analogs reveal adaptive RNA-small molecule recognition. Structure (2006) 2.85
The structural and biochemical foundations of thiamin biosynthesis. Annu Rev Biochem (2009) 2.32
Analyzing a kinetic titration series using affinity biosensors. Anal Biochem (2005) 2.27
Riboswitch control of gene expression in plants by splicing and alternative 3' end processing of mRNAs. Plant Cell (2007) 2.18
Riboswitches: small-molecule recognition by gene regulatory RNAs. Curr Opin Struct Biol (2007) 2.11
Adenosylcobalamin inhibits ribosome binding to btuB RNA. Proc Natl Acad Sci U S A (2000) 1.93
Ligand-induced folding of the thiM TPP riboswitch investigated by a structure-based fluorescence spectroscopic approach. Nucleic Acids Res (2007) 1.79
Riboswitches: structures and mechanisms. Cold Spring Harb Perspect Biol (2011) 1.75
Natural variability in S-adenosylmethionine (SAM)-dependent riboswitches: S-box elements in bacillus subtilis exhibit differential sensitivity to SAM In vivo and in vitro. J Bacteriol (2007) 1.73
Temperature-dependent regulation of flowering by antagonistic FLM variants. Nature (2013) 1.66
The flap domain is required for pause RNA hairpin inhibition of catalysis by RNA polymerase and can modulate intrinsic termination. Mol Cell (2003) 1.62
Folding of a large ribozyme during transcription and the effect of the elongation factor NusA. Proc Natl Acad Sci U S A (1999) 1.58
General plasmids for producing RNA in vitro transcripts with homogeneous ends. Nucleic Acids Res (2003) 1.56
Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs. Acc Chem Res (2011) 1.52
Thermodynamic analysis of ligand binding and ligand binding-induced tertiary structure formation by the thiamine pyrophosphate riboswitch. RNA (2009) 1.48
Riboswitch-dependent gene regulation and its evolution in the plant kingdom. Genes Dev (2007) 1.47
Design principles for riboswitch function. PLoS Comput Biol (2009) 1.44
Thiamine uptake in Escherichia coli. I. General properties of thiamine uptake system in Escherichia coli. Arch Biochem Biophys (1969) 1.39
Structural basis of thiamine pyrophosphate analogues binding to the eukaryotic riboswitch. J Am Chem Soc (2008) 1.36
Fast Fenton footprinting: a laboratory-based method for the time-resolved analysis of DNA, RNA and proteins. Nucleic Acids Res (2006) 1.33
A switch in time: detailing the life of a riboswitch. Biochim Biophys Acta (2009) 1.29
Semiautomated and rapid quantification of nucleic acid footprinting and structure mapping experiments. Nat Protoc (2008) 1.27
Vitamin B12 repression of the btuB gene in Salmonella typhimurium is mediated via a translational control which requires leader and coding sequences. Mol Microbiol (1997) 1.25
Biosynthesis of thiamine pyrophosphate in Escherichia coli. J Bacteriol (1972) 1.21
Conformational changes in the expression domain of the Escherichia coli thiM riboswitch. Nucleic Acids Res (2007) 1.17
C2'-endo nucleotides as molecular timers suggested by the folding of an RNA domain. Proc Natl Acad Sci U S A (2009) 1.16
Riboswitches: ancient and promising genetic regulators. Chembiochem (2009) 1.14
Molecular recognition and function of riboswitches. Curr Opin Struct Biol (2012) 1.13
Molecular basis of gene regulation by the THI-box riboswitch. Mol Microbiol (2007) 1.10
Folding and ligand recognition of the TPP riboswitch aptamer at single-molecule resolution. Proc Natl Acad Sci U S A (2013) 1.08
Folding energy landscape of the thiamine pyrophosphate riboswitch aptamer. Proc Natl Acad Sci U S A (2012) 1.07
Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch. Proc Natl Acad Sci U S A (2012) 1.07
kinITC: a new method for obtaining joint thermodynamic and kinetic data by isothermal titration calorimetry. J Am Chem Soc (2011) 1.02
Thiamine biosynthesis in Escherichia coli: in vitro reconstitution of the thiazole synthase activity. J Biol Chem (2004) 0.98
RNA folding during transcription: protocols and studies. Methods Enzymol (2009) 0.97
Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. Chem Biol (2014) 0.95
The role of E. coli Nus-factors in transcription regulation and transcription:translation coupling: From structure to mechanism. Transcription (2011) 0.91
A family of synthetic riboswitches adopts a kinetic trapping mechanism. Nucleic Acids Res (2014) 0.84
Characterization of the kinetic and thermodynamic landscape of RNA folding using a novel application of isothermal titration calorimetry. Nucleic Acids Res (2011) 0.83
Single-molecule conformational dynamics of a biologically functional hydroxocobalamin riboswitch. J Am Chem Soc (2014) 0.82
Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches. Biochem Soc Trans (2011) 0.81
Exhaustive Enumeration of Kinetic Model Topologies for the Analysis of Time-Resolved RNA Folding. Algorithms (2009) 0.79
Novel TPP-riboswitch activators bypass metabolic enzyme dependency. Front Chem (2014) 0.78