Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 26940098)

Published in J Am Soc Nephrol on March 03, 2016

Authors

Mahdi Salih1, Jeroen A Demmers2, Karel Bezstarosti2, Wouter N Leonhard3, Monique Losekoot4, Cees van Kooten5, Ron T Gansevoort6, Dorien J M Peters3, Robert Zietse1, Ewout J Hoorn7, DIPAK Consortium

Author Affiliations

1: Department of Internal Medicine, Division of Nephrology & Transplantation, and.
2: Proteomics Center, Erasmus Medical Center, Rotterdam, The Netherlands.
3: Departments of Human Genetics.
4: Clinical Genetics, and.
5: Nephrology, Leiden University Medical Center, Leiden, The Netherlands; and.
6: Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands.
7: Department of Internal Medicine, Division of Nephrology & Transplantation, and e.j.hoorn@erasmusmc.nl.

Articles cited by this

DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol (2003) 84.79

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol (2008) 38.00

ProteomeXchange provides globally coordinated proteomics data submission and dissemination. Nat Biotechnol (2014) 13.40

Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol (2006) 13.29

Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A (2004) 8.74

Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol (2008) 3.22

As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles (2013) 3.01

Overexpression of innate immune response genes in a model of recessive polycystic kidney disease. Kidney Int (2007) 2.64

Discovery of protein biomarkers for renal diseases. J Am Soc Nephrol (2004) 2.43

Cyst formation and growth in autosomal dominant polycystic kidney disease. Kidney Int (1987) 2.16

Characterization of PKD protein-positive exosome-like vesicles. J Am Soc Nephrol (2009) 2.13

Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers. Kidney Int (2012) 2.06

Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease. J Intern Med (2014) 2.06

Therapeutic potential of vasopressin V2 receptor antagonist in a mouse model for autosomal dominant polycystic kidney disease: optimal timing and dosing of the drug. Nephrol Dial Transplant (2011) 2.04

Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet (2007) 2.03

Software tool for researching annotations of proteins: open-source protein annotation software with data visualization. Anal Chem (2009) 1.68

Tamm-Horsfall protein and urinary exosome isolation. Kidney Int (2010) 1.61

Plakins: goliaths that link cell junctions and the cytoskeleton. Nat Rev Mol Cell Biol (2004) 1.60

Identification of gene mutations in autosomal dominant polycystic kidney disease through targeted resequencing. J Am Soc Nephrol (2012) 1.57

Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation. Kidney Int (2002) 1.56

Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. J Clin Invest (1999) 1.41

Exosomes and the kidney: prospects for diagnosis and therapy of renal diseases. Kidney Int (2011) 1.37

Urinary exosomes: a reservoir for biomarker discovery and potential mediators of intrarenal signalling. Proteomics (2013) 1.29

Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients. Proteomics Clin Appl (2008) 1.22

Autosomal dominant polycystic kidney disease: the changing face of clinical management. Lancet (2015) 1.21

Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J Immunol (1989) 1.21

Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells. Hum Mol Genet (2000) 1.20

Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model. Am J Physiol Renal Physiol (2011) 1.17

Combined proteomics and pathways analysis of collecting duct reveals a protein regulatory network activated in vasopressin escape. J Am Soc Nephrol (2005) 1.10

Urinary extracellular vesicles and the kidney: biomarkers and beyond. Am J Physiol Renal Physiol (2014) 1.09

Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. Nephrol Dial Transplant (2013) 1.08

Human urinary exosomes as innate immune effectors. J Am Soc Nephrol (2014) 1.07

Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients. J Intern Med (2014) 1.07

Quantitative comparison of the fasted and re-fed mouse liver phosphoproteomes using lower pH reductive dimethylation. Methods (2013) 1.07

Subfractionation, characterization, and in-depth proteomic analysis of glomerular membrane vesicles in human urine. Kidney Int (2013) 1.04

Aberrant epithelial cell growth in autosomal dominant polycystic kidney disease. Am J Kidney Dis (1991) 1.03

Polycystin-1 binds Par3/aPKC and controls convergent extension during renal tubular morphogenesis. Nat Commun (2013) 0.99

Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol (2013) 0.99

The phosphorylated sodium chloride cotransporter in urinary exosomes is superior to prostasin as a marker for aldosteronism. Hypertension (2012) 0.97

Interaction of phospholipase C-gamma1 with villin regulates epithelial cell migration. J Biol Chem (2006) 0.96

Identification of Biomarkers for PKD1 Using Urinary Exosomes. J Am Soc Nephrol (2014) 0.96

Application of systems biology principles to protein biomarker discovery: urinary exosomal proteome in renal transplantation. Proteomics Clin Appl (2012) 0.93

Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease. Am J Physiol Renal Physiol (2005) 0.91

The classical complement pathway plays a critical role in the opsonisation of uropathogenic Escherichia coli. Mol Immunol (2007) 0.90

Rationale and design of the DIPAK 1 study: a randomized controlled clinical trial assessing the efficacy of lanreotide to Halt disease progression in autosomal dominant polycystic kidney disease. Am J Kidney Dis (2013) 0.84

Role of obstruction in autosomal dominant polycystic kidney disease in rats. Kidney Int (1996) 0.84

The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid. Proteomics Clin Appl (2009) 0.82

Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome. J Immunol (2015) 0.80

Regulation of the microtubular cytoskeleton by Polycystin-1 favors focal adhesions turnover to modulate cell adhesion and migration. BMC Cell Biol (2015) 0.79

Functional assessment of mouse complement pathway activities and quantification of C3b/C3c/iC3b in an experimental model of mouse renal ischaemia/reperfusion injury. J Immunol Methods (2015) 0.79

Is there a role for locally produced complement in renal disease? Nephrol Dial Transplant (2000) 0.78