Published in Curr Diab Rep on May 01, 2016
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47
Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol (2004) 17.54
Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell (2004) 5.59
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat Med (2009) 5.54
Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5.29
Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science (1993) 5.22
Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity (1999) 4.61
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet (2011) 4.30
Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA (2007) 4.29
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet (2007) 4.22
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell (1990) 4.15
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial. Lancet (2011) 4.15
Revving the engine: signal transduction fuels T cell activation. Immunity (2007) 3.57
Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol (2007) 3.53
IL-7 enhances the survival and maintains the size of naive T cells. J Immunol (2001) 3.39
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet (2011) 3.13
Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell (1997) 3.13
Unravelling cancer stem cell potential. Nat Rev Cancer (2013) 3.06
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors. Blood (2012) 3.02
Normalization of CD4+ T cell metabolism reverses lupus. Sci Transl Med (2015) 2.70
Metabolic checkpoints in activated T cells. Nat Immunol (2012) 2.47
Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol (2007) 2.28
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood (2007) 2.24
Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev (2004) 2.18
Superior T memory stem cell persistence supports long-lived T cell memory. J Clin Invest (2013) 2.06
Metabolism in T cell activation and differentiation. Curr Opin Immunol (2010) 1.97
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest (2002) 1.95
Rapid turnover of effector-memory CD4(+) T cells in healthy humans. J Exp Med (2004) 1.85
Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J Exp Med (2004) 1.83
The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure. Diabetologia (2003) 1.73
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest (2008) 1.73
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool. Proc Natl Acad Sci U S A (2008) 1.62
Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease. Sci Transl Med (2011) 1.61
A causal link between lymphopenia and autoimmunity. Immunol Lett (2004) 1.61
Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci U S A (2012) 1.60
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A (2012) 1.54
Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J Immunol (2007) 1.49
CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity. Proc Natl Acad Sci U S A (2008) 1.48
IL-7 promotes T cell proliferation through destabilization of p27Kip1. J Exp Med (2006) 1.40
Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients. Diabetes (1999) 1.38
Lineage relationship of effector and memory T cells. Curr Opin Immunol (2013) 1.30
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects. J Autoimmun (2005) 1.28
Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis. Eur J Hum Genet (2003) 1.23
Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol (2005) 1.15
Recurrence of autoreactive antigen-specific CD4+ T cells in autoimmune diabetes after pancreas transplantation. Clin Immunol (2008) 1.14
Visualization and identification of IL-7 producing cells in reporter mice. PLoS One (2009) 1.11
IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells. J Immunol (2012) 0.98
Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes. Clin Exp Immunol (2010) 0.92
Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene. Am J Physiol Cell Physiol (2010) 0.92
Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes Immun (2007) 0.91
Recent progress and perspective in JAK inhibitors for rheumatoid arthritis: from bench to bedside. J Biochem (2015) 0.89
Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus. Curr Diab Rep (2009) 0.89
Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradation. J Immunol (2010) 0.86
Disengaging the IL-2 receptor with daclizumab enhances IL-7-mediated proliferation of CD4(+) and CD8(+) T cells. Am J Transplant (2009) 0.84
Concentration and activity of the soluble form of the interleukin-7 receptor α in type 1 diabetes identifies an interplay between hyperglycemia and immune function. Diabetes (2013) 0.83
Activation of islet autoreactive naïve T cells in infants is influenced by homeostatic mechanisms and antigen-presenting capacity. Diabetes (2013) 0.83
IL-7 receptor blockade following T cell depletion promotes long-term allograft survival. J Clin Invest (2014) 0.81
Risks, benefits, and therapeutic potential of hematopoietic stem cell transplantation for autoimmune diabetes. Curr Diab Rep (2012) 0.80
Interleukin-7 and type 1 diabetes. Curr Diab Rep (2014) 0.76