Published in Cancer Cell Int on April 01, 2016
Global cancer statistics. CA Cancer J Clin (2011) 185.92
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Cancer statistics, 2012. CA Cancer J Clin (2012) 87.38
Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA (2014) 36.94
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 35.39
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA (2012) 33.54
Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA (2006) 24.01
Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet (2003) 18.24
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol (2007) 10.49
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science (1995) 7.87
Epidemiology of basal-like breast cancer. Breast Cancer Res Treat (2007) 7.08
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors. Nat Biotechnol (2007) 6.56
Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst (2006) 6.41
Breast cancer statistics, 2011. CA Cancer J Clin (2011) 6.12
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med (2011) 5.54
Diabetes, obesity, and the brain. Science (2005) 4.59
Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev (2007) 4.23
Effect of obesity on prognosis after early-stage breast cancer. J Clin Oncol (2010) 3.92
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell (2012) 3.77
Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65
Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials. JAMA Oncol (2015) 3.64
Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem (1997) 3.01
Applying what we know to accelerate cancer prevention. Sci Transl Med (2012) 2.43
Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol (2014) 2.35
The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma. Oncogene (2000) 2.15
The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev (2012) 2.01
Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring) (2011) 1.90
The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat (2012) 1.77
Leptin signaling in breast cancer: an overview. J Cell Biochem (2008) 1.71
Prognostic value of body mass index in locally advanced breast cancer. Clin Cancer Res (2008) 1.49
High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer (2006) 1.43
PKCalpha expression is a marker for breast cancer aggressiveness. Mol Cancer (2010) 1.34
Energy restriction and the risk of spontaneous mammary tumors in mice: a meta-analysis. Int J Cancer (2003) 1.30
Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One (2012) 1.27
Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies. Mol Endocrinol (2010) 1.24
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet (2013) 1.23
Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst (2014) 1.22
Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of function. J Biol Chem (2010) 1.18
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun (2015) 1.14
Targeting AMPK for cancer prevention and treatment. Oncotarget (2015) 1.13
Definition of PKC-α, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res (2014) 1.09
Obesity, metabolism and the microenvironment: Links to cancer. J Carcinog (2013) 1.07
Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocr Relat Cancer (2013) 1.06
Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. Breast Cancer Res (2013) 1.03
Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients. Breast Cancer Res (2012) 1.03
Dietary energy balance modulates epithelial-to-mesenchymal transition and tumor progression in murine claudin-low and basal-like mammary tumor models. Cancer Prev Res (Phila) (2012) 1.01
PKA signaling drives mammary tumorigenesis through Src. Oncogene (2014) 0.99
Application of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemia. PLoS One (2013) 0.99
Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF-7 human breast cancer cells through a MEK/ERK-dependent signaling pathway. Exp Cell Res (2012) 0.94
The Association between Leptin Level and Breast Cancer: A Meta-Analysis. PLoS One (2013) 0.94
Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life. Front Physiol (2012) 0.94
Body mass index at early adulthood, subsequent weight change and cancer incidence and mortality. Int J Cancer (2014) 0.92
The anti-diabetic drug metformin suppresses the metastasis-associated protein CD24 in MDA-MB-468 triple-negative breast cancer cells. Oncol Rep (2011) 0.90
Effect of moderate caloric restriction and/or weight cycling on mammary tumor incidence and latency in MMTV-Neu female mice. Nutr Cancer (2002) 0.89
A sustained increase in plasma NEFA upregulates the Toll-like receptor network in human muscle. Diabetologia (2013) 0.88
Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice. Diabetologia (2008) 0.88
Adaptive reprogramming of the breast cancer kinome. Clin Pharmacol Ther (2014) 0.88
Targeting MKK3 as a novel anticancer strategy: molecular mechanisms and therapeutical implications. Cell Death Dis (2015) 0.87
Weight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression. Front Oncol (2014) 0.87
Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer. Breast Cancer Res Treat (2013) 0.87
Pubertal high fat diet: effects on mammary cancer development. Breast Cancer Res (2013) 0.87
Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth. Int J Oncol (2011) 0.85
MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation. Hum Mol Genet (2013) 0.85
Long-term use of metformin and the molecular subtype in invasive breast carcinoma patients - a retrospective study of clinical and tumor characteristics. BMC Cancer (2014) 0.84
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. Curr Breast Cancer Rep (2014) 0.83
Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. Am J Physiol Endocrinol Metab (2008) 0.82
Breast cancer and hormone-replacement therapy: the Million Women Study. Lancet (2003) 0.81
Increased IL-6 detection in adult and pediatric lymphoid tissue harboring parvovirus B19. J Clin Virol (2013) 0.80
FAM123A binds to microtubules and inhibits the guanine nucleotide exchange factor ARHGEF2 to decrease actomyosin contractility. Sci Signal (2012) 0.80
Adult weight gain and central obesity in women with and without a family history of breast cancer: a case control study. Fam Cancer (2007) 0.80
Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice. PLoS One (2014) 0.78
Is there a link between a high-fat diet during puberty and breast cancer risk? Womens Health (Lond Engl) (2011) 0.78
Puberty-specific promotion of mammary tumorigenesis by a high animal fat diet. Breast Cancer Res (2015) 0.77
The Million Women Study and breast cancer. J Br Menopause Soc (2003) 0.76