IL-6 and IL-17A degradation by mast cells is mediated by a serglycin:serine protease axis.

Multi-omics analysis of serum samples demonstrates reprogramming of organ functions via systemic calcium mobilization and platelet activation in metastatic melanoma. Mol Cell Proteomics (2016) 0.75

Mast cells in the development of adaptive immune responses. Nat Immunol (2005) 4.96

IL-6: regulator of Treg/Th17 balance. Eur J Immunol (2010) 3.82

New developments in mast cell biology. Nat Immunol (2008) 3.72

Mast-cell responses to pathogens. Nat Rev Immunol (2004) 3.26

Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology (2009) 2.92

Mast cells can enhance resistance to snake and honeybee venoms. Science (2006) 2.72

Mast cells express IL-17A in rheumatoid arthritis synovium. J Immunol (2010) 2.64

Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis. J Immunol (2011) 2.53

IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin Sci (Lond) (2012) 2.41

The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets (2007) 2.17

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase. J Exp Med (1991) 1.79

Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest (2004) 1.75

Mast cell proteases. Adv Immunol (2007) 1.70

Mast cell secretory granules: armed for battle. Nat Rev Immunol (2014) 1.53

Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing. J Immunol (2008) 1.48

Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation (2009) 1.43

Proteolytic activation of alternative CCR1 ligands in inflammation. J Immunol (2005) 1.32

Serglycin is essential for maturation of mast cell secretory granule. J Biol Chem (2004) 1.32

Peritoneal cell-derived mast cells: an in vitro model of mature serosal-type mouse mast cells. J Immunol (2007) 1.30

Cytokine production by skin-derived mast cells: endogenous proteases are responsible for degradation of cytokines. J Immunol (2005) 1.28

Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis. Immunology (2014) 1.25

Activation of paracrine TGF-beta1 signaling upon stimulation and degranulation of rat serosal mast cells: a novel function for chymase. FASEB J (2001) 1.22

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest (2011) 1.16

Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation. J Immunol (2009) 1.15

Serglycin: a structural and functional chameleon with wide impact on immune cells. J Immunol (2011) 1.11

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc Natl Acad Sci U S A (2014) 1.02

Interleukin 6 and rheumatoid arthritis. Biomed Res Int (2014) 1.00

Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem (2013) 0.97

The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol (2010) 0.95

Serglycin proteoglycan: regulating the storage and activities of hematopoietic proteases. Biofactors (2009) 0.93

The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol (2012) 0.92

Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5. Biol Chem (2003) 0.90

Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation. Mucosal Immunol (2012) 0.87

Mast cell granules potentiate endotoxin-induced interleukin-6 production by endothelial cells. J Leukoc Biol (1997) 0.86

Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem (2011) 0.86

Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G. Blood (2005) 0.86

Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4. Neurobiol Dis (2013) 0.85

Age-related enlargement of lymphoid tissue and altered leukocyte composition in serglycin-deficient mice. J Leukoc Biol (2008) 0.83

Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism. J Immunol (2014) 0.82

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis. Biol Chem (2012) 0.81

Human mast cells (HMC-1 5C6) enhance interleukin-6 production by quiescent and lipopolysaccharide-stimulated human coronary artery endothelial cells. Mediators Inflamm (2012) 0.78

Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction. Kidney Int (2013) 0.78