TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.

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Published in Cell Stem Cell on March 24, 2016

Authors

Haojian Zhang1, David E Kozono1, Kevin W O'Connor1, Sofia Vidal-Cardenas1, Alix Rousseau2, Abigail Hamilton1, Lisa Moreau1, Emily F Gaudiano1, Joel Greenberger3, Grover Bagby4, Jean Soulier2, Markus Grompe4, Kalindi Parmar1, Alan D D'Andrea5

Author Affiliations

1: Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
2: Institute of Hematology (IUH), University Paris-Diderot, 75010 Paris, France.
3: Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
4: Oregon Health and Science University, Portland, OR 97239, USA.
5: Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: alan_dandrea@dfci.harvard.edu.

Associated clinical trials:

Intra-patient Dose Escalation Study to Investigate Safety and Feasibility of Vactosertib in Treating Anemic MPN Patients | NCT04103645

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