Published in Cell Mol Life Sci on April 11, 2016
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A (2017) 0.77
Gasdermins: Effectors of Pyroptosis. Trends Cell Biol (2017) 0.75
Cryopyrin activates the inflammasome in response to toxins and ATP. Nature (2006) 18.74
Glutathione. Annu Rev Biochem (1983) 15.18
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature (2009) 12.58
Pyroptosis: host cell death and inflammation. Nat Rev Microbiol (2009) 7.63
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell (2012) 6.31
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun (2005) 6.31
Mechanisms by which mitochondria transport calcium. Am J Physiol (1990) 6.06
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol (2010) 6.05
Mechanisms and functions of inflammasomes. Cell (2014) 3.75
Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol (2006) 3.44
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature (2012) 3.40
Salmonella induces macrophage death by caspase-1-dependent necrosis. Mol Microbiol (2000) 3.34
Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer (2013) 3.23
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell (2012) 3.22
Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature (2012) 3.01
Parenteral iron formulations: a comparative toxicologic analysis and mechanisms of cell injury. Am J Kidney Dis (2002) 2.89
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci U S A (2008) 2.82
P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol (2008) 2.72
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature (2015) 2.71
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature (2015) 2.67
Strychnine binding associated with glycine receptors of the central nervous system. Proc Natl Acad Sci U S A (1973) 2.37
Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry (1999) 2.36
Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med Biol (2010) 1.86
A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem (1989) 1.82
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells. Cell Rep (2014) 1.82
Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene (1998) 1.81
Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates. Proc Natl Acad Sci U S A (2000) 1.74
Neuronal and glial glycine transporters have different stoichiometries. Neuron (2000) 1.72
Action of cyclosporine on mitochondrial calcium fluxes. J Bioenerg Biomembr (1987) 1.69
Glycine transporters: essential regulators of neurotransmission. Trends Biochem Sci (2005) 1.68
Attenuation of CCl(4)-induced hepatic fibrosis by GdCl(3) treatment or dietary glycine. Am J Physiol Gastrointest Liver Physiol (2001) 1.64
Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A (2014) 1.62
Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes. J Am Soc Nephrol (2015) 1.59
Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death. Involvement of serine but not cysteine proteases. Am J Pathol (1997) 1.58
Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes. Am J Physiol (1997) 1.58
The cell biology of ischemic renal injury. Kidney Int (1991) 1.54
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc (2014) 1.49
Glycine--an important neurotransmitter and cytoprotective agent. Acta Anaesthesiol Scand (2005) 1.47
The distribution of glycine in cat spinal cord and roots. Life Sci (1965) 1.45
Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care (2010) 1.44
Infusion of glycine does not attenuate in vivo ischemic acute renal failure in the rat. J Lab Clin Med (1993) 1.40
Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids (2013) 1.36
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Physiol Rev (2015) 1.31
Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene (1998) 1.29
Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubules. J Clin Invest (1987) 1.25
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature (2015) 1.22
Molecular pharmacology of the glycine receptor chloride channel. Curr Pharm Des (2007) 1.21
The metabolic response to ingested glycine. Am J Clin Nutr (2002) 1.19
Dietary glycine prevents chemical-induced experimental colitis in the rat. Gastroenterology (2003) 1.18
L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care (2003) 1.16
Candida albicans triggers NLRP3-mediated pyroptosis in macrophages. Eukaryot Cell (2013) 1.15
Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury. Am J Physiol Renal Physiol (2000) 1.14
Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol (2005) 1.14
Bordetella type III secretion induces caspase 1-independent necrosis. Cell Microbiol (2003) 1.12
Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death. Am J Physiol Renal Physiol (2007) 1.12
Transport of alpha-helical peptides through alpha-hemolysin and aerolysin pores. Biochemistry (2006) 1.10
Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack. Kidney Int (2000) 1.09
Dietary requirements of "nutritionally non-essential amino acids" by animals and humans. Amino Acids (2012) 1.09
Streptococcus pyogenes induces oncosis in macrophages through the activation of an inflammatory programmed cell death pathway. Cell Microbiol (2008) 1.08
Toll-like receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury. Am J Physiol Renal Physiol (2006) 1.08
Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis (1999) 1.05
Iron, heme oxygenase, and glutathione: effects on myohemoglobinuric proximal tubular injury. Kidney Int (1995) 1.05
Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site. Proc Natl Acad Sci U S A (1992) 1.05
Oxygen deprivation-induced injury to isolated rabbit kidney tubules. J Clin Invest (1985) 1.04
Intracellular glutathione in the protection from anoxic injury in renal proximal tubules. J Clin Invest (1990) 1.04
A diet containing glycine improves survival in endotoxin shock in the rat. Am J Physiol (1996) 1.03
Kupffer cells contain a glycine-gated chloride channel. Am J Physiol (1997) 1.03
Molecular evidence for a glycine-gated chloride channel in macrophages and leukocytes. Am J Physiol Gastrointest Liver Physiol (2002) 1.02
Structure and function of the glycine receptor and related nicotinicoid receptors. J Biol Chem (2004) 1.02
Kinetic determinants of agonist action at the recombinant human glycine receptor. J Physiol (2003) 1.02
Active ion transport in the renal proximal tubule. III. The ATP dependence of the Na pump. J Gen Physiol (1984) 1.02
Production of superoxide and TNF-alpha from alveolar macrophages is blunted by glycine. Am J Physiol (1999) 1.01
What confers specificity on glycine for its receptor site? Br J Pharmacol (1989) 1.01
Development of porous defects in plasma membranes of adenosine triphosphate-depleted Madin-Darby canine kidney cells and its inhibition by glycine. Lab Invest (1998) 1.00
A comparison of the effect of 1.5% glycine and 5% glucose irrigants on plasma serum physiology and the incidence of transurethral resection syndrome during prostate resection. BJU Int (2005) 1.00
Glycine-protected, hypoxic, proximal tubules develop severely compromised energetic function. Kidney Int (1997) 0.99
Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury. Free Radic Biol Med (2014) 0.98
Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am J Physiol Regul Integr Comp Physiol (2004) 0.98
Protection by glycine against hypoxic injury of rat hepatocytes: inhibition of ion fluxes through nonspecific leaks. J Hepatol (2000) 0.98
Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages. Mol Pharmacol (2004) 0.98
Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells. Hepatology (1999) 0.97
Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther (2015) 0.97
Glycine: a new anti-inflammatory immunonutrient. Cell Mol Life Sci (1999) 0.97
Glycine-gated chloride channels in neutrophils attenuate calcium influx and superoxide production. FASEB J (2000) 0.97
Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis (2000) 0.97
Accumulation of nonesterified fatty acids causes the sustained energetic deficit in kidney proximal tubules after hypoxia-reoxygenation. Am J Physiol Renal Physiol (2005) 0.96
Glycine attenuates Fanconi syndrome induced by maleate or ifosfamide in rats. Kidney Int (1996) 0.96
Glycine blocks opening of a death channel in cultured hepatic sinusoidal endothelial cells during chemical hypoxia. Cell Death Differ (2001) 0.95
Metabolic aspects of protection by glycine against hypoxic injury to isolated proximal tubules. J Am Soc Nephrol (1991) 0.95
Evidence for role of cytosolic free calcium in hypoxia-induced proximal tubule injury. J Clin Invest (1994) 0.95
Role of increased cytosolic free calcium in the pathogenesis of rabbit proximal tubule cell injury and protection by glycine or acidosis. J Clin Invest (1991) 0.95
Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration. Am J Physiol Renal Physiol (2009) 0.94
TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1. J Clin Invest (2014) 0.93
Sodium, phosphate, glucose, bicarbonate, and alanine interactions in the isolated proximal convoluted tubule of the rabbit kidney. J Clin Invest (1978) 0.93
Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo. Am J Physiol Renal Physiol (2002) 0.93
Ouabain-induced lethal proximal tubule cell injury is prevented by glycine. Am J Physiol (1990) 0.93
Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition. J Physiol (2004) 0.93
Glycine protection against hypoxic but not phospholipase A2-induced injury in rat proximal tubules. Am J Physiol (1993) 0.93
Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion. Gastroenterology (1992) 0.93