Libertas: a phase II placebo-controlled study of NRL001 in patients with faecal incontinence showed an unexpected and sustained placebo response.

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Published in Int J Colorectal Dis on April 13, 2016

Authors

L Siproudhis1, W Graf2, A Emmanuel3, D Walker4, R Ng Kwet Shing5, C Pediconi5, J Pilot5, S Wexner6, J Scholefield7

Author Affiliations

1: CHU Pontchaillou, Rennes, France.
2: Institution of Surgical Sciences, Akademiska Sjukhuset, Uppsala University, 75185, Uppsala, Sweden.
3: University College Hospital, 235 Euston Road, London, UK.
4: Norgine Ltd, Norgine House, Widewater Place, Moorhall Road, Uxbridge, UB9 6NS, UK. dwalker@norgine.com.
5: Norgine Ltd, Norgine House, Widewater Place, Moorhall Road, Uxbridge, UB9 6NS, UK.
6: Cleveland Clinic Florida, Weston, FL, USA.
7: Division of Surgery, University Hospital Nottingham, Nottingham, UK.

Associated clinical trials:

A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period | NCT01656720

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