Published in Am J Physiol Endocrinol Metab on April 19, 2016
The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism. Nutrients (2016) 0.81
Tryptophan Predicts the Risk for Future Type 2 Diabetes. PLoS One (2016) 0.77
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
Plasma amino acid levels and insulin secretion in obesity. N Engl J Med (1969) 4.18
Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet (1996) 3.35
Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab (2012) 3.26
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med (2011) 3.20
alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One (2010) 2.94
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One (2010) 2.84
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes (2012) 2.62
Loss of insulin resistance after Roux-en-Y gastric bypass surgery: a time course study. Obes Surg (2005) 2.59
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab (2007) 2.46
Novel biomarkers for pre-diabetes identified by metabolomics. Mol Syst Biol (2012) 2.39
SetupX--a public study design database for metabolomic projects. Pac Symp Biocomput (2007) 2.20
2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest (2013) 2.15
Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One (2010) 2.14
Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state. Adv Nutr (2011) 2.01
Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss. Diabetologia (2011) 1.93
Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci U S A (2009) 1.75
Branched-chain amino acids in metabolic signalling and insulin resistance. Nat Rev Endocrinol (2014) 1.71
Early metabolic markers of the development of dysglycemia and type 2 diabetes and their physiological significance. Diabetes (2012) 1.63
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab (2013) 1.58
Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care (2012) 1.57
Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach. Diabetes (2013) 1.44
Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans. Diabetes (2014) 1.42
Development and characterization of a novel rat model of type 2 diabetes mellitus: the UC Davis type 2 diabetes mellitus UCD-T2DM rat. Am J Physiol Regul Integr Comp Physiol (2008) 1.41
Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol (2004) 1.29
Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use. Am J Med (2009) 1.19
A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat. Diabetes (2001) 1.12
Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers. J Proteome Res (2009) 1.10
Metabolic profiling in diabetes. J Endocrinol (2014) 1.09
Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. PLoS One (2014) 1.09
Leucine and protein metabolism in obese Zucker rats. PLoS One (2013) 1.07
Increased plasma citrulline in mice marks diet-induced obesity and may predict the development of the metabolic syndrome. PLoS One (2013) 0.98
Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system. Anal Chim Acta (2009) 0.98
Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. Metabolism (2013) 0.97
Serum and adipose tissue amino acid homeostasis in the metabolically healthy obese. J Proteome Res (2014) 0.94
Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. Biochem Biophys Res Commun (2010) 0.93
1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control. J Clin Endocrinol Metab (2014) 0.91
Effect of insulin sensitizer therapy on amino acids and their metabolites. Metabolism (2015) 0.87
alpha-Ketoacid dehydrogenase complexes and respiratory fuel utilisation in diabetes. Diabetologia (1985) 0.82
Nutritional and hormonal regulation of the activity state of hepatic branched-chain alpha-keto acid dehydrogenase complex. Ann N Y Acad Sci (1989) 0.80
Simultaneous insulinlike growth factor I and insulin resistance in obese Zucker rats. Diabetes (1992) 0.79
Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A (1984) 0.78
The equivocal metabolic response to endotoxaemia in type 2 diabetic and obese ZDF rats. Diabetologia (2006) 0.78
Effect of metformin therapy on circulating amino acids in a randomized trial: the CAMERA study. Diabet Med (2016) 0.78
The Effects of Sleeve Gastrectomy and Gastric Bypass on Branched-Chain Amino Acid Metabolism 1 Year After Bariatric Surgery. Obes Surg (2016) 0.77