Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer's disease: a meta-analysis study (N=7277).

PubWeight™: 0.84‹?›

🔗 View Article (PMID 27113997)

Published in Mol Psychiatry on April 26, 2016

Authors

X-Y Qin1, C Cao1, N X Cawley2, T-T Liu1, J Yuan1, Y P Loh2, Y Cheng2

Author Affiliations

1: Section on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing, China.
2: Section on Cellular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Articles cited by this

(truncated to the top 100)

Bias in meta-analysis detected by a simple, graphical test. BMJ (1997) 122.24

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol (2007) 17.69

Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol (2009) 11.80

Quantitative synthesis in systematic reviews. Ann Intern Med (1997) 11.72

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci (2007) 7.96

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med (2007) 6.80

Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group. Neurobiol Aging (1998) 5.05

Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol (2010) 4.78

2015 Alzheimer's disease facts and figures. Alzheimers Dement (2015) 4.57

Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study. JAMA Neurol (2014) 3.04

Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology (1998) 2.89

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron (1991) 2.46

New insights in the biology of BDNF synthesis and release: implications in CNS function. J Neurosci (2009) 2.40

Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem (2005) 2.36

Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost (2002) 2.16

Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res Mol Brain Res (1997) 2.08

A meta-analysis of cytokines in Alzheimer's disease. Biol Psychiatry (2010) 2.06

The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc (2007) 2.00

Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ (2005) 1.95

Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology (2007) 1.91

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci (2013) 1.91

Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm (Vienna) (2005) 1.85

BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study. Neurobiol Learn Mem (2008) 1.68

Quantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Q statistics. BMC Med Res Methodol (2011) 1.66

Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484). Mol Psychiatry (2013) 1.66

Brain amyloid-β oligomers in ageing and Alzheimer's disease. Brain (2013) 1.64

Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain Res Mol Brain Res (2000) 1.53

Predictive accuracy of amyloid imaging for progression from mild cognitive impairment to Alzheimer disease with different lengths of follow-up: a meta-analysis. [Corrected]. Medicine (Baltimore) (2014) 1.50

Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies. Transl Psychiatry (2015) 1.49

BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies. J Neuropathol Exp Neurol (1999) 1.46

BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res (2006) 1.46

Oxidative stress and the pathogenesis of Alzheimer's disease. Oxid Med Cell Longev (2013) 1.44

Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease. Neurobiol Aging (2009) 1.40

Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiol Dis (2008) 1.39

Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data. Brain Res Bull (2007) 1.35

miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol (2012) 1.32

Alzheimer's disease and the amyloid cascade hypothesis: a critical review. Int J Alzheimers Dis (2012) 1.31

Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels. Ann N Y Acad Sci (2009) 1.24

Serum BDNF, TNF-alpha and IL-1beta levels in dementia patients: comparison between Alzheimer's disease and vascular dementia. Eur Arch Psychiatry Clin Neurosci (2006) 1.24

Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. Int J Neuropsychopharmacol (2010) 1.21

Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modulating local inflammation in rats. Neuroscience (2010) 1.18

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis. Mol Psychiatry (2014) 1.17

An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease. Neuroscience (1999) 1.17

Depression in dementia: epidemiology, mechanisms, and treatment. Curr Opin Psychiatry (2011) 1.17

Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults. J Geriatr Psychiatry Neurol (2008) 1.16

Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry (2009) 1.15

Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World J Biol Psychiatry (2010) 1.12

Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. J Clin Psychiatry (2008) 1.12

Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci (2007) 1.11

A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One (2013) 1.10

Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease. PLoS One (2012) 1.09

Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's disease. J Alzheimers Dis (2009) 1.06

Decreased peripheral brain-derived neurotrophic factor levels are a biomarker of disease activity in major psychiatric disorders: a comparative meta-analysis. Mol Psychiatry (2013) 1.05

Serum brain-derived neurotrophic factor levels are specifically associated with memory performance among Alzheimer's disease cases. Dement Geriatr Cogn Disord (2010) 1.04

Decreased serum brain-derived neurotrophic factor levels in elderly korean with dementia. Psychiatry Investig (2009) 1.04

BDNF, TNFα, HSP90, CFH, and IL-10 serum levels in patients with early or late onset Alzheimer's disease or mild cognitive impairment. J Alzheimers Dis (2013) 1.04

Brain-derived neurotrophic factor levels in Alzheimer's disease. J Alzheimers Dis (2009) 1.03

Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease. Biomed Res Int (2014) 1.01

Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord (2013) 1.01

Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels. Curr Alzheimer Res (2010) 1.01

Serum brain-derived neurotrophic factor levels in different neurological diseases. Biomed Res Int (2013) 1.01

Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci (2013) 1.01

Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease. J Psychiatr Res (2014) 0.99

A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. J Neurochem (2002) 0.99

Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. Int J Dev Neurosci (2000) 0.99

Assessing publication bias in meta-analysis. Nurs Res (2003) 0.99

Autophagy has a key role in the pathophysiology of schizophrenia. Mol Psychiatry (2013) 0.99

Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α. Mol Psychiatry (2015) 0.99

The neurotrophins and their role in Alzheimer's disease. Curr Neuropharmacol (2011) 0.98

Galanin protects amyloid-beta-induced neurotoxicity on primary cultured hippocampal neurons of rats. J Alzheimers Dis (2010) 0.98

Peripheral brain-derived neurotrophic factor in schizophrenia and the role of antipsychotics: meta-analysis and implications. Mol Psychiatry (2014) 0.96

Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease. J Proteomics (2012) 0.94

ApoE4 and Aβ Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation. J Neurosci (2015) 0.93

Acute aerobic exercise increases brain-derived neurotrophic factor levels in elderly with Alzheimer's disease. J Alzheimers Dis (2014) 0.93

Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: a longitudinal study. J Psychiatr Res (2013) 0.92

A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. Front Aging Neurosci (2014) 0.91

A role for the BDNF gene Val66Met polymorphism in schizophrenia? A comprehensive review. Neurosci Biobehav Rev (2015) 0.91

Decreased brain-derived neurotrophic factor (BDNF)- and beta-thromboglobulin (beta-TG)- blood levels in Alzheimer's disease. Thromb Haemost (2006) 0.91

The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease. J Neuroimmunol (2015) 0.90

GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression. Prog Neuropsychopharmacol Biol Psychiatry (2013) 0.90

Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: pitfalls and solutions. J Neurosci Methods (2010) 0.88

Physical exercise in MCI elderly promotes reduction of pro-inflammatory cytokines and improvements on cognition and BDNF peripheral levels. Curr Alzheimer Res (2014) 0.87

Decreased Neurotrophic Support is Associated with Cognitive Decline in Non-Demented Subjects. J Alzheimers Dis (2015) 0.86

Memory loss in Alzheimer's disease: implications for development of therapeutics. Expert Rev Neurother (2008) 0.85

Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions. Trans Am Clin Climatol Assoc (2015) 0.85

The stimulation of dendritic cells by amyloid beta 1-42 reduces BDNF production in Alzheimer's disease patients. Brain Behav Immun (2013) 0.85

Psychophysiological correlates of cognitive deficits in family caregivers of patients with Alzheimer Disease. Neuroscience (2014) 0.84

Association of rs6265 and rs2030324 polymorphisms in brain-derived neurotrophic factor gene with Alzheimer's disease: a meta-analysis. PLoS One (2014) 0.83

New perspectives on the role of tau in Alzheimer's disease. Implications for therapy. Biochem Pharmacol (2014) 0.83

Cognitive function in elderly marathon runners: cross-sectional data from the marathon trial (APSOEM). Wien Klin Wochenschr (2010) 0.82

Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease. Biochem Biophys Res Commun (2012) 0.82

The associations between serum brain-derived neurotrophic factor, potential confounders, and cognitive decline: a longitudinal study. PLoS One (2014) 0.82

Amyloid β, glutamate, excitotoxicity in Alzheimer's disease: are we on the right track? CNS Neurosci Ther (2013) 0.82

Brain-derived neurotrophic factor plasma levels: relationship with dementia and diabetes in the elderly population. J Gerontol A Biol Sci Med Sci (2014) 0.82

Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease. Dement Geriatr Cogn Dis Extra (2015) 0.81

Blood-Based Proteomic Biomarkers of Alzheimer's Disease Pathology. Front Neurol (2015) 0.81

Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. Pharmacol Biochem Behav (2014) 0.81

Apathy and APOE4 are associated with reduced BDNF levels in Alzheimer's disease. J Alzheimers Dis (2014) 0.81