Published in Br J Cancer on May 03, 2016
DNA Repair Inhibitor & Irradiation on Melanoma (DRIIM) | NCT01469455
Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy. Oncotarget (2016) 0.77
Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics with a Combination of AsiDNA and PARP Inhibitors. Clin Cancer Res (2016) 0.75
Skin cancer: DT01 DNA-repair inhibitor shows promise. Nat Rev Clin Oncol (2016) 0.75
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Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med (2013) 18.08
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DNA repair pathways as targets for cancer therapy. Nat Rev Cancer (2008) 6.69
Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med (2014) 5.65
Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma. Clin Cancer Res (2011) 2.52
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An interesting case of possible abscopal effect in malignant melanoma. Br J Radiol (1975) 1.72
Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling. Pigment Cell Melanoma Res (2007) 1.45
Colorectal cancer metastasis: the DNA repair inhibitor Dbait increases sensitivity to hyperthermia and improves efficacy of radiofrequency ablation. Radiology (2013) 1.45
The melanoma revolution: from UV carcinogenesis to a new era in therapeutics. Science (2014) 1.37
Small-molecule drugs mimicking DNA damage: a new strategy for sensitizing tumors to radiotherapy. Clin Cancer Res (2009) 1.25
Ipilimumab (yervoy) prolongs survival in advanced melanoma: serious side effects and a hefty price tag may limit its use. P T (2012) 1.19
Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response. PLoS One (2009) 1.18
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DNA repair pathways in drug resistance in melanoma. Anticancer Drugs (2004) 0.98
Skin metastases of malignant melanoma: a clinical and prognostic survey. Melanoma Res (2009) 0.96
Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration. Angiogenesis (2013) 0.95
A higher radiotherapy dose is associated with more durable palliation and longer survival in patients with metastatic melanoma. Cancer (2007) 0.94
Long-term survival in patients with metastatic melanoma treated with DTIC or temozolomide. Oncologist (2010) 0.92
Malignant melanoma: analysis of dose fractionation in radiation therapy. Radiology (1987) 0.90
Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait: A Therapeutic Double-stranded DNA Oligonucleotide Conjugated to Cholesterol. Mol Ther Nucleic Acids (2012) 0.87
Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer. J Gastroenterol (2011) 0.87
Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems. Cancer Gene Ther (2011) 0.87
A preclinical study combining the DNA repair inhibitor Dbait with radiotherapy for the treatment of melanoma. Neoplasia (2014) 0.85
The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis. Mol Cancer Ther (2015) 0.81