Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6.

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Published in Oncoimmunology on October 29, 2015

Authors

Christiane R Stadler1, Hayat Bähr-Mahmud1, Laura M Plum1, Kathrin Schmoldt1, Anne C Kölsch2, Özlem Türeci3, Ugur Sahin4

Author Affiliations

1: Biopharmaceutical New Technologies (BioNTech) AG, Mainz, Germany; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany.
2: TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH , Mainz, Germany.
3: Ganymed Pharmaceuticals AG , Mainz, Germany.
4: Biopharmaceutical New Technologies (BioNTech) AG, Mainz, Germany; TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Mainz, Germany; Department for Internal Medicine, Johannes Gutenberg University, III; Mainz, Germany.

Associated clinical trials:

Phase 1/2 Trial of IMAB027 in Patients With Recurrent Advanced Ovarian Cancer (OVAR) (OVAR) | NCT02054351

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