Published in PLoS One on May 11, 2016
Apoptosis in the pathogenesis and treatment of disease. Science (1995) 20.24
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem (1997) 9.97
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (1998) 8.93
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature (1996) 7.27
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem (1998) 6.84
Profiling enzyme activities in vivo using click chemistry methods. Chem Biol (2004) 5.97
Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol (2006) 4.82
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell (2006) 4.53
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell (2004) 4.38
Apoptotic pathways: paper wraps stone blunts scissors. Cell (2000) 4.37
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol (2000) 3.58
From bench to clinic with apoptosis-based therapeutic agents. Nature (2000) 2.96
Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A (2008) 2.74
Fluorescent protein FRET pairs for ratiometric imaging of dual biosensors. Nat Methods (2008) 2.56
Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ (2007) 2.48
Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis. Nat Methods (2005) 2.33
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09
Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene (2002) 2.03
Noninvasive real-time imaging of apoptosis. Proc Natl Acad Sci U S A (2002) 1.93
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nat Med (2009) 1.90
The use of cell-penetrating peptides as a tool for gene regulation. Drug Discov Today (2004) 1.90
Cell penetrating peptides in drug delivery. Pharm Res (2004) 1.86
Activity-based protein profiling for biochemical pathway discovery in cancer. Nat Rev Cancer (2010) 1.84
TAT peptide internalization: seeking the mechanism of entry. Curr Protein Pept Sci (2003) 1.66
Protease specificity determination by using cellular libraries of peptide substrates (CLiPS). Proc Natl Acad Sci U S A (2006) 1.33
Caspase-3 in the central nervous system: beyond apoptosis. Trends Neurosci (2012) 1.30
Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity. Mol Cell Proteomics (2009) 1.27
Apoptosis and carcinogenesis. Br J Cancer (1999) 1.21
Progress and prospects: nuclear import of nonviral vectors. Gene Ther (2010) 1.17
Application of activity-based probes to the study of enzymes involved in cancer progression. Curr Opin Genet Dev (2008) 1.17
The role of radiation-induced and spontaneous apoptosis in the homeostasis of the gastrointestinal epithelium: a brief review. Comp Biochem Physiol B Biochem Mol Biol (1997) 1.11
Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis. FEBS J (2007) 1.09
Functional imaging of legumain in cancer using a new quenched activity-based probe. J Am Chem Soc (2012) 1.05
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chem Biol (2010) 1.02
An optimized activity-based probe for the study of caspase-6 activation. Chem Biol (2012) 0.97
Quantification of active caspase 3 in apoptotic cells. Anal Biochem (2000) 0.95
FLIM-FRET Imaging of Caspase-3 Activity in Live Cells Using Pair of Red Fluorescent Proteins. Theranostics (2012) 0.92
Synthesis, penetrability and intracellular targeting of fluorescein-tagged peptoids and peptide-peptoid hybrids. Bioorg Med Chem (2008) 0.91
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates. Cell Death Differ (2014) 0.89
A substrate-phage approach for investigating caspase specificity. Protein J (2004) 0.88
Multi-modal molecular imaging approaches to detect primary cells in preclinical models. Faraday Discuss (2011) 0.82
Selective detection of caspase-3 versus caspase-7 using activity-based probes with key unnatural amino acids. ACS Chem Biol (2013) 0.82
A peptide aldehyde microarray for high-throughput profiling of cellular events. J Am Chem Soc (2011) 0.82
Discovery of a highly selective caspase-3 substrate for imaging live cells. ACS Chem Biol (2014) 0.81
Microsphere-based intracellular sensing of caspase-3/7 in apoptotic living cells. Macromol Biosci (2014) 0.79
Eliminating caspase-7 and cathepsin B cross-reactivity on fluorogenic caspase-3 substrates. Mol Biosyst (2016) 0.77
Flow and Microwave-Assisted Synthesis of N-(Triethylene glycol)glycine Oligomers and Their Remarkable Cellular Transporter Activities. Bioconjug Chem (2015) 0.76