Published in J Am Chem Soc on May 18, 2016
Identification of the first marine-derived opioid receptor "balanced" agonist with a signaling profile that resembles the endorphins. ACS Chem Neurosci (2016) 0.75
Molecular Docking, Molecular Dynamics, and Structure-Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists. ACS Chem Neurosci (2017) 0.75
Mitragyna speciosa: Balancing Potential Medical Benefits and Abuse. ACS Med Chem Lett (2017) 0.75
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem (2009) 23.19
Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature (2012) 6.18
The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci (2008) 3.54
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther (2003) 3.48
An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Mol Pharmacol (2006) 2.06
Crystal structure of venus, a yellow fluorescent protein with improved maturation and reduced environmental sensitivity. J Biol Chem (2002) 1.87
Clinical pharmacology of opioids for pain. Clin J Pain (2002) 1.85
Structural insights into µ-opioid receptor activation. Nature (2015) 1.77
Mu opioids and their receptors: evolution of a concept. Pharmacol Rev (2013) 1.66
A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther (2013) 1.62
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kappa-Opioid receptor signaling and brain reward function. Brain Res Rev (2009) 1.32
Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes. J Mol Biol (2011) 1.31
Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. Br J Pharmacol (2010) 1.30
Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems. Eur J Pharmacol (1996) 1.29
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Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats. Life Sci (2002) 1.13
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Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. J Med Chem (2002) 1.11
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Safety, tolerability, and clinical effect of low-dose buprenorphine for treatment-resistant depression in midlife and older adults. J Clin Psychiatry (2014) 1.08
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Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity. Curr Top Med Chem (2011) 0.99
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression. Phytomedicine (2011) 0.98
Treatment of refractory major depression with tramadol monotherapy. J Clin Psychiatry (2001) 0.97
Open-label pilot study of tramadol hydrochloride in treatment-refractory obsessive-compulsive disorder. Depress Anxiety (1997) 0.95
Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence. Eur Psychiatry (2004) 0.94
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Antidepressant-like effect of endomorphin-1 and endomorphin-2 in mice. Neuropsychopharmacology (2006) 0.88
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Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A. Nat Prod Commun (2009) 0.87
Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA. J Pharmacol Exp Ther (2014) 0.85
Orally active opioid compounds from a non-poppy source. J Med Chem (2013) 0.84
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Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor. J Biol Chem (2014) 0.82
Antagonists of the kappa opioid receptor. Bioorg Med Chem Lett (2014) 0.82
The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist. Transl Psychiatry (2014) 0.80
Effects of morphine, naloxone and their interaction in the learned-helplessness paradigm in rats. Psychopharmacology (Berl) (1996) 0.79
Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice. J Pharmacol Exp Ther (2013) 0.79
The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence. Pharmacol Biochem Behav (2015) 0.77
C-H bond functionalization in complex organic synthesis. Science (2006) 3.76
Direct palladium-catalyzed C-2 and C-3 arylation of indoles: a mechanistic rationale for regioselectivity. J Am Chem Soc (2005) 1.82
sp3 C-H bond arylation directed by amidine protecting group: alpha-arylation of pyrrolidines and piperidines. J Am Chem Soc (2006) 1.40
Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals. Science (2009) 1.39
Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine. J Clin Oncol (2003) 1.37
C-C bond formation via C-H bond activation: synthesis of the core of teleocidin B4. J Am Chem Soc (2002) 1.35
Direct C-arylation of free (NH)-indoles and pyrroles catalyzed by Ar-Rh(III) complexes assembled in situ. J Am Chem Soc (2005) 1.32
Room temperature hydroalkylation of electron-deficient olefins: sp3 C-H functionalization via a lewis acid-catalyzed intramolecular redox event. J Am Chem Soc (2005) 1.31
Pt(IV)-catalyzed cyclization of arene-alkyne substrates via intramolecular electrophilic hydroarylation. Org Lett (2003) 1.29
Catalytic C-H arylation of SEM-protected azoles with palladium complexes of NHCs and phosphines. Org Lett (2006) 1.25
Reactivity of functional groups on the protein surface: development of epoxide probes for protein labeling. J Am Chem Soc (2003) 1.25
Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain. Proc Natl Acad Sci U S A (2012) 1.20
Retracted C-C bond formation via C-H bond activation: catalytic arylation and alkenylation of alkane segments. J Am Chem Soc (2002) 1.18
C-H bond functionalization via hydride transfer: Lewis acid catalyzed alkylation reactions by direct intramolecular coupling of sp3 C-H bonds and reactive alkenyl oxocarbenium intermediates. J Am Chem Soc (2009) 1.14
Room temperature intramolecular hydro-O-alkylation of aldehydes: sp3 C-H functionalization via a Lewis acid catalyzed tandem 1,5-hydride transfer/cyclization. Org Lett (2005) 1.13
Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains. J Am Chem Soc (2002) 1.13
Cross-coupling of sp(3) C-H bonds and alkenes: catalytic cyclization of alkene-amide substrates. J Am Chem Soc (2004) 1.09
Total synthesis of (-)-rhazinilam: asymmetric C[bond]H bond activation via the use of a chiral auxiliary. J Am Chem Soc (2002) 1.05
Ru(III)-catalyzed cyclization of arene-alkene substrates via intramolecular electrophilic hydroarylation. Org Lett (2004) 1.04
Retracted Oxidative C-arylation of free (NH)-heterocycles via direct (sp3) C-H bond functionalization. J Am Chem Soc (2004) 1.03
Direct C-H bond arylation: selective palladium-catalyzed C2-arylation of N-substituted indoles. Org Lett (2004) 1.00
Retracted Selective and catalytic arylation of N-phenylpyrrolidine: sp3 C-H bond functionalization in the absence of a directing group. J Am Chem Soc (2005) 0.99
Phosphine-free palladium-catalyzed C-H bond arylation of free (N-H)-indoles and pyrroles. J Org Chem (2007) 0.99
C-H bond functionalization via hydride transfer: synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers. Org Lett (2009) 0.97
Selective and catalytic arylation of N-phenylpyrrolidine: (sp3) C-H bond functionalization in the absence of a directing group [J. Am. Chem. Soc. 2005, 127, 5284-5285]. J Am Chem Soc (2006) 0.97
Oxidative C-arylation of free (NH)-heterocycles via direct sp3 C-H bond functionalization [J. Am. Chem. Soc. 2004, 126, 13244-13246]. J Am Chem Soc (2006) 0.96
Development of pH-responsive fluorescent false neurotransmitters. J Am Chem Soc (2010) 0.94
Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng. J Am Chem Soc (2008) 0.93
Retracted Diversity synthesis via C-H bond functionalization: concept-guided development of new C-arylation methods for imidazoles. J Am Chem Soc (2003) 0.93
A luminescent sensor for tyrosine phosphorylation. Org Lett (2007) 0.90
C-H arylation of pyridines: high regioselectivity as a consequence of the electronic character of C-H bonds and heteroarene ring. J Am Chem Soc (2011) 0.90
Design of optical switches as metabolic indicators: new fluorogenic probes for monoamine oxidases (MAO A and B). J Am Chem Soc (2005) 0.90
Retracted Selective C-arylation of free (NH)-heteroarenes via catalytic C-H bond functionalization. J Am Chem Soc (2003) 0.89
Complementation of biotransformations with chemical C-H oxidation: copper-catalyzed oxidation of tertiary amines in complex pharmaceuticals. J Am Chem Soc (2013) 0.88
C-H bond functionalization via hydride transfer: direct coupling of unactivated alkynes and sp(3) C-H bonds catalyzed by platinum tetraiodide. J Am Chem Soc (2009) 0.88
Cocktails of Tb(3+) and Eu(3+) complexes: a general platform for the design of ratiometric optical probes. J Am Chem Soc (2007) 0.87
Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles. J Am Chem Soc (2007) 0.87
C-H bonds as ubiquitous functionality: a general approach to complex arylated pyrazoles via sequential regioselective C-arylation and N-alkylation enabled by SEM-group transposition. J Am Chem Soc (2009) 0.87
New tools for molecular imaging of redox metabolism: development of a fluorogenic probe for 3 alpha-hydroxysteroid dehydrogenases. J Am Chem Soc (2004) 0.86
Harnessing functional plasticity of enzymes: a fluorogenic probe for imaging 17beta-HSD10 dehydrogenase, an enzyme involved in Alzheimer's and Parkinson's diseases. J Am Chem Soc (2007) 0.85
A new fluorogenic transformation: development of an optical probe for coenzyme Q. Org Lett (2005) 0.84
New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2). ACS Chem Biol (2013) 0.84
Concise synthesis of the chemopreventitive agent (+/-)-deguelin via a key 6-endo hydroarylation. Org Lett (2003) 0.84
Transposing molecular fluorescent switches into the near-IR: development of luminogenic reporter substrates for redox metabolism. J Am Chem Soc (2007) 0.84
APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter. ACS Chem Neurosci (2013) 0.83
NeuO: a fluorescent chemical probe for live neuron labeling. Angew Chem Int Ed Engl (2015) 0.82
Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells. Proc Natl Acad Sci U S A (2006) 0.81
Phosphorylation state-responsive lanthanide peptide conjugates: a luminescence switch based on reversible complex reorganization. Org Lett (2006) 0.79
Catalytic coupling of arene C-H bonds and alkynes for the synthesis of coumarins: substrate scope and application to the development of neuroimaging agents. J Org Chem (2012) 0.79
Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor. J Chem Inf Model (2015) 0.78
Fluoromorphic substrates for fatty acid metabolism: highly sensitive probes for mammalian medium-chain acyl-CoA dehydrogenase. Angew Chem Int Ed Engl (2006) 0.78
C-H bond functionalization via hydride transfer: formation of α-arylated piperidines and 1,2,3,4-tetrahydroisoquinolines via stereoselective intramolecular amination of benzylic C-H bonds. J Org Chem (2012) 0.78
(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells. ACS Chem Biol (2010) 0.78
Paradoxical abatement of striatal dopaminergic transmission by cocaine and methylphenidate. J Biol Chem (2013) 0.77
Site-specific phenylation of pyridine catalyzed by phosphido-bridged ruthenium dimer complexes: a prototype for C-H arylation of electron-deficient heteroarenes. J Am Chem Soc (2005) 0.77
Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles. Biochemistry (2016) 0.77
Two-photon induced uncaging of a reactive intermediate. Multiphoton in situ detection of a potentially valuable label for biological applications. J Org Chem (2005) 0.76
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers. ACS Chem Neurosci (2016) 0.76
Expanding the use of fluorogenic enzyme reporter substrates to imaging metabolic flux changes: the activity measurement of 5α-steroid reductase in intact mammalian cells. ACS Chem Biol (2010) 0.76
Dopamine release at individual presynaptic terminals visualized with FFNs. J Vis Exp (2009) 0.75
Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors. ACS Chem Biol (2016) 0.75
C-H bonds as ubiquitous functionality: preparation of multiple regioisomers of arylated 1,2,4-triazoles via C-H arylation. J Org Chem (2012) 0.75
Synthesis of luminescent heterometallic bis-lanthanide complexes via selective, sequential metallation. Chem Commun (Camb) (2006) 0.75
Cobalt-catalyzed arylation of azole heteroarenes via direct C-H bond functionalization. Org Lett (2003) 0.75
Intermolecular energy transfer from Tb3+ to Eu3+ in aqueous aggregates and on the surface of human cells. Org Lett (2011) 0.75
Identification of fluorescent small molecule compounds for synaptic labeling by image-based, high-content screening. ACS Chem Neurosci (2017) 0.75
Constructing Iboga alkaloids via C-H bond functionalization: examination of the direct and catalytic union of heteroarenes and isoquinuclidine alkenes. J Org Chem (2015) 0.75