Published in Oncotarget on June 21, 2016
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol (2005) 7.80
Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity (2005) 6.48
Identification of Tim4 as a phosphatidylserine receptor. Nature (2007) 6.06
Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. Immunity (2006) 5.32
A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J Exp Med (2000) 5.11
TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity (2007) 4.49
Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. Nat Rev Immunol (2008) 4.17
Identification of a novel population of Langerin+ dendritic cells. J Exp Med (2007) 4.13
Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity (2005) 4.06
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol (2001) 4.05
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol (2005) 3.00
The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol (2003) 2.90
CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. J Exp Med (2009) 2.75
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med (2012) 2.69
Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses. Immunity (2011) 2.58
Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev (2010) 2.44
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A (2010) 2.41
Langerhans cell as primary target and vehicle for transmission of HIV. Lancet (1987) 2.40
Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. Immunity (2007) 2.29
TIM-4 expressed by mucosal dendritic cells plays a critical role in food antigen-specific Th2 differentiation and intestinal allergy. Gastroenterology (2007) 2.25
Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc Natl Acad Sci U S A (2009) 2.12
Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med (2007) 1.93
Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity (2012) 1.81
Mouse lymphoid tissue contains distinct subsets of langerin/CD207 dendritic cells, only one of which represents epidermal-derived Langerhans cells. J Invest Dermatol (2005) 1.78
Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells. J Immunol (2007) 1.75
TIM-1, a novel allergy and asthma susceptibility gene. Springer Semin Immunopathol (2003) 1.72
Novel subset of CD8{alpha}+ dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J Immunol (2009) 1.66
Insights into Langerhans cell function from Langerhans cell ablation models. Eur J Immunol (2008) 1.65
Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med (2005) 1.63
Update of immune events in the murine contact hypersensitivity model: toward the understanding of allergic contact dermatitis. J Invest Dermatol (2012) 1.52
The phosphatidylserine receptor TIM-4 does not mediate direct signaling. Curr Biol (2009) 1.45
Two distinct types of Langerhans cells populate the skin during steady state and inflammation. Immunity (2012) 1.36
Dendritic cell subsets and the regulation of Th1/Th2 responses. Semin Immunol (2001) 1.34
Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model. J Allergy Clin Immunol (2008) 1.34
Functional redundancy of Langerhans cells and Langerin+ dermal dendritic cells in contact hypersensitivity. J Invest Dermatol (2010) 1.31
TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur J Immunol (2009) 1.28
The origins and functions of dendritic cells and macrophages in the skin. Nat Rev Immunol (2014) 1.25
Bimodal regulation of T cell-mediated immune responses by TIM-4. Int Immunol (2008) 1.23
Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity. J Allergy Clin Immunol (2010) 1.21
Novel roles for TIM-1 in immunity and infection. Immunol Lett (2011) 1.17
Impaired Langerhans cell migration in psoriasis. J Exp Med (2006) 1.16
Priming of CD8+ and CD4+ T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes. J Immunol (2009) 1.13
TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells. J Immunol (2010) 1.10
Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest (2012) 1.09
Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells. Eur J Immunol (2004) 1.09
Antigen presentation by Langerhans cells. Curr Opin Immunol (2012) 1.08
Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg. Eur J Immunol (2010) 1.07
SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling. Eur J Immunol (2004) 1.06
Langerhans cells: critical regulators of skin immunity? Immunol Cell Biol (2010) 1.03
Staphylococcal enterotoxin B increases TIM4 expression in human dendritic cells that drives naïve CD4 T cells to differentiate into Th2 cells. Mol Immunol (2007) 1.03
Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells. J Immunol (2009) 1.02
The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity. Allergy Asthma Proc (2013) 1.01
Langerhans cells favor skin flora tolerance through limited presentation of bacterial antigens and induction of regulatory T cells. J Invest Dermatol (2013) 0.95
Glucocorticosteroids modify Langerhans cells to produce TGF-β and expand regulatory T cells. J Immunol (2010) 0.95
Lack of microRNA miR-150 reduces the capacity of epidermal Langerhans cell cross-presentation. Exp Dermatol (2012) 0.93
Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance. EMBO Mol Med (2014) 0.89
Deletion of microRNA miR-223 increases Langerhans cell cross-presentation. Int J Biochem Cell Biol (2012) 0.88
TIM-4, expressed by medullary macrophages, regulates respiratory tolerance by mediating phagocytosis of antigen-specific T cells. Mucosal Immunol (2012) 0.88
TGFβ/Smad3 signal pathway is not required for epidermal Langerhans cell development. J Invest Dermatol (2012) 0.86
Human skin dendritic cells in health and disease. J Dermatol Sci (2014) 0.86
The impact of the TIM gene family on tumor immunity and immunosuppression. Cell Mol Immunol (2013) 0.85
Histone deacetylases inhibitor Trichostatin A ameliorates DNFB-induced allergic contact dermatitis and reduces epidermal Langerhans cells in mice. J Dermatol Sci (2012) 0.84
Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol (2013) 0.84
Aging affects epidermal Langerhans cell development and function and alters their miRNA gene expression profile. Aging (Albany NY) (2012) 0.82
Leishmaniasis, contact hypersensitivity and graft-versus-host disease: understanding the role of dendritic cell subsets in balancing skin immunity and tolerance. Exp Dermatol (2010) 0.81
microRNA miR-17-92 cluster is highly expressed in epidermal Langerhans cells but not required for its development. Genes Immun (2013) 0.81
Dissolving microneedle delivery of nanoparticle-encapsulated antigen elicits efficient cross-priming and Th1 immune responses by murine Langerhans cells. J Invest Dermatol (2014) 0.81
The balance between immunity and tolerance: the role of Langerhans cells. Cell Mol Life Sci (2009) 0.79
The contribution of Langerhans cells to cutaneous malignancy. Trends Immunol (2010) 0.79
Evidence for a role of Langerhans cell-derived IL-16 in atopic dermatitis. J Allergy Clin Immunol (2002) 0.78
Histone deacetylase activity is required for skin Langerhans cell maturation and phagocytosis. J Dermatol Sci (2011) 0.78
Analysis of capturing skin antigens in the steady state using milk fat globule EGF factor 8-deficient skin-hyperpigmented mice. Immunol Lett (2007) 0.76
Novel insights into Tim-4 function in autoimmune diseases. Autoimmunity (2014) 0.76
Peptidoglycan-induced T helper 2 immune response in mice involves interleukin-10 secretion from Langerhans cells. Microbiol Immunol (2013) 0.76
TIM-family molecules in embryonic hematopoiesis: fetal liver TIM-4(lo) cells have myeloid potential. Exp Hematol (2013) 0.76