BRAF kinase inhibitor exerts anti-tumor activity against breast cancer cells via inhibition of FGFR2.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27293997)

Published in Am J Cancer Res on May 01, 2016

Authors

Zong Xin Zhang1, Wen Jun Jin1, Sheng Yang2, Cun Li Ji2

Author Affiliations

1: Department of Clinical Laboratory, Huzhou Central Hospital No. 198, Hongqi Road, Huzhou 313000, Zhejiang Province, China.
2: Department of Breast Medical Care, Huzhou Maternity and Child Health Care Hospital Wuxing District, East Street 2, Huzhou 313000, Zhejiang Province, China.

Articles cited by this

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations. N Engl J Med (2015) 4.78

The akt kinase: molecular determinants of oncogenicity. Proc Natl Acad Sci U S A (1998) 2.99

Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor. Oncologist (2015) 1.13

Tumour Angiogenesis and Angiogenic Inhibitors: A Review. J Clin Diagn Res (2015) 1.09

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth. Prog Biophys Mol Biol (2013) 0.93

Phosphorylated VEGFR2 and hypertension: potential biomarkers to indicate VEGF-dependency of advanced breast cancer in anti-angiogenic therapy. Breast Cancer Res Treat (2013) 0.92

Anti-VEGF and beyond: shaping a new generation of anti-angiogenic therapies for cancer. Drug Discov Today (2011) 0.91

A VEGFR1 antagonistic peptide inhibits tumor growth and metastasis through VEGFR1-PI3K-AKT signaling pathway inhibition. Am J Cancer Res (2015) 0.89

The role of dietary factors in prevention and progression of breast cancer. Anticancer Res (2014) 0.87

Novel mechanisms of resistance to vemurafenib in melanoma - V600E B-Raf reversion and switching VEGF-A splice isoform expression. Am J Cancer Res (2014) 0.85

Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cells. Oncotarget (2015) 0.85

Indigo naturalis and its component tryptanthrin exert anti-angiogenic effect by arresting cell cycle and inhibiting Akt and FAK signaling in human vascular endothelial cells. J Ethnopharmacol (2015) 0.83

Silencing of CCR7 inhibits the growth, invasion and migration of prostate cancer cells induced by VEGFC. Int J Clin Exp Pathol (2015) 0.82

Trastuzumab increases the sensitivity of HER2-amplified human gastric cancer cells to oxaliplatin and cisplatin by affecting the expression of telomere-associated proteins. Oncol Lett (2014) 0.82

12-Deoxyphorbol 13-palmitate inhibits the expression of VEGF and HIF-1α in MCF-7 cells by blocking the PI3K/Akt/mTOR signaling pathway. Oncol Rep (2015) 0.82

Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells. Oncotarget (2015) 0.82

Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci (2015) 0.81

Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs. Cell Death Differ (2015) 0.81

Antiangiogenic Effect of Ethanol Extract of Vigna angularis via Inhibition of Phosphorylation of VEGFR2, Erk, and Akt. Evid Based Complement Alternat Med (2015) 0.80

A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J Biol Chem (2014) 0.80

Clopidogrel inhibits angiogenesis of gastric ulcer healing via downregulation of vascular endothelial growth factor receptor 2. J Formos Med Assoc (2015) 0.79

Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9. Nutr Cancer (2015) 0.79

Novel mechanisms and approaches in the medical therapy of solid cancers. Discov Med (2015) 0.79

Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1. Int J Clin Exp Med (2015) 0.78