Cannabidiol Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System.

PubWeight™: 0.77‹?›

🔗 View Article (PMID 27296152)

Published in Neuropsychopharmacology on June 14, 2016

Authors

Christopher Norris1,2, Michael Loureiro1,2, Cecilia Kramar1,2, Jordan Zunder1,2, Justine Renard3,2, Walter Rushlow1,2,4, Steven R Laviolette1,2,4,5

Author Affiliations

1: Addiction Research Group, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
2: Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
3: Addiction Research Group, University of Western Ontario, London, ON, Canada.
4: Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
5: Department of Psychology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.

Articles cited by this

Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science (2004) 5.62

Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study. BMJ (2011) 3.84

The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol (2007) 3.16

Cannabidiol--recent advances. Chem Biodivers (2007) 2.89

Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol (2001) 2.15

Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci (2005) 2.13

Cannabis, the mind and society: the hash realities. Nat Rev Neurosci (2007) 1.99

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol (2007) 1.85

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl Psychiatry (2012) 1.77

Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res (2006) 1.76

Dopamine D1 versus D4 receptors differentially modulate the encoding of salient versus nonsalient emotional information in the medial prefrontal cortex. J Neurosci (2009) 1.60

Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. Neuroscience (1978) 1.57

Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res (2005) 1.54

GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area. Neuroscience (1993) 1.50

Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. Neuroreport (1997) 1.48

Comparative receptor binding analyses of cannabinoid agonists and antagonists. J Pharmacol Exp Ther (1998) 1.48

Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. Arch Gen Psychiatry (2009) 1.40

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. J Psychopharmacol (2010) 1.31

Biologically active cannabinoids from high-potency Cannabis sativa. J Nat Prod (2009) 1.27

Increased fear response to contextual cues in mice lacking the 5-HT1A receptor. Neuropsychopharmacology (2006) 1.24

Neuronal circuits underlying acute morphine action on dopamine neurons. Proc Natl Acad Sci U S A (2011) 1.23

Facilitation of contextual fear memory extinction and anti-anxiogenic effects of AM404 and cannabidiol in conditioned rats. Eur Neuropsychopharmacol (2008) 1.18

Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. Br J Pharmacol (2015) 1.12

Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing. Arch Gen Psychiatry (2012) 1.07

Cannabidiol enhances consolidation of explicit fear extinction in humans. Psychopharmacology (Berl) (2013) 0.97

On disruption of fear memory by reconsolidation blockade: evidence from cannabidiol treatment. Neuropsychopharmacology (2012) 0.93

Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects. Neuropharmacology (2009) 0.90

A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation. Curr Pharm Des (2012) 0.89

Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience. Eur Neuropsychopharmacol (2013) 0.87

Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus. Addict Biol (2012) 0.86

R(+)-8-OH-DPAT, a 5-HT1A receptor agonist, inhibits amphetamine-induced dopamine release in rat striatum and nucleus accumbens. Eur J Pharmacol (1995) 0.86

Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum. Life Sci (2004) 0.84

Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics (2015) 0.84

Higher in vivo serotonin-1a binding in posttraumatic stress disorder: a PET study with [11C]WAY-100635. Depress Anxiety (2013) 0.84

Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol. Schizophr Res (2015) 0.83

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats. FEBS Lett (2006) 0.82

Cannabidiol as a potential treatment for psychosis. Eur Neuropsychopharmacol (2013) 0.82

Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway. J Neurosci (2016) 0.81

Hippocampal cannabinoid transmission modulates dopamine neuron activity: impact on rewarding memory formation and social interaction. Neuropsychopharmacology (2014) 0.81

Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine. Psychopharmacology (Berl) (2015) 0.81

Effects of intra-infralimbic prefrontal cortex injections of cannabidiol in the modulation of emotional behaviors in rats: contribution of 5HT₁A receptors and stressful experiences. Behav Brain Res (2015) 0.81

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychopharmacol (2009) 0.80

Adolescent Cannabinoid Exposure Induces a Persistent Sub-Cortical Hyper-Dopaminergic State and Associated Molecular Adaptations in the Prefrontal Cortex. Cereb Cortex (2017) 0.79

Use and effects of cannabinoids in military veterans with posttraumatic stress disorder. Am J Health Syst Pharm (2015) 0.79

Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors. J Psychiatr Res (2012) 0.79

Serotonin 5-HT1A receptors mediate inhibition of tyrosine hydroxylation in rat striatum. J Pharmacol Exp Ther (1993) 0.78

Opiate Exposure State Controls a D2-CaMKIIα-Dependent Memory Switch in the Amygdala-Prefrontal Cortical Circuit. Neuropsychopharmacology (2015) 0.78

Cannabinoid transmission in the prefrontal cortex bi-phasically controls emotional memory formation via functional interactions with the ventral tegmental area. J Neurosci (2014) 0.78

Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats. Neurosci Res (2014) 0.76

5-HT(1A) and 5-HT(1B) receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats. J Oral Sci (2008) 0.76