HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27311750)

Published in J Infect on June 14, 2016

Authors

Emmie W Mbale1, Christopher A Moxon2, Mavuto Mukaka3, Maganizo Chagomerana4, Simon Glover5, Ngawina Chisala3, Sofia Omar6, Malcolm Molyneux7, Karl Seydel8, Alister G Craig9, Terrie Taylor8, Robert S Heyderman10, Macpherson Mallewa1

Author Affiliations

1: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Malawi; Department of Paediatrics, University of Malawi College of Medicine, Malawi.
2: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Malawi; Institute of Infection and Global Health, University of Liverpool, UK. Electronic address: cmoxon@liverpool.ac.uk.
3: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Malawi.
4: Blantyre Malaria Project, University of Malawi College of Medicine, Malawi.
5: School of Medicine, University of St. Andrews, UK.
6: Department of Paediatrics, University of Malawi College of Medicine, Malawi.
7: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Malawi; Liverpool School of Tropical Medicine, UK.
8: Blantyre Malaria Project, University of Malawi College of Medicine, Malawi; College of Osteopathic Medicine, Michigan State University, East Lansing, MI, United States.
9: Liverpool School of Tropical Medicine, UK.
10: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Malawi; Liverpool School of Tropical Medicine, UK; University College London, UK.

Articles citing this

EPCR and Malaria Severity: The Center of a Perfect Storm. Trends Parasitol (2016) 0.77

Articles cited by this

Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Q J Med (1989) 10.29

Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med (2004) 7.42

Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med (1989) 6.79

TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet (1990) 6.32

Dual infection with HIV and malaria fuels the spread of both diseases in sub-Saharan Africa. Science (2006) 4.35

HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria. Clin Infect Dis (2009) 2.80

WHO Expert Committee on Malaria. World Health Organ Tech Rep Ser (2000) 2.59

Plasma concentrations of parasite histidine-rich protein 2 distinguish between retinopathy-positive and retinopathy-negative cerebral malaria in Malawian children. J Infect Dis (2012) 2.16

Increased prevalence of severe malaria in HIV-infected adults in South Africa. Clin Infect Dis (2005) 1.81

Cerebral malaria in children: using the retina to study the brain. Brain (2014) 1.53

Brain swelling and death in children with cerebral malaria. N Engl J Med (2015) 1.37

Plasmodium Falciparum malaria and perinatally acquired human immunodeficiency virus type 1 infection in Kinshasa, Zaire. A prospective, longitudinal cohort study of 587 children. N Engl J Med (1991) 1.29

Absence of association between Plasmodium falciparum malaria and human immunodeficiency virus infection in children in Kinshasa, Zaire. Bull World Health Organ (1987) 1.04

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection. MBio (2015) 0.97

Differential PfEMP1 expression is associated with cerebral malaria pathology. PLoS Pathog (2014) 0.93

HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy. AIDS (2013) 0.91