Human Milk: Bioactive Proteins/Peptides and Functional Properties.

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Published in Nestle Nutr Inst Workshop Ser on June 23, 2016

Authors

Bo Lönnerdal

Articles by these authors

(truncated to the top 100)

International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull (2004) 5.76

A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc. Am J Clin Nutr (2003) 1.99

Randomized controlled trial of the effect of daily supplementation with zinc or multiple micronutrients on the morbidity, growth, and micronutrient status of young Peruvian children. Am J Clin Nutr (2004) 1.97

Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr (2014) 1.87

The diagnostic criteria for iron deficiency in infants should be reevaluated. J Nutr (2002) 1.68

Efficacy of rice-based oral rehydration solution containing recombinant human lactoferrin and lysozyme in Peruvian children with acute diarrhea. J Pediatr Gastroenterol Nutr (2007) 1.66

Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women. Am J Clin Nutr (2004) 1.66

Infections in infants fed formula supplemented with bovine milk fat globule membranes. J Pediatr Gastroenterol Nutr (2015) 1.61

Caco-2 cell acquisition of dietary iron(III) invokes a nanoparticulate endocytic pathway. PLoS One (2013) 1.56

Gender and age differences in the metabolism of inorganic arsenic in a highly exposed population in Bangladesh. Environ Res (2007) 1.53

Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. J Biol Chem (2006) 1.52

A follow-up study of nutrient intake, nutritional status, and growth in infants with cow milk allergy fed either a soy formula or an extensively hydrolyzed whey formula. Am J Clin Nutr (2005) 1.49

Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women. J Nutr (2011) 1.49

Sex differences in iron status during infancy. Pediatrics (2002) 1.44

A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development. Am J Clin Nutr (2004) 1.40

Iron supplements reduce erythrocyte copper-zinc superoxide dismutase activity in term, breastfed infants. Acta Paediatr (2005) 1.40

Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues. Am J Clin Nutr (2002) 1.33

Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J Nutr (2003) 1.25

Viral, nutritional, and bacterial safety of flash-heated and pretoria-pasteurized breast milk to prevent mother-to-child transmission of HIV in resource-poor countries: a pilot study. J Acquir Immune Defic Syndr (2005) 1.20

Arsenic methylation efficiency increases during the first trimester of pregnancy independent of folate status. Reprod Toxicol (2010) 1.20

Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in Sweden and Honduras. J Nutr (2002) 1.17

Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status. Am J Clin Nutr (2004) 1.17

Nutritional status has marginal influence on the metabolism of inorganic arsenic in pregnant Bangladeshi women. Environ Health Perspect (2008) 1.16

Proteomic characterization of human milk whey proteins during a twelve-month lactation period. J Proteome Res (2011) 1.12

Influence of iron and zinc status on cadmium accumulation in Bangladeshi women. Toxicol Appl Pharmacol (2007) 1.11

Proteomic characterization of human milk fat globule membrane proteins during a 12 month lactation period. J Proteome Res (2011) 1.07

Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin. Am J Physiol Cell Physiol (2005) 1.07

The human milk metabolome reveals diverse oligosaccharide profiles. J Nutr (2013) 1.07

Cadmium interacts with the transport of essential micronutrients in the mammary gland - a study in rural Bangladeshi women. Toxicology (2008) 1.04

Gender and age differences in mixed metal exposure and urinary excretion. Environ Res (2011) 1.03

Glycosylation of human milk lactoferrin exhibits dynamic changes during early lactation enhancing its role in pathogenic bacteria-host interactions. Mol Cell Proteomics (2012) 1.02

Supplementation of infant formula with the probiotic lactobacillus reuteri and zinc: impact on enteric infection and nutrition in infant rhesus monkeys. J Pediatr Gastroenterol Nutr (2002) 1.01

Early diet impacts infant rhesus gut microbiome, immunity, and metabolism. J Proteome Res (2013) 1.01

Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats. J Nutr (2005) 1.01

The prevalence of low serum zinc and copper levels and dietary habits associated with serum zinc and copper in 12- to 36-month-old children from low-income families at risk for iron deficiency. J Am Diet Assoc (2007) 1.01

Effect of high dietary manganese intake of neonatal rats on tissue mineral accumulation, striatal dopamine levels, and neurodevelopmental status. Neurotoxicology (2002) 1.01

Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides. Am J Clin Nutr (2002) 1.01

Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. J Nutr (2002) 1.00

Maternal zinc deficiency reduces NMDA receptor expression in neonatal rat brain, which persists into early adulthood. J Neurochem (2005) 0.99

Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization. Am J Physiol Regul Integr Comp Physiol (2006) 0.99

Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 mo of age. Am J Clin Nutr (2003) 0.99

Global microRNA characterization reveals that miR-103 is involved in IGF-1 stimulated mouse intestinal cell proliferation. PLoS One (2010) 0.98

Alpha(1)-antitrypsin and antichymotrypsin in human milk: origin, concentrations, and stability. Am J Clin Nutr (2002) 0.97

Prevalence of anemia and micronutrient deficiencies in early pregnancy in rural Bangladesh, the MINIMat trial. Acta Obstet Gynecol Scand (2010) 0.97

Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods. Am J Clin Nutr (2002) 0.97

Iron supplementation during infancy--effects on expression of iron transporters, iron absorption, and iron utilization in rat pups. Am J Clin Nutr (2003) 0.97

Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life. Biochem Cell Biol (2006) 0.96

Anemia, iron deficiency, and iron deficiency anemia in 12-36-mo-old children from low-income families. Am J Clin Nutr (2005) 0.96

Metabolomic phenotyping validates the infant rhesus monkey as a model of human infant metabolism. J Pediatr Gastroenterol Nutr (2013) 0.96

Growth factor TGF-β induces intestinal epithelial cell (IEC-6) differentiation: miR-146b as a regulatory component in the negative feedback loop. Genes Nutr (2012) 0.96

Bioavailability of iron, zinc, and provitamin A carotenoids in biofortified staple crops. Nutr Rev (2014) 0.96

Effects of neonatal dietary manganese exposure on brain dopamine levels and neurocognitive functions. Neurotoxicology (2002) 0.95

Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants. J Pediatr Gastroenterol Nutr (2006) 0.95

Effect of iron treatment on nickel absorption and gene expression of the divalent metal transporter (DMT1) by human intestinal Caco-2 cells. Pharmacol Toxicol (2003) 0.95

A multiple-micronutrient-fortified beverage affects hemoglobin, iron, and vitamin A status and growth in adolescent girls in rural Bangladesh. J Nutr (2007) 0.93

Recent advances in knowledge of zinc nutrition and human health. Food Nutr Bull (2009) 0.93

Receptor-mediated uptake of ferritin-bound iron by human intestinal Caco-2 cells. J Nutr Biochem (2008) 0.92

Cellular internalization of lactoferrin in intestinal epithelial cells. Biometals (2004) 0.92

Effects of dietary factors on iron uptake from ferritin by Caco-2 cells. J Nutr Biochem (2007) 0.92

Molecular regulation of milk trace mineral homeostasis. Mol Aspects Med (2005) 0.91

Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model. Am J Physiol Gastrointest Liver Physiol (2004) 0.91

DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Am J Physiol Gastrointest Liver Physiol (2003) 0.91

Functional and molecular responses of suckling rat pups and human intestinal Caco-2 cells to copper treatment. J Nutr Biochem (2004) 0.91

Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse. Biometals (2004) 0.91

Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells. J Cell Physiol (2011) 0.91

Biochemical and molecular impacts of lactoferrin on small intestinal growth and development during early life. Biochem Cell Biol (2012) 0.90

Prevalence and predictors of iron deficiency in fully breastfed infants at 6 mo of age: comparison of data from 6 studies. Am J Clin Nutr (2009) 0.90

Zinc supplementation reduces iron absorption through age-dependent changes in small intestine iron transporter expression in suckling rat pups. J Nutr (2006) 0.89

Marginal maternal Zn intake in rats alters mammary gland Cu transporter levels and milk Cu concentration and affects neonatal Cu metabolism. J Nutr (2003) 0.89

The use of multiple logistic regression to identify risk factors associated with anemia and iron deficiency in a convenience sample of 12-36-mo-old children from low-income families. Am J Clin Nutr (2008) 0.89

Wilson's disease: changes in methionine metabolism and inflammation affect global DNA methylation in early liver disease. Hepatology (2013) 0.89

Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions. Brain Res (2008) 0.88

Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age. Acta Paediatr (2008) 0.88

Milk composition in free-ranging polar bears (Ursus maritimus) as a model for captive rearing milk formula. Zoo Biol (2011) 0.88

Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants. Am J Clin Nutr (2011) 0.87

Glycomacropeptide and alpha-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr (2003) 0.86

Hepcidin, the recently identified peptide that appears to regulate iron absorption. J Nutr (2004) 0.86

Iron deficiency, but not anemia, upregulates iron absorption in breast-fed peruvian infants. J Nutr (2006) 0.86

rRNA probes used to quantify the effects of glycomacropeptide and alpha-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli. J Pediatr Gastroenterol Nutr (2003) 0.86

Expression, characterization, and biologic activity of recombinant human lactoferrin in rice. J Pediatr Gastroenterol Nutr (2003) 0.86

Longitudinal changes in lactoferrin concentrations in human milk: a global systematic review. Crit Rev Food Sci Nutr (2014) 0.86

Characterization of mammalian receptors for lactoferrin. Biochem Cell Biol (2002) 0.85

Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. Am J Clin Nutr (2003) 0.85

Effects of alpha-lactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition. Am J Clin Nutr (2008) 0.85

Duration of exclusive breast-feeding and infant iron and zinc status in rural Bangladesh. J Nutr (2009) 0.84

Inhibitory effects of native and recombinant full-length camel lactoferrin and its N and C lobes on hepatitis C virus infection of Huh7.5 cells. J Med Microbiol (2011) 0.84

miR-214 regulates lactoferrin expression and pro-apoptotic function in mammary epithelial cells. J Nutr (2010) 0.84

Iron transporters in rat mammary gland: effects of different stages of lactation and maternal iron status. Am J Clin Nutr (2005) 0.84

Nutritional evaluation of protein hydrolysate formulas in healthy term infants: plasma amino acids, hematology, and trace elements. Am J Clin Nutr (2003) 0.83

Apo- and holo-lactoferrin stimulate proliferation of mouse crypt cells but through different cellular signaling pathways. Int J Biochem Cell Biol (2011) 0.83

Role of zinc in cellular zinc trafficking and mineralization in a murine osteoblast-like cell line. J Nutr Biochem (2010) 0.83

Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials. Am J Clin Nutr (2008) 0.83

Efficacy of an MFGM-enriched complementary food in diarrhea, anemia, and micronutrient status in infants. J Pediatr Gastroenterol Nutr (2011) 0.83

Interactions between nutrition and environmental exposures: effects on health outcomes in women and children. J Nutr (2007) 0.83

Should Partial Hydrolysates Be Used as Starter Infant Formula? A Working Group Consensus. J Pediatr Gastroenterol Nutr (2016) 0.83

Zinc supplementation does not affect growth, morbidity, or motor development of US term breastfed infants at 4-10 mo of age. Am J Clin Nutr (2006) 0.82

Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary gland. Am J Physiol Regul Integr Comp Physiol (2009) 0.82

Comparative Proteomics of Human and Macaque Milk Reveals Species-Specific Nutrition during Postnatal Development. J Proteome Res (2015) 0.82

Maternal multiple micronutrient supplementation has limited impact on micronutrient status of Bangladeshi infants compared with standard iron and folic acid supplementation. J Nutr (2010) 0.82

Maternal zinc deficiency in rats affects growth and glucose metabolism in the offspring by inducing insulin resistance postnatally. J Nutr (2010) 0.82