| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
|
Nature
|
2016
|
1.52
|
|
2
|
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase.
|
Chem Biol
|
2004
|
1.42
|
|
3
|
The mechanism-based inactivation of 2,3-dihydroxybiphenyl 1,2-dioxygenase by catecholic substrates.
|
J Biol Chem
|
2001
|
1.17
|
|
4
|
Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro.
|
J Med Chem
|
2004
|
1.01
|
|
5
|
Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic.
|
Proc Natl Acad Sci U S A
|
2008
|
0.99
|
|
6
|
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.
|
J Med Chem
|
2013
|
0.97
|
|
7
|
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
|
J Med Chem
|
2012
|
0.95
|
|
8
|
Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyl metabolites.
|
J Bacteriol
|
2007
|
0.94
|
|
9
|
beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae.
|
Biochemistry
|
2008
|
0.93
|
|
10
|
Structures of ternary complexes of BphK, a bacterial glutathione S-transferase that reductively dechlorinates polychlorinated biphenyl metabolites.
|
J Biol Chem
|
2006
|
0.89
|
|
11
|
Enzyme-dependent lysine deprotonation in EZH2 catalysis.
|
Biochemistry
|
2013
|
0.88
|
|
12
|
FenF: servicing the Mycosubtilin synthetase assembly line in trans.
|
Chembiochem
|
2007
|
0.86
|
|
13
|
Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.
|
J Med Chem
|
2013
|
0.82
|
|
14
|
Gatekeeping versus promiscuity in the early stages of the andrimid biosynthetic assembly line.
|
ACS Chem Biol
|
2008
|
0.82
|
|
15
|
Molecular basis for the substrate selectivity of bicyclic and monocyclic extradiol dioxygenases.
|
Biochem Biophys Res Commun
|
2005
|
0.76
|
|
16
|
Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.
|
Biochemistry
|
2016
|
0.75
|